Sugi Predict

Sugi Predict / Targets / DUT

DUT

Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial · P33316 · DUT on Sugi Atlas →

17,712 patent compounds predicted against DUT, 6,379 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL1408618 SCHEMBL1408618 1.00 20/20
SCHEMBL1408681 SCHEMBL1408681 1.00 20/20
SCHEMBL1408708 SCHEMBL1408708 1.00 20/20
SCHEMBL1408710 SCHEMBL1408710 1.00 20/20
SCHEMBL1408766 SCHEMBL1408766 1.00 20/20
SCHEMBL1408769 SCHEMBL1408769 1.00 20/20
SCHEMBL1408818 SCHEMBL1408818 1.00 20/20
SCHEMBL1408821 SCHEMBL1408821 1.00 20/20
SCHEMBL1408836 SCHEMBL1408836 1.00 20/20
SCHEMBL1408839 SCHEMBL1408839 1.00 20/20
SCHEMBL1408858 SCHEMBL1408858 1.00 20/20
SCHEMBL1408861 SCHEMBL1408861 1.00 20/20
SCHEMBL1408883 SCHEMBL1408883 1.00 20/20
SCHEMBL1408885 SCHEMBL1408885 1.00 20/20
SCHEMBL1408918 SCHEMBL1408918 1.00 20/20
SCHEMBL1408920 SCHEMBL1408920 1.00 20/20
SCHEMBL1408963 SCHEMBL1408963 1.00 20/20
SCHEMBL1408964 SCHEMBL1408964 1.00 20/20
SCHEMBL1408975 SCHEMBL1408975 1.00 20/20
SCHEMBL1408991 SCHEMBL1408991 1.00 20/20

Clinical trials — most relevant to DUT by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
A RCT of TNF and ENT in the Treatment of Long-term Prognosis With Hepatitis B-related HCC After Curative Resection PHASE3UNKNOWN
Addition of Rituximab to Leflunomide in Patients With Active Rheumatoid Arthritis PHASE3COMPLETED
Therapeutic Equivalence of Fluorouracil Cream, 5% Compared With Fluorouracil 5% Topical Cream of MylanPharmaceuticals Inc., U.S.A in the Treatment of Actinic Keratosis PHASE3COMPLETED
A Multi-Histology Phase II Study of 5-Fluoro-2'-Deoxycytidine With Tetrahydrouridine (FdCyd + THU) PHASE2COMPLETED
A Trial of Gemcitabine, Infusional 5-Fluorouracil and Cisplatin for Advanced Pancreatic and Biliary Cancers PHASE2COMPLETED
Docetaxel Versus Docetaxel Plus Cisplatin Versus Docetaxel Plus S-1 as Second-line Chemotherapy in Metastatic Gastric Cancer PHASE2UNKNOWN
Prospective Phase II Randomized Trial of Postoperative Adjuvant Chemotherapy in Patients With High Risk Colon Cancer PHASE2UNKNOWN
Liver Resection and Floxuridine Plus Fluorouracil and Leucovorin in Treating Patients With Liver Metastases From Colorectal Cancer PHASE2COMPLETED
Clinical Study of EBV-LMP1 Targeted DNAzyme to Treat Nasopharyngeal Carcinoma PHASE1/PHASE2COMPLETED
Safety, Tolerance, Pharmacokinetic and Antiviral Study of Amdoxovir in Combination With Zidovudine in Adults With HIV PHASE1/PHASE2COMPLETED
Phase II Study of Ribose, Uridine, and Thymidine for a Complex Syndrome Involving Excessive 5'-Nucleotidase Activity PHASE2COMPLETED
Safety and Impact of Dasatinib on Viral Persistence and Inflammation in People With HIV Under Antiretroviral Treatment PHASE2COMPLETED
Metronomic Chemotherapy With Tegafur/Uracil for Head and Neck Squamous Cell Carcinoma PHASE2UNKNOWN
Deoxynucleosides Pyrimidines as Treatment for Mitochondrial Depletion Syndrome PHASE2RECRUITING
FdCyd and THU for Advanced Solid Tumors PHASE1COMPLETED
5-Fluoro-2'-Deoxcyctidine and Tetrahydrouridine to Treat Patients With Advanced Cancer PHASE1COMPLETED
ASTX727 in Recurrent/Progressive Non-enhancing IDH Mutant Gliomas PHASE1RECRUITING
Olaparib in Combination With Vorinostat in Patients With Relapsed/Refractory and/or Metastatic Breast Cancer PHASE1ACTIVE_NOT_RECRUITING
Study of Cytolytic Viral Activation Therapy (CVAT) for Recurrent/Metastatic Nasopharyngeal Carcinoma PHASE1UNKNOWN
Combination Chemotherapy in Treating Patients With Locally Advanced or Metastatic Solid Tumors PHASE1COMPLETED
Combination Chemotherapy in Treating Patients Who Have Advanced Solid Tumors PHASE1COMPLETED
PRO#0118: Decitabine Plus Mini Flu-Bu PHASE1COMPLETED
Decitabine Alone or in Combination With Venetoclax, Gilteritinib, Enasidenib, or Ivosidenib as Maintenance Therapy for the Treatment of Acute Myeloid Leukemia in Remission PHASE1RECRUITING
To Study the Oral Bioavailability of a New Combination Formation of Decitabine and Tetrahydrouridine in Healthy Males PHASE1COMPLETED
Nucleoside Therapy in Patients With Telomere Biology Disorders PHASE1RECRUITING
Observational Study Evaluating the Prevalence of Enzyme Deficiency in Pulmonology Clinics (ADA) nanUNKNOWN
Implementation and Quality Assurance of DPYD-genotyping in Patients Treated With Fluoropyrimidines. nanCOMPLETED
Prevalence of Adenosine Deaminase (ADA) Enzyme Deficiency Disease in Adult Patients With Pulmonary Alveolar Proteinosis nanUNKNOWN
Thymidylate Synthase Polymorphisms as a Predictor of Toxicity to 5-Fluorouracil Based Chemotherapy in Stage III Colon Cancer nanUNKNOWN
Clinical and Diagnostic Significance of Endothelial Dysfunction and Myocardial Contractility in Patients With AML nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a DUT binder may also engage these)

