GHRHR

Growth hormone-releasing hormone receptor · Q02643 · GHRHR on Sugi Atlas →

3,271 patent compounds predicted against GHRHR, 2,784 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Docetaxel Anhydrous (SCHEMBL121908)	1.00	1/20
Docetaxel Anhydrous (SCHEMBL121909)	1.00	1/20
Docetaxel Anhydrous (SCHEMBL189598)	1.00	1/20
Docetaxel Anhydrous (SCHEMBL189599)	1.00	1/20
Docetaxel Anhydrous (SCHEMBL301509)	1.00	1/20
Docetaxel Anhydrous (SCHEMBL301510)	1.00	1/20
Docetaxel Anhydrous (SCHEMBL4417)	0.99	1/20
Docetaxel Anhydrous (SCHEMBL4418)	0.99	1/20
Docetaxel Anhydrous (SCHEMBL4419)	0.99	1/20
Docetaxel Anhydrous (SCHEMBL177909)	0.99	1/20
Docetaxel Anhydrous (SCHEMBL758082)	0.99	1/20
Docetaxel Anhydrous (SCHEMBL903452)	0.99	1/20
Docetaxel Anhydrous (SCHEMBL4303992)	0.99	1/20
Docetaxel Anhydrous (SCHEMBL5553029)	0.99	1/20
Docetaxel Anhydrous (SCHEMBL7109515)	0.99	1/20
Docetaxel Anhydrous (SCHEMBL7109517)	0.99	1/20
Docetaxel Anhydrous (SCHEMBL8547497)	0.99	1/20
Docetaxel Anhydrous (SCHEMBL10105760)	0.99	1/20
Docetaxel Anhydrous (SCHEMBL12127059)	0.99	1/20
Docetaxel Anhydrous (SCHEMBL12127062)	0.99	1/20

Clinical trials — most relevant to GHRHR by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Growth Hormone and Glucose Metabolism	PHASE4	COMPLETED
Safety and Efficacy of SR-hGH (Sustained-release Human Growth Hormone, Declage Inj.)	PHASE4	COMPLETED
Antibiotic Treatment Trial for Small Intestinal Bacterial Overgrowth	PHASE4	UNKNOWN
Investigating the Potential Role of Aerosolized Retinoic Acid, a Potent Vitamin A Metabolite for Treating COVID-19 Anosmia and Retinoic Acid Insufficiency .A Novel Approach for Regaining Sense of Smell.	PHASE4	UNKNOWN
Cool.Click™ Adolescent Transition Study: Study of Saizen® in Subjects With Childhood-onset Growth Hormone Deficiency	PHASE3	COMPLETED
Replacement GH Therapy After Bariatric Surgery in Patients With Very Severe Obesity	PHASE3	COMPLETED
Growth Hormone in the Treatment of HIV-Associated Wasting	PHASE3	COMPLETED
Efficacy and Safety of an Oral Growth Hormone Drug in the Treatment of Fibromyalgia	PHASE2	COMPLETED
Growth Hormone Treatment in Children With Phelan McDermid Syndrome	PHASE2	COMPLETED
A Pharmacodynamic Study of Leuprorelin Gelatin-Free Formulation in Female Subjects With Uterine Fibroids.	PHASE2	COMPLETED
Ghrelin for Alcohol Use in Non-Treatment-Seeking Heavy Drinkers	PHASE2	COMPLETED
The Effect of GHRH Therapy on Myocardial Structure and Function in Congestive Heart Failure	PHASE2	COMPLETED
Recombinant Human Growth Hormone During Rehabilitation From Traumatic Brain Injury.	PHASE2	COMPLETED
Growth Hormone Replacement in Veterans With GWI and AGHD (GWIT)	PHASE2	RECRUITING
Effectiveness of Growth Hormone Releasing Hormone in Reducing Abdominal Fat in People Who Are Obese	PHASE2	COMPLETED
Extension Study of IONIS-GHR-LRx Administered to Participants With Acromegaly Being Treated With Long-acting Somatostatin Receptor Ligands	PHASE2	COMPLETED
An Open-label, Multi-center, Expanded Treatment Protocol of Pasireotide LAR in Patients With Acromegaly	nan	APPROVED_FOR_MARKETING
Sexually Dimorphic Effects of GHRH in Adult Growth Hormone Testing	nan	COMPLETED
Consequence of Lifetime Isolated Growth Hormone Deficiency	nan	COMPLETED
Study of the Effect of Growth Hormone-Releasing Hormone Antagonist on Growth Hormone Release in Acromegaly	nan	COMPLETED
Effects of an Amino Acid-Based hGH Secretagogue on Triiodythyronine	nan	COMPLETED
Pharmacokinetics of Ghrelin	nan	COMPLETED
Acylated Ghrelin Response to Acute Exercise in Obesity	nan	COMPLETED
The Effects of Growth Hormone Treatment Discontinuation in Adults on Metabolic Profile, Body Composition and Quality Of Life (GAMBOL Study)	nan	UNKNOWN
Ghrelin and Gastric Emptying in Children With Functional Dyspepsia	nan	COMPLETED
Growth Hormone Feedback to Insulin-like Growth Factor-I (IGF-1) and Oral Glucose Tolerance Test (OGTT)	nan	COMPLETED
Peri-operative Dynamics of the Growth Hormone Axis in Subjects With Acromegaly	nan	COMPLETED
Effects of Short-term Growth Hormone in HIV-infected Patients	nan	COMPLETED
Growth and Metabolic Response to GH and GnRHa Treatment Versus GH Alone in Boys Born SGA.	nan	COMPLETED
Growth Hormone Administration and Its Effects on Cardiovascular Risk Factors in Growth Hormone Deficient Women	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a GHRHR binder may also engage these)

Protein	Name	Similarity
P34999	—	1.000	P34999 →
O35659	—	0.998	O35659 →
GCGR	Glucagon receptor	0.997	landscape →
Q28992	—	0.997	Q28992 →
P32082	—	0.996	P32082 →
Q61606	—	0.996	Q61606 →
Q5FWI2	—	0.995	Q5FWI2 →
VIPR2	Vasoactive intestinal polypeptide receptor 2	0.995	landscape →
Q0P543	—	0.995	Q0P543 →
GLP1R	Glucagon-like peptide 1 receptor	0.994	landscape →
O46502	—	0.994	O46502 →
P41588	—	0.994	P41588 →
P43219	—	0.994	P43219 →
P43218	—	0.994	P43218 →
Q02644	—	0.994	Q02644 →
P32301	—	0.993	P32301 →
P23811	—	0.993	P23811 →
P30083	—	0.993	P30083 →
VIPR1	Vasoactive intestinal polypeptide receptor 1	0.993	landscape →
GIPR	Gastric inhibitory polypeptide receptor	0.992	landscape →
A0A2Z2U4G9	—	0.991	A0A2Z2U4G9 →
P97751	—	0.990	P97751 →
P35000	—	0.990	P35000 →
P30082	—	0.989	P30082 →
SCTR	Secretin receptor	0.987	landscape →
Q9IB86	—	0.986	Q9IB86 →
Q5IXF8	—	0.985	Q5IXF8 →
P25117	—	0.984	P25117 →
P49190	—	0.984	P49190 →
CALCR	Calcitonin receptor	0.983	landscape →