DUT

Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial

17,712 patent compounds predicted against DUT, 6,379 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL1408618	1.00	20/20
SCHEMBL1408681	1.00	20/20
SCHEMBL1408708	1.00	20/20
SCHEMBL1408710	1.00	20/20
SCHEMBL1408766	1.00	20/20
SCHEMBL1408769	1.00	20/20
SCHEMBL1408818	1.00	20/20
SCHEMBL1408821	1.00	20/20
SCHEMBL1408836	1.00	20/20
SCHEMBL1408839	1.00	20/20
SCHEMBL1408858	1.00	20/20
SCHEMBL1408861	1.00	20/20
SCHEMBL1408883	1.00	20/20
SCHEMBL1408885	1.00	20/20
SCHEMBL1408918	1.00	20/20
SCHEMBL1408920	1.00	20/20
SCHEMBL1408963	1.00	20/20
SCHEMBL1408964	1.00	20/20
SCHEMBL1408975	1.00	20/20
SCHEMBL1408991	1.00	20/20

Germline variants in DUT on Sugi Variant → ClinVar classifications, population frequency, and predictor agreement (AlphaMissense, SaProt, REVEL) Full DUT gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

Clinical trials — most relevant to DUT by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
A RCT of TNF and ENT in the Treatment of Long-term Prognosis With Hepatitis B-related HCC After Curative Resection	PHASE3	UNKNOWN
Addition of Rituximab to Leflunomide in Patients With Active Rheumatoid Arthritis	PHASE3	COMPLETED
Therapeutic Equivalence of Fluorouracil Cream, 5% Compared With Fluorouracil 5% Topical Cream of MylanPharmaceuticals Inc., U.S.A in the Treatment of Actinic Keratosis	PHASE3	COMPLETED
A Multi-Histology Phase II Study of 5-Fluoro-2'-Deoxycytidine With Tetrahydrouridine (FdCyd + THU)	PHASE2	COMPLETED
A Trial of Gemcitabine, Infusional 5-Fluorouracil and Cisplatin for Advanced Pancreatic and Biliary Cancers	PHASE2	COMPLETED
Docetaxel Versus Docetaxel Plus Cisplatin Versus Docetaxel Plus S-1 as Second-line Chemotherapy in Metastatic Gastric Cancer	PHASE2	UNKNOWN
Prospective Phase II Randomized Trial of Postoperative Adjuvant Chemotherapy in Patients With High Risk Colon Cancer	PHASE2	UNKNOWN
Liver Resection and Floxuridine Plus Fluorouracil and Leucovorin in Treating Patients With Liver Metastases From Colorectal Cancer	PHASE2	COMPLETED
Clinical Study of EBV-LMP1 Targeted DNAzyme to Treat Nasopharyngeal Carcinoma	PHASE1/PHASE2	COMPLETED
Safety, Tolerance, Pharmacokinetic and Antiviral Study of Amdoxovir in Combination With Zidovudine in Adults With HIV	PHASE1/PHASE2	COMPLETED
Phase II Study of Ribose, Uridine, and Thymidine for a Complex Syndrome Involving Excessive 5'-Nucleotidase Activity	PHASE2	COMPLETED
Safety and Impact of Dasatinib on Viral Persistence and Inflammation in People With HIV Under Antiretroviral Treatment	PHASE2	COMPLETED
Metronomic Chemotherapy With Tegafur/Uracil for Head and Neck Squamous Cell Carcinoma	PHASE2	UNKNOWN
Deoxynucleosides Pyrimidines as Treatment for Mitochondrial Depletion Syndrome	PHASE2	RECRUITING
FdCyd and THU for Advanced Solid Tumors	PHASE1	COMPLETED
5-Fluoro-2'-Deoxcyctidine and Tetrahydrouridine to Treat Patients With Advanced Cancer	PHASE1	COMPLETED
ASTX727 in Recurrent/Progressive Non-enhancing IDH Mutant Gliomas	PHASE1	RECRUITING
Olaparib in Combination With Vorinostat in Patients With Relapsed/Refractory and/or Metastatic Breast Cancer	PHASE1	ACTIVE_NOT_RECRUITING
Study of Cytolytic Viral Activation Therapy (CVAT) for Recurrent/Metastatic Nasopharyngeal Carcinoma	PHASE1	UNKNOWN
Combination Chemotherapy in Treating Patients With Locally Advanced or Metastatic Solid Tumors	PHASE1	COMPLETED
Combination Chemotherapy in Treating Patients Who Have Advanced Solid Tumors	PHASE1	COMPLETED
PRO#0118: Decitabine Plus Mini Flu-Bu	PHASE1	COMPLETED
Decitabine Alone or in Combination With Venetoclax, Gilteritinib, Enasidenib, or Ivosidenib as Maintenance Therapy for the Treatment of Acute Myeloid Leukemia in Remission	PHASE1	RECRUITING
To Study the Oral Bioavailability of a New Combination Formation of Decitabine and Tetrahydrouridine in Healthy Males	PHASE1	COMPLETED
Nucleoside Therapy in Patients With Telomere Biology Disorders	PHASE1	RECRUITING
Observational Study Evaluating the Prevalence of Enzyme Deficiency in Pulmonology Clinics (ADA)	nan	UNKNOWN
Implementation and Quality Assurance of DPYD-genotyping in Patients Treated With Fluoropyrimidines.	nan	COMPLETED
Prevalence of Adenosine Deaminase (ADA) Enzyme Deficiency Disease in Adult Patients With Pulmonary Alveolar Proteinosis	nan	UNKNOWN
Thymidylate Synthase Polymorphisms as a Predictor of Toxicity to 5-Fluorouracil Based Chemotherapy in Stage III Colon Cancer	nan	UNKNOWN
Clinical and Diagnostic Significance of Endothelial Dysfunction and Myocardial Contractility in Patients With AML	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a DUT binder may also engage these)

Protein	Name	Similarity
P70583	—	0.978	P70583 →
Q6UDM0	—	0.974	Q6UDM0 →
Q91YE2	—	0.972	Q91YE2 →
P28893	—	0.971	P28893 →
Q0DDI1	—	0.971	Q0DDI1 →
P10234	—	0.971	P10234 →
Q28969	—	0.971	Q28969 →
Q90030	—	0.971	Q90030 →
MACROD1	ADP-ribose glycohydrolase MACROD1	0.971	landscape →
Q6TDU1	—	0.971	Q6TDU1 →
Q580W5	—	0.970	Q580W5 →
Q0PKV7	—	0.970	Q0PKV7 →
P89469	—	0.970	P89469 →
A3KMV1	—	0.970	A3KMV1 →
Q8K3A9	—	0.970	Q8K3A9 →
EGLN2	Prolyl hydroxylase EGLN2	0.969	landscape →
PANK1	Pantothenate kinase 1	0.969	landscape →
O70161	—	0.969	O70161 →
Q6AJ39	—	0.969	Q6AJ39 →
Q9TUX8	—	0.969	Q9TUX8 →
Q9UPV7	—	0.969	Q9UPV7 →
O35071	—	0.968	O35071 →
O43435	—	0.968	O43435 →
Q0DCT8	—	0.968	Q0DCT8 →
O35787	—	0.968	O35787 →
MKNK1	MAP kinase-interacting serine/threonine-protein kinase 1	0.968	landscape →
B9EHT4	—	0.968	B9EHT4 →
Q99933	—	0.968	Q99933 →
Q8BTW9	—	0.968	Q8BTW9 →
Q3U2S4	—	0.968	Q3U2S4 →