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GTPBP4

GTP-binding protein 4 · Q9BZE4 · GTPBP4 on Sugi Atlas →

482 patent compounds predicted against GTPBP4, 306 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Asp-3026 Asp-3026 (SCHEMBL2827739) 1.00 1/20
Asp-3026 Asp-3026 (SCHEMBL29354559) 1.00 1/20
Asp-3026 Asp-3026 (SCHEMBL30090555) 1.00 1/20
Asp-3026 Asp-3026 (SCHEMBL31142530) 1.00 1/20
SCHEMBL14866379 SCHEMBL14866379 0.94 1/20
SCHEMBL14866342 SCHEMBL14866342 0.91 1/20
SCHEMBL14866398 SCHEMBL14866398 0.90 1/20
SCHEMBL14866485 SCHEMBL14866485 0.89 1/20
SCHEMBL2823904 SCHEMBL2823904 0.88 1/20
SCHEMBL14866411 SCHEMBL14866411 0.88 1/20
SCHEMBL14866656 SCHEMBL14866656 0.88 1/20
SCHEMBL14866222 SCHEMBL14866222 0.87 1/20
SCHEMBL14866446 SCHEMBL14866446 0.87 1/20
SCHEMBL21478092 SCHEMBL21478092 0.87 1/20
SCHEMBL2824222 SCHEMBL2824222 0.87 1/20
SCHEMBL14866149 SCHEMBL14866149 0.87 1/20
SCHEMBL2820888 SCHEMBL2820888 0.86 1/20
SCHEMBL22493266 SCHEMBL22493266 0.85 1/20
SCHEMBL11979353 SCHEMBL11979353 0.85 1/20
SCHEMBL14866618 SCHEMBL14866618 0.85 1/20

Clinical trials — most relevant to GTPBP4 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Simvastatin + Cetuximab/Irinotecan in K-ras Mutant Colorectal Cancer (CRC) PHASE2COMPLETED
Safety and Efficacy of AAV9/AP4B1 (BFB-101) For Patients With AP4B1-related Hereditary Spastic Paraplegia Type 47 (SPG47) PHASE1/PHASE2NOT_YET_RECRUITING
Melpida: Recombinant Adeno-associated Virus (serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt) PHASE1/PHASE2RECRUITING
NEO100 and High-Grade Meningioma PHASE2RECRUITING
R115777 to Treat Children With Neurofibromatosis Type 1 and Progressive Plexiform Neurofibromas PHASE2COMPLETED
Study of the Pathophysiological Mechanisms Involved in Bleeding Events nanCOMPLETED
Gait in Rare Diseases nanCOMPLETED
Muscle Tissue Bank for Muscular Dystrophy nanCOMPLETED
Role of Polymorphisms in the IL-1 Gene Cluster nanCOMPLETED
Gene Analysis of Parkinson's Disease nanCOMPLETED
Exploring the Genetics of Neuropathic Pain nanRECRUITING
Natural History Evaluation of Charcot Marie Tooth Disease (CMT) Types CMT1B, CMT2A, CMT4A, CMT4C, and Others nanRECRUITING
ADRB3, ROCK2 and GEF Levels in Overactive Bladder Patients nanCOMPLETED
New Genes Involved in Molecular Etiology of Rett Syndrome Through DNA Microarray Comparative Genomic Hybridization nanCOMPLETED
Investigating the Genetic Basis of Pseudoexfoliation Syndrome, Angle-closure Glaucoma and Primary Open-angle Glaucoma nanRECRUITING
Genetic Characterization of Parkinson's Disease nanCOMPLETED
Clinical and Laboratory Analysis of Familial Cancer nanCOMPLETED
Exome Analysis in Hearing Impaired Patients nanUNKNOWN
Characterization of Microbiological and Genetic Features in Prostate Cancer and Their Association with Disease Stage nanENROLLING_BY_INVITATION
Autophagy in Systemic Lupus Erythematosus nanUNKNOWN
Prevalence of a Non-Expressing 11B Mutation in Aka Peoples of the Central African Republic nanCOMPLETED
Genetic Analysis of Gray Platelet Syndrome nanCOMPLETED
Signs and Symptoms of Genetic Abnormalities Linked to Inherited Heart Disease nanCOMPLETED
Characterization of New Candidate Genes in Cases of Human Inherited Thrombocytopenia (CATCH) nanCOMPLETED
Family Blood Pressure Program - GenNet Network nanCOMPLETED
Genetic Analysis of Parkinson's Disease nanCOMPLETED
Relationship Between Genes Important in Blood Pressure Regulation and Blood Pressure Therapy in Hypertension nanCOMPLETED
Classification, Functional Stratification and Biomarkers in Ciliopathy (CILLICORIRCM) nanCOMPLETED
Exome Sequencing for Atypical Femoral Fractures nanCOMPLETED
Mapping Novel Disease Genes for Dilated Cardiomyopathy nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a GTPBP4 binder may also engage these)

ProteinNameSimilarity
Q99ME9 — 1.000 Q99ME9 →
Q99P77 — 1.000 Q99P77 →
Q9V411 — 1.000 Q9V411 →
Q74ZK6 — 1.000 Q74ZK6 →
Q6FRV0 — 0.999 Q6FRV0 →
Q02892 — 0.999 Q02892 →
O94659 — 0.998 O94659 →
Q6CM00 — 0.997 Q6CM00 →
O44411 — 0.997 O44411 →
G0S8F1 — 0.997 G0S8F1 →
Q54N72 — 0.996 Q54N72 →
Q9U6A9 — 0.994 Q9U6A9 →
Q9C6I8 — 0.992 Q9C6I8 →
Q9NZN3 — 0.987 Q9NZN3 →
Q9QXY6 — 0.986 Q9QXY6 →
Q9WVK4 — 0.986 Q9WVK4 →
Q5E9R3 — 0.986 Q5E9R3 →
Q8SVJ8 — 0.985 Q8SVJ8 →
B4HMY3 — 0.985 B4HMY3 →
P53914 — 0.985 P53914 →
Q28Z41 — 0.985 Q28Z41 →
Q94CF0 — 0.984 Q94CF0 →
B4LNA1 — 0.984 B4LNA1 →
Q21086 — 0.984 Q21086 →
Q8R491 — 0.984 Q8R491 →
B3NML0 — 0.983 B3NML0 →
B4KN00 — 0.983 B4KN00 →
Q99LH1 — 0.983 Q99LH1 →
NAT10 RNA cytidine acetyltransferase 0.983 landscape →
B3MIF1 — 0.983 B3MIF1 →