GAS6 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL3048653	0.51	17/20
SCHEMBL1885183	0.51	17/20
SCHEMBL486036	0.51	17/20
SCHEMBL559524	0.57	16/20
SCHEMBL2260565	0.57	16/20
SCHEMBL559186	0.50	16/20
SCHEMBL2256601	0.50	16/20
SCHEMBL559177	0.52	15/20
SCHEMBL2258657	0.52	15/20
SCHEMBL559165	0.48	14/20
SCHEMBL558556	0.45	14/20
SCHEMBL2256894	0.45	14/20
SCHEMBL559371	0.44	14/20
SCHEMBL2256609	0.44	14/20
SCHEMBL558202	0.53	13/20
SCHEMBL2259421	0.53	13/20
SCHEMBL3450061	0.52	13/20
SCHEMBL3450065	0.52	13/20
SCHEMBL559344	0.48	13/20
SCHEMBL559345	0.48	13/20

Clinical trials — most relevant to GAS6 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Treatment With HMG-COA Reductase Inhibitor of Growth and Bone Abnormalities in Children With Noonan Syndrome	PHASE3	COMPLETED
Lapatinib Ditosylate in Treating Patients With Unresectable Liver or Biliary Tract Cancer	PHASE2	COMPLETED
Study Evaluating Toxicity & Efficacy of Lenalidomide(Revlimid®)in Chemotherapy-Naïve AIPC Patients	PHASE2	COMPLETED
Clinical Study of EBV-LMP1 Targeted DNAzyme to Treat Nasopharyngeal Carcinoma	PHASE1/PHASE2	COMPLETED
Anastrozole or Fulvestrant in Treating Postmenopausal Patients With Breast Cancer	PHASE2	COMPLETED
PhII 5-Azacytidine Plus Valproic Acid and Eventually Atra in Intermediate II and High Risk MDS	PHASE2	COMPLETED
Akt Inhibitor MK2206 in Treating Patients With Recurrent or Advanced Endometrial Cancer	PHASE2	COMPLETED
A Phase 2 Study of Farnesyl Transferase Inhibitor (R115777, Tipifarnib) in Patients With Refractory or Relapsed Acute Myeloid Leukemia.	PHASE2	COMPLETED
A Clinical Trial of TAA06 Injection in Advanced Solid Tumors	PHASE1	UNKNOWN
Liquid Biopsy and Pancreas Cancer: Detection of AXL(+) CTCs (CTC-AXL-PANC)	nan	RECRUITING
Characterization of Microbiological and Genetic Features in Prostate Cancer and Their Association with Disease Stage	nan	ENROLLING_BY_INVITATION
Whole Genome Scan of Extended Families With Familial Vocal Cord Paralysis	nan	COMPLETED
The Ameliorative Effect of C-Kit (+) Hepatic Endothelial Cells With Mertk Deficiency on Nonalcoholic Steatohepatitis	nan	ACTIVE_NOT_RECRUITING
Genetic Determinants of Sudden Cardiac Death	nan	COMPLETED
Pathological and Nuclear Medicine Factors for Prognosis in Lung Carcinoma	nan	COMPLETED
Biomarkers in Patients With Advanced Rhabdomyosarcoma	nan	COMPLETED
Vascular Endothelial Factor Gene Polymorphism in Preeclampsia	nan	COMPLETED
ADRB3, ROCK2 and GEF Levels in Overactive Bladder Patients	nan	COMPLETED
Inherited Genetic Susceptibility in Langerhans Cell Histiocytosis (LCH)	nan	ACTIVE_NOT_RECRUITING
Biomarkers And Neurological Outcome in Neonates (BANON)	nan	COMPLETED
Autophagy Bladder Cancer	nan	UNKNOWN
Molecular Analysis of Thoracic Malignancies	nan	ENROLLING_BY_INVITATION
Rational Therapeutics Based on Matched Tumor and Normal Tissue	nan	COMPLETED
Identifying Methylation Biomarkers for Monitoring Bladder Tumors	nan	UNKNOWN
The Predictive Value of Guangzhou Panel for Recurrence in Early-stage Colorectal Cancer	nan	NOT_YET_RECRUITING
Identification of Genetic Variants Associated With Unexpected Infant Death Syndrome	nan	RECRUITING
Biomarker Panel in Ovarian Torsion	nan	UNKNOWN
Molecular Basis of the Growth Axis in Short Stature	nan	COMPLETED
Germline Alterations of Tumor Susceptibility Genes in New York Cancer Patients	nan	ACTIVE_NOT_RECRUITING
Genetic Study in Patients With Stage II or Stage III Colon Cancer	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a GAS6 binder may also engage these)

Protein	Name	Similarity
Q61592	—	1.000	Q61592 →
Q63772	—	1.000	Q63772 →
Q0VCN6	—	0.984	Q0VCN6 →
Q9C0A0	—	0.983	Q9C0A0 →
P15306	—	0.982	P15306 →
Q53RD9	—	0.981	Q53RD9 →
Q8R4K8	—	0.980	Q8R4K8 →
A6NFU0	—	0.980	A6NFU0 →
Q6ZRI0	—	0.980	Q6ZRI0 →
A1A5Y0	—	0.979	A1A5Y0 →
Q501P1	—	0.979	Q501P1 →
Q9H4D0	—	0.978	Q9H4D0 →
Q8R553	—	0.978	Q8R553 →
P07204	—	0.978	P07204 →
Q71U07	—	0.978	Q71U07 →
A7E3C4	—	0.978	A7E3C4 →
Q0V8T0	—	0.977	Q0V8T0 →
DLK1	Protein delta homolog 1	0.977	landscape →
Q9NPY3	—	0.977	Q9NPY3 →
Q8K099	—	0.977	Q8K099 →
Q99JH7	—	0.977	Q99JH7 →
Q28146	—	0.977	Q28146 →
Q63374	—	0.977	Q63374 →
Q9WUA1	—	0.977	Q9WUA1 →
Q9JLC4	—	0.977	Q9JLC4 →
Q0VCG9	—	0.977	Q0VCG9 →
Q0V8S9	—	0.977	Q0V8S9 →
Q8VDA1	—	0.977	Q8VDA1 →
Q14114	—	0.977	Q14114 →
Q9W7R4	—	0.976	Q9W7R4 →