HELZ

Probable helicase with zinc finger domain · P42694 · HELZ on Sugi Atlas →

0 patent compounds predicted against HELZ, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours

Clinical trials — most relevant to HELZ by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Compared the Efficacy and Safety of CDOP Combined With Chidamide and CDOP in de Novo Peripheral T Cell Lymphoma Patients PHASE3UNKNOWN
Alrizomadlin (APG-115) in Subjects With BAP1 Cancer Syndrome and Early-Stage Mesothelioma PHASE2WITHDRAWN
Clinical Study of EBV-LMP1 Targeted DNAzyme to Treat Nasopharyngeal Carcinoma PHASE1/PHASE2COMPLETED
Efficacy and Safety Assessment of Oral LBH589 in Adult Patients With Advanced Soft TIssue Sarcoma After Pre-treatment Failure PHASE2COMPLETED
Safety and Dose Escalation Study of Zinc Supplementation in Critically Ill Children PHASE1/PHASE2COMPLETED
5-azacytidine Valproic Acid and ATRA in AML and High Risk MDS PHASE2COMPLETED
Trial of the Histone-Deacetylase Inhibitor ITF2357 Followed by Mechlorethamine in Relapsed/Refractory Hodgkin's Lymphoma PHASE1/PHASE2COMPLETED
Safety and Impact of Dasatinib on Viral Persistence and Inflammation in People With HIV Under Antiretroviral Treatment PHASE2COMPLETED
Study of the Beach Regimen on Relapsed/Refractory Acute Myeloid Leukemia (R/R AML) PHASE2ACTIVE_NOT_RECRUITING
Phase I Dose Finding and Proof-of-concept Study of Panobinostat With Standard Dose Cytarabine and Daunorubicin for Untreated Acute Myeloid Leukemia or Advanced Myelodysplastic Syndrome PHASE1COMPLETED
Evaluation of the Safety and the Tolerability of a Combination of Two HIV Inducers in Patients With Undetectable Viral Load PHASE1COMPLETED
The Study of Quadruple Therapy Quercetin, Zinc, Metformin, and EGCG as Adjuvant Therapy for Early, Metastatic Breast Cancer and Triple-negative Breast Cancer, a Novel Mechanism EARLY_PHASE1UNKNOWN
Detection of IKZF1 Deletion Mutation in Patients With Acute Lymphoblastic Leukemia and Its Impact in Therapy nanUNKNOWN
PHF19 Gene Expression and EZH2 Gene Deletion in Acute Myeloid Leukemia nanUNKNOWN
DICER1-related Pleuropulmonary Blastoma Cancer Predisposition Syndrome: A Natural History Study nanRECRUITING
Serum Levels of Some Trace Elements in Hepatocellular Carcinoma Patients nanUNKNOWN
International PPB/DICER1 Registry nanRECRUITING
Biochemical Role of Circulating microRNAs Expression as Diagnostic Markers for Non-Hodgkin's Lymphoma Patients nanRECRUITING
Autophagy in Systemic Lupus Erythematosus nanUNKNOWN
Registry and Natural History Study for Early Onset Hereditary Spastic Paraplegia nanRECRUITING
Gene Mutations and Rescue in Human Congenital Diaphragmatic Hernia nanUNKNOWN
Mitochondrial Activity and Myosteatosis in the Cachexia of Cancers of the Upper Aerodigestive Tract nanUNKNOWN
Clinical Manifestations and Biomarkers in Amyotrophic Lateral Sclerosis Type 4 and Other Inherited Neurological Disorders of RNA Processing nanRECRUITING
Genetic Analysis of Hereditary Disorders of Hearing and Balance nanCOMPLETED
Whole-genome Sequencing Study in Patients With Diminished Ovarian Reserve nanUNKNOWN
Evaluation of Serum Gasdermin D Level As a Potential Biomarker of Disease Activity in Vitiligo Patients nanUNKNOWN
MicroRNA-1 (miRNA-1) and MicroRNA-133a (miRNA-133a) Levels After Acute Exercise in Ultimate Frisbee Athletes nanUNKNOWN
Zinc and the Synthesis of Zinc Binding Proteins (Protocol B) nanCOMPLETED
MiRNA223 and HMGB1 as Apredictos for Drug Resistant Epilepsy nanUNKNOWN
CMOP Regimen and Chidamide in the Treatment of Newly Diagnosed Peripheral T-cell Lymphoma nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a HELZ binder may also engage these)

ProteinNameSimilarity
Q6DFV5 1.000 Q6DFV5 →
Q6NYU2 1.000 Q6NYU2 →
Q6TV19 0.982 Q6TV19 →
A0A8J1LLF7 0.981 A0A8J1LLF7 →
A0A974H8H3 0.980 A0A974H8H3 →
B3DLA6 0.978 B3DLA6 →
Q8R418 0.977 Q8R418 →
A0MQH0 0.976 A0MQH0 →
Q96JC1 0.975 Q96JC1 →
Q8IWV8 0.974 Q8IWV8 →
Q6TUI4 0.974 Q6TUI4 →
A5HK05 0.972 A5HK05 →
Q5RDU9 0.972 Q5RDU9 →
Q6DC64 0.972 Q6DC64 →
Q9DAX9 0.972 Q9DAX9 →
Q9UJG1 0.971 Q9UJG1 →
Q8NFZ0 0.971 Q8NFZ0 →
Q80YV4 0.971 Q80YV4 →
HIRA Protein HIRA 0.971 landscape →
Q5F480 0.971 Q5F480 →
Q28C34 0.971 Q28C34 →
Q91W86 0.971 Q91W86 →
Q9R1D7 0.971 Q9R1D7 →
Q5ZIA0 0.971 Q5ZIA0 →
Q61666 0.970 Q61666 →
Q6IE70 0.970 Q6IE70 →
A0JMZ3 0.970 A0JMZ3 →
Q5RAQ5 0.970 Q5RAQ5 →
Q4R8V9 0.970 Q4R8V9 →
Q8K2D3 0.970 Q8K2D3 →