ProteinNameSimilarity
P70583 — 0.978 P70583 →
Q6UDM0 — 0.974 Q6UDM0 →
Q91YE2 — 0.972 Q91YE2 →
P28893 — 0.971 P28893 →
Q0DDI1 — 0.971 Q0DDI1 →
P10234 — 0.971 P10234 →
Q28969 — 0.971 Q28969 →
Q90030 — 0.971 Q90030 →
MACROD1 ADP-ribose glycohydrolase MACROD1 0.971 landscape →
Q6TDU1 — 0.971 Q6TDU1 →
Q0PKV7 — 0.970 Q0PKV7 →
Q580W5 — 0.970 Q580W5 →
A3KMV1 — 0.970 A3KMV1 →
P89469 — 0.970 P89469 →
Q8K3A9 — 0.970 Q8K3A9 →
EGLN2 Prolyl hydroxylase EGLN2 0.969 landscape →
PANK1 Pantothenate kinase 1 0.969 landscape →
O70161 — 0.969 O70161 →
Q6AJ39 — 0.969 Q6AJ39 →
Q9TUX8 — 0.969 Q9TUX8 →
Q9UPV7 — 0.969 Q9UPV7 →
O35071 — 0.968 O35071 →
O43435 — 0.968 O43435 →
Q0DCT8 — 0.968 Q0DCT8 →
B9EHT4 — 0.968 B9EHT4 →
O35787 — 0.968 O35787 →
MKNK1 MAP kinase-interacting serine/threonine-protein kinase 1 0.968 landscape →
Q99933 — 0.968 Q99933 →
Q3U2S4 — 0.968 Q3U2S4 →
Q8BTW9 — 0.968 Q8BTW9 →