GFPT1

Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 · Q06210 · GFPT1 on Sugi Atlas →

811 patent compounds predicted against GFPT1, 426 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL5809762	1.00	1/20
SCHEMBL29490149	1.00	1/20
Trifluoroacetic Acid (SCHEMBL5763517)	0.95	1/20
SCHEMBL6106939	0.86	1/20
Trifluoroacetic Acid (SCHEMBL6106759)	0.81	1/20
SCHEMBL6109152	0.81	1/20
SCHEMBL6109830	0.77	1/20
SCHEMBL6108765	0.77	1/20
Hydrochloric Acid (SCHEMBL6110105)	0.76	1/20
Trifluoroacetic Acid (SCHEMBL6108973)	0.73	1/20
SCHEMBL6107805	0.72	1/20
SCHEMBL30762293	0.71	1/20
SCHEMBL6108977	0.70	1/20
Trifluoroacetic Acid (SCHEMBL5768365)	0.70	1/20
Trifluoroacetic Acid (SCHEMBL6108469)	0.70	1/20
SCHEMBL5744819	0.69	1/20
SCHEMBL6111691	0.69	1/20
SCHEMBL5745996	0.69	1/20
SCHEMBL5745274	0.68	1/20
Trifluoroacetic Acid (SCHEMBL6109077)	0.68	1/20

Clinical trials — most relevant to GFPT1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
SGLT-2 Inhibitor Empagliflozin Effects on Appetite and Weight Regulation.	PHASE4	COMPLETED
Bovine Lactoferrin to Prevent and Cure Iron Deficiency and Iron Deficiency Anemia in Complicated Pregnancies	PHASE4	COMPLETED
Reformulated F75 Milk to Treat Severe Acute Malnutrition	PHASE2/PHASE3	COMPLETED
Glutamate for Metabolic Intervention in Coronary Surgery	PHASE3	COMPLETED
Vaccine Treatment for Advanced Non-Small Cell Lung Cancer	PHASE1/PHASE2	COMPLETED
A Single-arm Trial of Roxadustat Combined With Retinoic Acid in the Treatment of Refractory Low-risk MDS	PHASE1/PHASE2	NOT_YET_RECRUITING
First-in-Human Evaluation of an Astrocytic Glutamate Transporter (EAAT2) PET Tracer in Dementia	PHASE1/PHASE2	RECRUITING
Metronomic Chemotherapy With Tegafur/Uracil for Head and Neck Squamous Cell Carcinoma	PHASE2	UNKNOWN
Dynamic PET/CT Evaluated the Response of Neoadjuvant Anti-PD1 Combination With Chemotherapy for Ⅱa-Ⅲb NSCLC	PHASE2	UNKNOWN
Neurobiology of a Mutation in Glycine Metabolism in Psychotic Disorders	PHASE2	COMPLETED
PK and PD of YG1699 in CKD Patients With Diabetes	PHASE1	NOT_YET_RECRUITING
Glutamine and Traumatic Brain Injury	EARLY_PHASE1	UNKNOWN
Evaluation of Blood Protein O-GlcNAcylation Levels in Children	nan	RECRUITING
Evaluation of Blood and Cardiac Protein O-GlcNAcylation Levels in Cardiac Surgery in Children	nan	RECRUITING
A Study of the Interaction Between Tumor Susceptibility Gene Glycine N-methyltransferase (GNMT) and Lung Cancer	nan	UNKNOWN
Oral Glutamine in Cardiopulmonary Bypass	nan	COMPLETED
Utility of PET-MRI in Surveillance of Paediatric Brain Tumours	nan	RECRUITING
Dried Fruit and Postprandial Glycemia Trial	nan	UNKNOWN
Markers of Liver Apoptosis After Anesthesia With Sevoflurane or Propofol	nan	COMPLETED
18F-fluorodeoxyglucose (18F-FDG) Positron Emission Tomography in Oncology	nan	COMPLETED
Clinical Utility of Breath Tests in GI	nan	COMPLETED
The Role of Sugars in Fat Accumulation in the Liver	nan	RECRUITING
Dual PETOvac - Dual Time PET/CT in the Preoperative Assessment of Ovarian Cancer	nan	UNKNOWN
A Prospective Study on the Diagnosis of Malignant Tumors With 18F-FGIn PET/CT	nan	RECRUITING
Erythrocyte Transport of Lactate During Exercise (TELE Project)	nan	RECRUITING
Sodium Glucose Co-Transporter 2 Inhibitors on Estimated Glomerular Filtration Rate in Diabetic Versus Non-Diabetic Chronic Kidney Disease Patients	nan	COMPLETED
Intraumbilical Amino Acids and Glucose Supplementation Via Port by Severe IUGR in Human Fetuses	nan	COMPLETED
Acute Glycine Pharmacodynamic Study	nan	COMPLETED
Early Versus Late FDG-PET/CT in Bladder Cancer	nan	COMPLETED
Glutamate Supplementation in Young Men	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a GFPT1 binder may also engage these)

Protein	Name	Similarity
Q4KMC4	—	1.000	Q4KMC4 →
P47856	—	1.000	P47856 →
P82808	—	1.000	P82808 →
O94808	—	0.998	O94808 →
P53704	—	0.998	P53704 →
Q9Z2Z9	—	0.997	Q9Z2Z9 →
Q8SRI2	—	0.996	Q8SRI2 →
P14742	—	0.996	P14742 →
Q08DQ2	—	0.996	Q08DQ2 →
Q09740	—	0.993	Q09740 →
Q9LIP9	—	0.990	Q9LIP9 →
Q663R1	—	0.985	Q663R1 →
Q5QZH5	—	0.985	Q5QZH5 →
E0U070	—	0.985	E0U070 →
Q577Y1	—	0.984	Q577Y1 →
Q8DTY0	—	0.984	Q8DTY0 →
Q5L3P0	—	0.984	Q5L3P0 →
P41390	—	0.984	P41390 →
Q8Z2Q2	—	0.983	Q8Z2Q2 →
P0CI73	—	0.983	P0CI73 →
Q8VYB2	—	0.983	Q8VYB2 →
Q5RAZ4	—	0.983	Q5RAZ4 →
P00927	—	0.983	P00927 →
Q7ZXP9	—	0.983	Q7ZXP9 →
Q87SR3	—	0.983	Q87SR3 →
Q9KG45	—	0.983	Q9KG45 →
Q5XHA8	—	0.982	Q5XHA8 →
Q7W334	—	0.982	Q7W334 →
Q6FZH6	—	0.982	Q6FZH6 →
Q5WLG7	—	0.982	Q5WLG7 →