FTH1

Ferritin heavy chain · P02794 · FTH1 on Sugi Atlas →

108 patent compounds predicted against FTH1, 96 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
(-)-Caryophyllene Oxide (SCHEMBL127077)	1.00	1/20
(-)-Caryophyllene Oxide (SCHEMBL676309)	1.00	1/20
(-)-Caryophyllene Oxide (SCHEMBL1532444)	1.00	1/20
(-)-Caryophyllene Oxide (SCHEMBL14763730)	1.00	1/20
(-)-Caryophyllene Oxide (SCHEMBL16489852)	1.00	1/20
(-)-Caryophyllene Oxide (SCHEMBL16769854)	1.00	1/20
(-)-Caryophyllene Oxide (SCHEMBL17857878)	1.00	1/20
(-)-Caryophyllene Oxide (SCHEMBL18788522)	1.00	1/20
(-)-Caryophyllene Oxide (SCHEMBL21349931)	1.00	1/20
(-)-Caryophyllene Oxide (SCHEMBL24110084)	1.00	1/20
(-)-Caryophyllene Oxide (SCHEMBL24110118)	1.00	1/20
(-)-Caryophyllene Oxide (SCHEMBL26189380)	1.00	1/20
SCHEMBL23665800	0.83	1/20
Kobusone (SCHEMBL19361159)	0.68	1/20
(-)-Caryophyllene Oxide (SCHEMBL4254769)	0.65	1/20
SCHEMBL19420471	0.59	1/20
SCHEMBL19420473	0.59	1/20
SCHEMBL16181033	0.59	1/20
SCHEMBL24176164	0.56	1/20
SCHEMBL24176168	0.56	1/20

Clinical trials — most relevant to FTH1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Bovine Lactoferrin to Prevent and Cure Iron Deficiency and Iron Deficiency Anemia in Complicated Pregnancies	PHASE4	COMPLETED
A Trial of Iron Replacement in Patients With Iron Deficiency.	PHASE4	COMPLETED
Ferric Carboximaltose on Intra-myocardial Iron Load in Patients With Heart Failure	PHASE4	UNKNOWN
Intravenous Iron for Treatment of Anaemia Before Cardiac Surgery	PHASE4	COMPLETED
to Assess the Effect of Early vs Routine Iron Supplementation on Iron Store and Growth in Term Infants	PHASE4	UNKNOWN
Does Heme Oxygenase-1 Induction Ameliorate Cardiac Injury After Myocardial Infarction?	PHASE1/PHASE2	COMPLETED
Analysis of the Modulation of Serum Hepcidin Level in Response to Iron Oral Intake: Potential Interest for the Differential Diagnosis Between Ferroportin Disease and Dysmetabolic Hepatosiderosis.	PHASE2	COMPLETED
Open Trail of γIFN for Friedreich Ataxia	PHASE2	COMPLETED
Role of USP35 in the Detection of Ferroptosis in Juvenile Autoimmune Hepatitis	nan	NOT_YET_RECRUITING
Candidate Gene for Hyperferritinemia	nan	UNKNOWN
Daily vs Intermittent Iron Therapy in Pregnancy	nan	COMPLETED
Evaluation of Clinical Characteristics and Outcome of COVID19 Pneumonia in Assiut University Hospital	nan	UNKNOWN
Out Come Study To Define Laboratory Parameters That Are Best Suited to Diagnose Functional Iron Deficiency	nan	COMPLETED
Hemochromatosis and Iron Overload Screening Study (HEIRS)	nan	COMPLETED
Is Helicobacter Pylori Infection a Cause or Treatment Failure of Iron Deficiency Anemia in Children in Bangladesh?	nan	COMPLETED
Incidence of Iron Deficiency in Polycythemia Vera (PV) and Association With Disease Features	nan	UNKNOWN
Effectiveness of a Biosimilar Epoetin Alfa in Stable 'End Stage Renal Failure'	nan	UNKNOWN
Cardiac Function in Patients With Hereditary Hemochromatosis	nan	COMPLETED
The Correlation Between Anemia of Chronic Diseases, Hepcidin and Vitamin D in IBD Patients	nan	UNKNOWN
Quantification of Liver Iron Overload and Steatosis Using Magnetic Resonance Imaging	nan	COMPLETED
Erythrocyte Apheresis Versus Phlebotomy in Hemochromatosis	nan	UNKNOWN
HEPFER-Evaluation of a New Phenotypic Biological Marker in Genetic Type 1 Hemochromatosis	nan	COMPLETED
Hepcidine and Iron Deficiency in Critically Ill Patients	nan	COMPLETED
Genes-in-Action - Hepcidin Regulation of Iron Supplementation	nan	COMPLETED
Maternal Serum Ferritin and Low Neonatal Birth Weight	nan	UNKNOWN
Assessment of Iron Deposition in Major Organs of Hemodialysis Patients	nan	UNKNOWN
Inflamation, Gut Leakage, Iron Status After 6000m Ergometer Test in Elite Rowers.	nan	COMPLETED
GDF 15 in Sickle Cell Disease and Hereditary Spherocytosis	nan	UNKNOWN
Iron Deficincy Among Children With type1 DM in Assiut University Hospital	nan	NOT_YET_RECRUITING
Prohepcidin, Inflammation and Iron Homeostasis in Hemodialysis Patients With Chronic Hepatitis C	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a FTH1 binder may also engage these)

Protein	Name	Similarity
Q5R8J7	—	1.000	Q5R8J7 →
Q2MHN2	—	1.000	Q2MHN2 →
Q95MP7	—	1.000	Q95MP7 →
P29389	—	1.000	P29389 →
Q7SXA6	—	1.000	Q7SXA6 →
P19132	—	1.000	P19132 →
Q8MIP0	—	0.999	Q8MIP0 →
O46414	—	0.999	O46414 →
Q9XT73	—	0.999	Q9XT73 →
P80145	—	0.999	P80145 →
P49946	—	0.998	P49946 →
P49948	—	0.997	P49948 →
P07229	—	0.997	P07229 →
P25915	—	0.996	P25915 →
P09528	—	0.996	P09528 →
P85836	—	0.995	P85836 →
P17663	—	0.994	P17663 →
P08267	—	0.994	P08267 →
P19130	—	0.993	P19130 →
P85835	—	0.992	P85835 →
P85838	—	0.992	P85838 →
P18685	—	0.992	P18685 →
P49947	—	0.991	P49947 →
P85837	—	0.991	P85837 →
P07798	—	0.991	P07798 →
P42577	—	0.991	P42577 →
P85839	—	0.990	P85839 →
P07797	—	0.982	P07797 →
Q5R538	—	0.979	Q5R538 →
P02792	—	0.976	P02792 →