FH

Fumarate hydratase, mitochondrial · P07954 · FH on Sugi Atlas →

0 patent compounds predicted against FH, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours

Clinical trials — most relevant to FH by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Phenoxybenzamine Versus Doxazosin in PCC Patients PHASE4COMPLETED
Sintilimab in FH-deficient Renal Cell Carcinoma PHASE2UNKNOWN
Single Agent Regorafenib in First-line for Metastatic/Unresectable KIT/PDGFR Wild Type GIST PHASE2COMPLETED
A Study of Bezafibrate in Mitochondrial Myopathy PHASE2COMPLETED
Chronic Fatigue Syndrome: A Presumptive Mitochondrial Disorder PHASE2WITHDRAWN
Analysis of the Modulation of Serum Hepcidin Level in Response to Iron Oral Intake: Potential Interest for the Differential Diagnosis Between Ferroportin Disease and Dysmetabolic Hepatosiderosis. PHASE2COMPLETED
A Phase II Study of Bevacizumab and Erlotinib in Subjects With Advanced Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC) or Sporadic Papillary Renal Cell Cancer PHASE2COMPLETED
Natural History Study of Mitochondrial Myopathy nanRECRUITING
SLSMDS Natural History Study nanUNKNOWN
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC) nanRECRUITING
Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine nanCOMPLETED
Tissue Sample Study for Mitochondrial Disorders nanENROLLING_BY_INVITATION
GDF-15 as a Biomarker for Mitochondrial Disease nanCOMPLETED
Natural History Study of FDXR Mutation-related Mitochondriopathy nanCOMPLETED
The Natural History of Mitochondrial Diseases nanRECRUITING
Mitoferrin-1 Expression in Erythropoietic Protoporphyria (Porphyria Rare Disease Clinical Research Consortium (RDCRC)) nanCOMPLETED
Identification of Large-Scale Mutations of POLG Gene by QMPSF in Patients With Mitochondrial DNA Instability. nanUNKNOWN
Nicotinamide Riboside and Mitochondrial Biogenesis nanCOMPLETED
Fatty Acid Oxidation Defects and Insulin Sensitivity nanCOMPLETED
Mitochondrial Dysfunction in Phelan-McDermid Syndrome nanCOMPLETED
Assessing the Role of Mitochondrial Dysfunction in Primary Progressive Multiple Sclerosis nanUNKNOWN
The Genetics of Diabetes in Southern California Chinese Americans nanWITHDRAWN
Development of a Predictive Model for the Risk of Metastatic Disease in PPGLs, a Retrospective Cohort Study nanNOT_YET_RECRUITING
Transgenerational Metabolic-Immune Biomarkers of Neurological and Neurodevelopmental Disorders nanRECRUITING
Identification of New Candidate Genes in Patients With Mitochondrial Disease by High Resolution Chromosome Analysis on DNA Chip nanCOMPLETED
Relationship Between Mitochondrial Dysfunction and Fatique in Cancer Patients Following External Beam Radiation Therapy nanCOMPLETED
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes nanNOT_YET_RECRUITING
ACTIV- Exercise Intervention in Healthy Young Men nanCOMPLETED
Gastrointestinal Dysfunction in Children Affected With Mitochondrial Disorders nanCOMPLETED
Rhizomelic Chondrodysplasia Punctata Registry nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a FH binder may also engage these)

ProteinNameSimilarity
Q60HF9 1.000 Q60HF9 →
P10173 1.000 P10173 →
Q7SX99 1.000 Q7SX99 →
P97807 1.000 P97807 →
P55250 1.000 P55250 →
O17214 1.000 O17214 →
Q9CMK1 1.000 Q9CMK1 →
Q9RR70 1.000 Q9RR70 →
Q92PB6 1.000 Q92PB6 →
O94552 1.000 O94552 →
P08417 0.999 P08417 →
Q8Z6R6 0.998 Q8Z6R6 →
Q89XM2 0.998 Q89XM2 →
Q9FI53 0.997 Q9FI53 →
Q9KCX4 0.997 Q9KCX4 →
P14408 0.997 P14408 →
Q9A6I5 0.997 Q9A6I5 →
Q8UEY7 0.997 Q8UEY7 →
P05042 0.996 P05042 →
P07343 0.996 P07343 →
Q7WG65 0.996 Q7WG65 →
Q83ML8 0.996 Q83ML8 →
Q8X769 0.996 Q8X769 →
P28894 0.996 P28894 →
Q9JTR0 0.996 Q9JTR0 →
Q54VA2 0.996 Q54VA2 →
Q7W0A2 0.995 Q7W0A2 →
Q8KTE1 0.995 Q8KTE1 →
Q7W4N9 0.995 Q7W4N9 →
Q81SA0 0.995 Q81SA0 →