HAMP — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL21846698	1.00	4/20
SCHEMBL21846815	1.00	4/20
SCHEMBL21846819	1.00	4/20
SCHEMBL21891932	1.00	4/20
SCHEMBL21891981	1.00	4/20
SCHEMBL21846789	0.88	4/20
SCHEMBL21891835	0.88	4/20
SCHEMBL30433663	0.88	4/20
SCHEMBL21808325	0.83	4/20
SCHEMBL21846736	0.83	4/20
SCHEMBL30433828	0.83	4/20
SCHEMBL21808525	0.82	4/20
SCHEMBL21846820	0.78	4/20
SCHEMBL21891905	0.78	4/20
SCHEMBL21892129	0.76	4/20
SCHEMBL21892120	0.73	4/20
SCHEMBL21846765	0.73	4/20
SCHEMBL21891978	0.73	4/20
SCHEMBL21808329	0.72	4/20
SCHEMBL21808358	0.72	4/20

Clinical trials — most relevant to HAMP by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Bovine Lactoferrin to Prevent and Cure Iron Deficiency and Iron Deficiency Anemia in Complicated Pregnancies	PHASE4	COMPLETED
Intravenous Iron for Treatment of Anaemia Before Cardiac Surgery	PHASE4	COMPLETED
Treatment of Iron Deficiency Anaemia in Inflammatory Bowel Disease With Ferrous Sulphate	PHASE4	COMPLETED
HepciFer Study: Hepcidin Overexpression After Hepatectomy : Does Iron Supplementation Make Sense ?	PHASE3	COMPLETED
Analysis of the Modulation of Serum Hepcidin Level in Response to Iron Oral Intake: Potential Interest for the Differential Diagnosis Between Ferroportin Disease and Dysmetabolic Hepatosiderosis.	PHASE2	COMPLETED
Effect of Curcumin on Iron Metabolism in Healthy Volunteer	PHASE2	COMPLETED
Treatment of Iron Overload With Deferasirox (Exjade) in Hereditary Hemochromatosis and Myelodysplastic Syndrome	PHASE2	WITHDRAWN
Effects of Vitamin D Replacement on Hormones Regulating Iron Metabolism in Individuals With Chronic Kidney Disease	EARLY_PHASE1	COMPLETED
Genes-in-Action - Hepcidin Regulation of Iron Supplementation	nan	COMPLETED
Using Stable Iron Isotopic Techniques and Serum Hepcidin Profiles to Optimize Iron Supplementation	nan	COMPLETED
The Immunomodulatory Effects of Phlebotomy	nan	UNKNOWN
Prohepcidin, Inflammation and Iron Homeostasis in Hemodialysis Patients With Chronic Hepatitis C	nan	COMPLETED
The Correlation Between Anemia of Chronic Diseases, Hepcidin and Vitamin D in IBD Patients	nan	UNKNOWN
Hepcidin and Anemia in Trauma	nan	COMPLETED
Hepcidin: a Prognostic Marker of Morbidity and Mortality in Severe Sepsis?	nan	COMPLETED
Plasma Hepcidin Response to Differently Dosed Iron Supplements	nan	COMPLETED
Study of Serum Hepcidin Rate Variations During Menstrual Cycle	nan	COMPLETED
Cohort of Patients With Rare Iron Overloads Excluding C282Y Homozygosity	nan	COMPLETED
HEPFER-Evaluation of a New Phenotypic Biological Marker in Genetic Type 1 Hemochromatosis	nan	COMPLETED
BMPR2 Mutations and Iron Metabolism in Pulmonary Arterial Hypertension	nan	COMPLETED
Incidence of Iron Deficiency in Polycythemia Vera (PV) and Association With Disease Features	nan	UNKNOWN
Inflammatory Anemia Associated Parameters in Septic Patients	nan	UNKNOWN
GDF 15 in Sickle Cell Disease and Hereditary Spherocytosis	nan	UNKNOWN
Effects of Intravenous Injection of Erythropoietin on Hepcidin Pharmacokinetics in Healthy Volunteers	nan	COMPLETED
In Hepatitis C Patients Treated With Interferon and Ribavirin, Does Hepcidin Contribute to Treatment Induced Anaemia	nan	COMPLETED
Ischemic Preconditioning - Perspectives of Use Vivio/in Vitro Studies	nan	ENROLLING_BY_INVITATION
The Optimization of Bioavailability From Iron Supplements: Study 1	nan	COMPLETED
Assessment of Iron Deposition in Major Organs of Hemodialysis Patients	nan	UNKNOWN
Different Oral Iron Dosing Regimens in Treatment of Iron Deficency Anemia in Patients With Chronic Kidney Disease	nan	NOT_YET_RECRUITING
Hepcidin After Intravenous Iron Treatment	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a HAMP binder may also engage these)

Protein	Name	Similarity
Q5NVR8	—	0.998	Q5NVR8 →
Q8MJ80	—	0.994	Q8MJ80 →
Q9EQ21	—	0.994	Q9EQ21 →
Q5U9D2	—	0.993	Q5U9D2 →
Q99MH3	—	0.991	Q99MH3 →
Q80T19	—	0.990	Q80T19 →
P11478	—	0.983	P11478 →
P01257	—	0.980	P01257 →
Q7T273	—	0.979	Q7T273 →
Q9WUG6	—	0.979	Q9WUG6 →
A0A2I6EDM5	—	0.979	A0A2I6EDM5 →
P40753	—	0.978	P40753 →
B3IWF7	—	0.978	B3IWF7 →
Q801Y3	—	0.978	Q801Y3 →
Q5G865	—	0.978	Q5G865 →
P12838	—	0.978	P12838 →
Q64365	—	0.978	Q64365 →
P61516	—	0.978	P61516 →
Q62949	—	0.977	Q62949 →
Q765I2	—	0.977	Q765I2 →
P09916	—	0.977	P09916 →
P0C8A8	—	0.976	P0C8A8 →
P59666	—	0.976	P59666 →
P24259	—	0.976	P24259 →
A0A2I6EDM8	—	0.976	A0A2I6EDM8 →
P01261	—	0.976	P01261 →
P59665	—	0.976	P59665 →
Q3L180	—	0.976	Q3L180 →
Q5G863	—	0.976	Q5G863 →
P28312	—	0.976	P28312 →