DLST

Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial · P36957 · DLST on Sugi Atlas →

0 patent compounds predicted against DLST, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours

Clinical trials — most relevant to DLST by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
D-Cycloserine for Serine Palmitoyltransferase Inhibition PHASE4COMPLETED
1 or 6 Months of Dual Antiplatelet Therapy After Drug-coated Balloon Angioplasty for De-novo Small Coronary Artery Disease PHASE4NOT_YET_RECRUITING
Acid Lipase Replacement Investigating Safety and Efficacy (ARISE) in Participants With Lysosomal Acid Lipase Deficiency PHASE3COMPLETED
Venetoclax+HMA+Aclarubicin Versus Venetoclax+HMA in Treatment-Naive Elderly Patients With AML PHASE3UNKNOWN
A Study to Evaluate the Safety and Efficacy of Oral APL-1202 in Combination With Tislelizumab Compared to Tislelizumab Alone as Neoadjuvant Therapy in Patients With Muscle Invasive Bladder Cancer PHASE1/PHASE2UNKNOWN
Phase 1b Study of Pegylated Liposomal Doxorubicin and Pembrolizumab in Endocrine-resistant Breast Cancer PHASE1/PHASE2RECRUITING
A Prospective Clinical Study of BTK Inhibitor, PD-1 and Formustine in the First-line Treatment of Primary Central Nervous System Lymphoma PHASE1/PHASE2UNKNOWN
Vaccine Treatment for Advanced Non-Small Cell Lung Cancer PHASE1/PHASE2COMPLETED
Hereditary Sensory Neuropathy Serine Trial PHASE2UNKNOWN
Mutation-specific Therapy for the Long QT Syndrome PHASE2COMPLETED
LIGHT-PSMA-CART in Treating Patients With Castrate-Resistant Prostate Cancer PHASE1SUSPENDED
CD19-targeted CAR T Cells for Patients With Relapsed or Refractory in B-cell Acute Lymphoblastic Leukemia PHASE1UNKNOWN
A Phase I Clinical Study of HLX53 in Advanced/Metastatic Solid Tumors PHASE1UNKNOWN
Paclitaxel Cationic Liposome (Hepatic Arterial Infusion) in Combination With Systemic Therapy as First-Line Treatment in Colorectal Liver Metastases PHASE1RECRUITING
A Clinical Study to Evaluate the Safety and Efficacy of Anti-human CD 7 CAR-NK Cell Injection in Subjects With Relapsed and Refractory CD7-positive Hematological Malignancy EARLY_PHASE1NOT_YET_RECRUITING
Natural History Study of Pyruvate Dehydrogenase Deficiency nanUNKNOWN
Biomarker for Hurler Disease (BioHurler) nanWITHDRAWN
Natural History of the Leukodystrophies nanCOMPLETED
Influence of WNT4 VEZT FSHB and SIRT1 SNPs in Endometriosis: a Case Control Study of the Sardinian Population nanUNKNOWN
Study of Chediak-Higashi Syndrome nanRECRUITING
The Classification and Cause of Leukodystrophies of Unknown Cause nanCOMPLETED
The LD Lync Study - Natural History Study of Lipodystrophy Syndromes nanRECRUITING
Cellular Pharmacodynamics of Small Molecules in Lysosomal Storage Disorders nanUNKNOWN
Identification of a New Blood Biomarker for the Diagnosis and Prognosis of Liposarcomas nanRECRUITING
Natural History Study of SLC25A46 Mutation-related Mitochondriopathy nanCOMPLETED
Systemic Biomarkers of Brain Injury From Hyperammonemia nanRECRUITING
Evaluation of Botanicals for Mechanisms Related to Appetite and Fat Metabolism nanCOMPLETED
Nutritional Therapy of the Deficits of Oxidation Mitochondrial of the Fatty Acids nanCOMPLETED
Tolerability and Efficacy of L-Serine in Patients With GRIN-related Encephalopathy nanUNKNOWN
Fatty Acid Oxidation Defects and Insulin Sensitivity nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a DLST binder may also engage these)

ProteinNameSimilarity
Q9N0F1 1.000 Q9N0F1 →
P11179 1.000 P11179 →
Q9D2G2 1.000 Q9D2G2 →
Q9FLQ4 0.999 Q9FLQ4 →
Q01205 0.998 Q01205 →
Q8BKZ9 0.995 Q8BKZ9 →
Q8H107 0.994 Q8H107 →
P19262 0.992 P19262 →
P86197 0.992 P86197 →
Q90512 0.992 Q90512 →
P22439 0.991 P22439 →
P11180 0.991 P11180 →
PDHX Pyruvate dehydrogenase protein X component, mitochondrial 0.990 landscape →
O94681 0.990 O94681 →
P75392 0.989 P75392 →
DLAT Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial 0.988 landscape →
P08461 0.988 P08461 →
Q8BMF4 0.986 Q8BMF4 →
P53395 0.984 P53395 →
Q0WQF7 0.983 Q0WQF7 →
Q19749 0.982 Q19749 →
Q8GCY1 0.982 Q8GCY1 →
P0AFG7 0.981 P0AFG7 →
O59816 0.980 O59816 →
P65634 0.980 P65634 →
P9WIS6 0.980 P9WIS6 →
P35489 0.979 P35489 →
Q1RHI5 0.979 Q1RHI5 →
P9WIS7 0.979 P9WIS7 →
A2YQ56 0.979 A2YQ56 →