GFM1

Elongation factor G, mitochondrial · Q96RP9 · GFM1 on Sugi Atlas →

0 patent compounds predicted against GFM1, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours

Clinical trials — most relevant to GFM1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Clinical Evaluation of the Effect of Metformin in Sepsis PHASE3UNKNOWN
A Study of the Efficacy and Safety of MT1621 in Thymidine Kinase 2 (TK2) Deficiency (Treatment naïve) PHASE3WITHDRAWN
A Study of Bezafibrate in Mitochondrial Myopathy PHASE2COMPLETED
Biologic Correlative Taxotere/AC PHASE2COMPLETED
Deoxynucleosides Pyrimidines as Treatment for Mitochondrial Depletion Syndrome PHASE2RECRUITING
Safety and Efficacy of Etravirine in Friedreich Ataxia Patients PHASE2COMPLETED
ONC201 in Recurrent/Refractory Metastatic Breast Cancer and Advanced Endometrial Carcinoma PHASE2COMPLETED
Dynamics of Muscle Mitochondria in Type 2 Diabetes (DYNAMMO T2D) EARLY_PHASE1COMPLETED
Effectiveness of Light for Enhancement of Cognition by Transcranial Repeated Application (ELECTRA) EARLY_PHASE1COMPLETED
Skeletal Muscle Regeneration in Survivors of Critical Illness: How to Prevent Satellite Cell Failure? nanRECRUITING
Dynamics of Muscle Mitochondria in Type 2 Diabetes Exercise nanCOMPLETED
Nicotinamide Riboside and Mitochondrial Biogenesis nanCOMPLETED
Pathogenic Insights and Search for Biomarkers in RFC1-ataxia/CANVAS nanRECRUITING
Drug Repurposing for Mitochondrial Disorders Using iPSCs Derived Neural Cells nanRECRUITING
Exercise-mediated Rescue of Mitochondrial Dysfunctions Driving Insulin Resistance nanCOMPLETED
Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy Men nanRECRUITING
Effect of Branched Chain Amino Acids on Muscle nanCOMPLETED
Pilot Trial of Sirolimus/MEC in High Risk Acute Myelogenous Leukemia (AML) nanCOMPLETED
Mitochondrial Dysfunctions Driving Insulin Resistance nanCOMPLETED
Tissue Sample Study for Mitochondrial Disorders nanENROLLING_BY_INVITATION
Mitochondrial Dysfunction in Diabetes nanCOMPLETED
Measuring Protein Turnover in Humans Across the Lifespan by Metabolic Labeling With Deuterium Oxide nanRECRUITING
Nutraceutical Composition Containing Natural Products Derivatives on the Modulation of the Endocrine Neuroimmune Axis nanCOMPLETED
Relationship Between Mitochondrial Dysfunction and Fatique in Cancer Patients Following External Beam Radiation Therapy nanCOMPLETED
GDF-15 as a Biomarker for Mitochondrial Disease nanCOMPLETED
Clinical Study of Hydroxytyrosol (HT) in Mitochondrial Diseases nanCOMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes nanCOMPLETED
Mitochondrial Activity and Myosteatosis in the Cachexia of Cancers of the Upper Aerodigestive Tract nanUNKNOWN
Gastrointestinal Dysfunction in Children Affected With Mitochondrial Disorders nanCOMPLETED
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes nanNOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a GFM1 binder may also engage these)

ProteinNameSimilarity
Q5R9V1 1.000 Q5R9V1 →
Q07803 1.000 Q07803 →
Q8K0D5 1.000 Q8K0D5 →
Q9XV52 1.000 Q9XV52 →
B5VN01 1.000 B5VN01 →
A7A0X4 1.000 A7A0X4 →
P25039 1.000 P25039 →
B0WGM1 1.000 B0WGM1 →
A5PKR8 1.000 A5PKR8 →
B6K286 1.000 B6K286 →
A6RLH0 1.000 A6RLH0 →
Q7Q1K8 1.000 Q7Q1K8 →
A1CXG4 1.000 A1CXG4 →
Q72VM5 1.000 Q72VM5 →
A7EVV9 1.000 A7EVV9 →
A7RR04 1.000 A7RR04 →
B2WBM8 1.000 B2WBM8 →
Q7SH14 1.000 Q7SH14 →
Q9VM33 1.000 Q9VM33 →
Q04VH3 1.000 Q04VH3 →
Q08BB1 1.000 Q08BB1 →
B4JQM7 1.000 B4JQM7 →
B4MZW9 1.000 B4MZW9 →
B8N9M2 1.000 B8N9M2 →
Q8F983 1.000 Q8F983 →
Q9USZ1 1.000 Q9USZ1 →
B4NZM7 1.000 B4NZM7 →
Q75CZ5 1.000 Q75CZ5 →
B4Q5D5 1.000 B4Q5D5 →
Q29N77 1.000 Q29N77 →