HADHA

Trifunctional enzyme subunit alpha, mitochondrial · P40939 · HADHA on Sugi Atlas →

0 patent compounds predicted against HADHA, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours

Clinical trials — most relevant to HADHA by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
TAKE TIME Pioglitazone Reverses Defects in Mitochondrial Biogenesis in Patients With T2DM PHASE4COMPLETED
Clinical Evaluation of the Effect of Metformin in Sepsis PHASE3UNKNOWN
Overcoming Primary Resistance to Immunotherapy in Metastatic Melanoma PHASE2COMPLETED
Acetylcarnitine and Insulin Sensitivity PHASE2COMPLETED
Thyroid Hormone for Treatment of Nonalcoholic Steatohepatitis in Veterans PHASE2RECRUITING
Metabolic Cofactor Supplementation in Alzheimer's Disease (AD) and Parkinson's Disease (PD) Patients PHASE2COMPLETED
The Effects of Coenzyme A Combined With Abiraterone on Patients With CRPC PHASE1/PHASE2UNKNOWN
A Study of Bezafibrate in Mitochondrial Myopathy PHASE2COMPLETED
Atorvastatin, L-Carnitine and Non-Alcoholic Steatohepatitis PHASE2UNKNOWN
Fatty Acid Oxidation Defects and Insulin Sensitivity nanCOMPLETED
Compassionate Use of Triheptanoin (C7) for Inherited Disorders of Energy Metabolism nanNO_LONGER_AVAILABLE
Triheptanoin (UX007) to Treat Citrate Transporter Deficiency nanNO_LONGER_AVAILABLE
In and ex Vivo Mitochondrial Function of the Heart nanCOMPLETED
Nicotinamide Riboside and Mitochondrial Biogenesis nanCOMPLETED
Mitoquines in COPD nanUNKNOWN
Mitochondrial Methylation in Type 2 Diabetes nanCOMPLETED
Systemic Biomarkers of Brain Injury From Hyperammonemia nanRECRUITING
The RolE oF Androgen Excess in MUscle Energy MetaboLism in Women With PolyCystic Ovary Syndrome (REFUEL PCOS) Study 2 nanUNKNOWN
Tissue Sample Study for Mitochondrial Disorders nanENROLLING_BY_INVITATION
Mitochondrial Dysfunction in Diabetes nanCOMPLETED
Mitochondrial Assessment in Critical Ill Patients in Intensive Care nanNOT_YET_RECRUITING
REFUEL PCOS Study 1 nanUNKNOWN
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes nanCOMPLETED
Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine nanCOMPLETED
GDF-15 as a Biomarker for Mitochondrial Disease nanCOMPLETED
Lifestyle Intervention in Preparation for Pregnancy (LIPP) nanCOMPLETED
Effects of Parenteral L-carnitine Supplementation in Premature Neonates nanCOMPLETED
Study of Protein Translocation in Patients With Beta-Oxidation Disorders nanCOMPLETED
Nephroprotective Effects of Carnitine and (PDE5) Inhibitor Agent Against Contrast Media-induced Nephropathy (CMN) nanUNKNOWN
Glycine and Magnesium+Thiamine for the Treatment of Primary Ciliary Dyskinesia nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a HADHA binder may also engage these)

ProteinNameSimilarity
Q29554 1.000 Q29554 →
Q64428 1.000 Q64428 →
Q8BMS1 0.998 Q8BMS1 →
Q95028 0.973 Q95028 →
Q9WUM5 0.970 Q9WUM5 →
Q5EA88 0.970 Q5EA88 →
A5GFY8 0.970 A5GFY8 →
O04226 0.970 O04226 →
P20373 0.969 P20373 →
Q3ULJ0 0.969 Q3ULJ0 →
Q96480 0.969 Q96480 →
Q61753 0.969 Q61753 →
Q6P824 0.969 Q6P824 →
O57656 0.969 O57656 →
Q60HD7 0.969 Q60HD7 →
Q27556 0.968 Q27556 →
A2VDC2 0.968 A2VDC2 →
O65361 0.968 O65361 →
P32296 0.968 P32296 →
Q9LF33 0.968 Q9LF33 →
PHGDH D-3-phosphoglycerate dehydrogenase 0.967 landscape →
Q9YGL2 0.967 Q9YGL2 →
P08507 0.967 P08507 →
Q5EAD2 0.967 Q5EAD2 →
ACAD9 Complex I assembly factor ACAD9, mitochondrial 0.967 landscape →
O04015 0.967 O04015 →
Q27567 0.967 Q27567 →
Q5XIZ6 0.967 Q5XIZ6 →
Q9FZE1 0.967 Q9FZE1 →
P00341 0.966 P00341 →