EPHA8 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Dasatinib Anhydrous (SCHEMBL8226)	1.00	2/20
Dasatinib Anhydrous (SCHEMBL290515)	1.00	2/20
Masitinib (SCHEMBL717239)	1.00	2/20
Masitinib (SCHEMBL1096348)	0.94	2/20
SCHEMBL717173	0.88	2/20
SCHEMBL717184	0.87	2/20
SCHEMBL715882	0.85	2/20
SCHEMBL715899	0.85	2/20
SCHEMBL715940	0.85	2/20
SCHEMBL716706	0.83	2/20
SCHEMBL719085	0.83	2/20
SCHEMBL1146489	0.81	2/20
SCHEMBL718560	0.81	2/20
SCHEMBL1146496	0.81	2/20
SCHEMBL715811	0.80	2/20
SCHEMBL716627	0.80	2/20
SCHEMBL717080	0.80	2/20
SCHEMBL1147074	0.80	2/20
SCHEMBL715741	0.80	2/20
SCHEMBL715885	0.80	2/20

Clinical trials — most relevant to EPHA8 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Investigating the Potential Role of Aerosolized Retinoic Acid, a Potent Vitamin A Metabolite for Treating COVID-19 Anosmia and Retinoic Acid Insufficiency .A Novel Approach for Regaining Sense of Smell.	PHASE4	UNKNOWN
Safety and Efficacy of the PAINLESS Nerve Growth Factor CHF6467 in Optic Pathway Glioma (OPG)	PHASE2	ACTIVE_NOT_RECRUITING
Postoperative EGFR-TKI Therapy forContralateral Pulmonary Nodules in Patients With EGFR-Mutant NSCLC（ARMOR2501）	PHASE2	RECRUITING
Ruxolitinib in Combination With Trastuzumab in Metastatic HER2 Positive Breast Cancer	PHASE1/PHASE2	COMPLETED
Phase II Study of Vandetanib in Individuals With Kidney Cancer	PHASE2	COMPLETED
PiCCA Study (Panitumumab in Combination With Cisplatin/Gemcitabine)	PHASE2	COMPLETED
S0713: Oxaliplatin, Capecitabine, Cetuximab, and RT Followed By Surgery in Pts W/Stage II or III Rectal Cancer	PHASE2	COMPLETED
ASLAN001 in Patients With Advanced or Metastatic Cholangiocarcinoma Who Progressed on at Least 1 Line of Systemic Therapy	PHASE2	COMPLETED
A Series of Pilot Studies to Evaluate the haemoDynamic and mEtabolic Effects oF apelIn aNd rElaxin	PHASE2	UNKNOWN
Study of Anlotinib Plus Chemoradiotherapy in Patients With Locally Advanced NSCLC	PHASE1/PHASE2	UNKNOWN
A Safety, Tolerability and PK Study of DCC-2618 in Patients With Advanced Malignancies	PHASE1	COMPLETED
Study of TARCEVA (Erlotinib) as Adjuvant Treatment for Locally Advanced Head and Neck Squamous Cell Carcinoma	PHASE1	COMPLETED
Changes in Skin Innervation of Neurologically Asymptomatic Type 2 Diabetic Patients: the Correlation With the Diabetic Parameters and Neurotrophins.	nan	UNKNOWN
Pathological and Nuclear Medicine Factors for Prognosis in Lung Carcinoma	nan	COMPLETED
The Role of Gene Changes in Brain Tumor Formation and Growth	nan	COMPLETED
A Retrospective Study to Determine the Incidence of NTRK Fusions. NTRK Study	nan	COMPLETED
Expression of CD19 Complex in Lymphoproliferative Disorders	nan	UNKNOWN
K-RAS Oncogene Mutation in Patients With Advanced Non-Small Cell Lung Cancer Associated With Exposure to Wood Smoke and Tobacco Smoking: Therapeutic Implications	nan	COMPLETED
Clinical Significance of DKK2 Protein in Cerebral Ischemia-reperfusion Injury	nan	UNKNOWN
Spinal Cord Stimulation for Spinal Cord Injury Patients - Regain Walk and Alleviate Pain	nan	RECRUITING
C-X-C Chemokine Receptor 4 in Chronic Lymphocytic Leukemia	nan	UNKNOWN
Toxins Removal and Inflammatory State modulAtion During Online Hemodiafiltration: Comparison of Two Different Dialyzers	nan	UNKNOWN
Prospective Monocentric Clinical-biological Database	nan	RECRUITING
Biomarker Research in Inherited Movement Disorders	nan	RECRUITING
Investigating Phenotypic, Epigenetic, and NeuroGenetic Traits in Rare and Ultra-rare Neurodevelopmental Disorders (Project PENGUIN)	nan	RECRUITING
Epidural Electrical Stimulation for Spinal Cord Injury Patients and Corticospinal Motor Circuit Improvement	nan	RECRUITING
Genetic Study of Newly Diagnosed Central Nervous System Tumors in Young Children	nan	COMPLETED
Investigation of Methylation of EGFR in the Response of the Cetuximab in Metastatic Colorectal Cancer Patients	nan	COMPLETED
The Association Between Executive Functions and Candidate Genes of Dopaminergic and Noradrenergic Systems in Attention Deficit Hyperactivity Disorder (ADHD)	nan	COMPLETED
The Roles of Neutrophil Elastase in Lung Cancer	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a EPHA8 binder may also engage these)

Protein	Name	Similarity
O09127	—	1.000	O09127 →
EPHB4	Ephrin type-B receptor 4	0.998	landscape →
P54754	—	0.995	P54754 →
EPHB3	Ephrin type-B receptor 3	0.994	landscape →
Q03145	—	0.992	Q03145 →
P54761	—	0.992	P54761 →
EPHA2	Ephrin type-A receptor 2	0.991	landscape →
Q60629	—	0.991	Q60629 →
O73878	—	0.991	O73878 →
EPHA5	Ephrin type-A receptor 5	0.991	landscape →
Q91735	—	0.990	Q91735 →
Q8BYG9	—	0.990	Q8BYG9 →
P54757	—	0.990	P54757 →
Q1KL86	—	0.990	Q1KL86 →
P54755	—	0.989	P54755 →
P0C0K6	—	0.988	P0C0K6 →
O73875	—	0.988	O73875 →
O42422	—	0.988	O42422 →
Q07497	—	0.988	Q07497 →
Q90344	—	0.988	Q90344 →
Q07498	—	0.987	Q07498 →
P0C0K7	—	0.987	P0C0K7 →
O13146	—	0.986	O13146 →
Q06805	—	0.986	Q06805 →
Q63474	—	0.986	Q63474 →
Q03146	—	0.986	Q03146 →
P55203	—	0.985	P55203 →
EPHA6	Ephrin type-A receptor 6	0.985	landscape →
Q8CBF3	—	0.985	Q8CBF3 →
P51840	—	0.985	P51840 →