HLA-DRB1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL21110164	0.57	1/20
SCHEMBL21110564	0.55	1/20
SCHEMBL19345771	0.55	1/20
SCHEMBL19345772	0.55	1/20
SCHEMBL19345839	0.55	1/20
SCHEMBL19345910	0.55	1/20
SCHEMBL21109500	0.55	1/20
SCHEMBL21110146	0.55	1/20
SCHEMBL21110340	0.55	1/20
SCHEMBL21109567	0.54	1/20
SCHEMBL25244713	0.54	1/20
SCHEMBL25286159	0.54	1/20
SCHEMBL21109665	0.54	1/20
SCHEMBL25765342	0.53	1/20
SCHEMBL16999950	0.53	1/20
SCHEMBL25343287	0.53	1/20
SCHEMBL25343290	0.53	1/20
SCHEMBL25343293	0.53	1/20
SCHEMBL16008030	0.53	1/20
SCHEMBL21109733	0.53	1/20

Clinical trials — most relevant to HLA-DRB1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Peripheral Blood Stem Cell Transplant vs Bone Marrow Transplant in Individuals With Hematologic Cancers (BMT CTN 0201)	PHASE3	COMPLETED
Intra Bone Marrow Injection Of Unrelated Cord Blood Cells	PHASE1/PHASE2	UNKNOWN
Ro Plus CHOEP as First Line Treatment Before HSCT in Young Patients With Nodal Peripheral T-cell Lymphomas	PHASE1/PHASE2	ACTIVE_NOT_RECRUITING
Safety and Efficacy of Allogeneic HPV-specific T Cells in Adults With Recurrent or Metastatic HPV16+ Cancers	PHASE1/PHASE2	ACTIVE_NOT_RECRUITING
Consolidation Therapy in Patients With Hematologic Malignancies	PHASE1/PHASE2	WITHDRAWN
Vaccine Therapy in Treating Patients With Stage III or Stage IV Melanoma	PHASE1/PHASE2	COMPLETED
Study of Palifermin (Kepivance) in Persons Undergoing Unrelated Donor Allogeneic Hematopoietic Cell Transplantation	PHASE1/PHASE2	COMPLETED
Phase I Study of CTL Anti-DP Infusion Post-hematopoietic Stem Cell Transplantation	PHASE1	RECRUITING
Safety Study of Gene Modified Donor T-Cells in Adults With Advanced Hematologic Malignancies	PHASE1	WITHDRAWN
Safety and Immunogenicity Trial of Multi-peptide Vaccination to Prevent COVID-19 Infection in Adults	PHASE1	COMPLETED
RBL001/RBL002 Phase I Clinical Trial	PHASE1	COMPLETED
Clinical Study for the Safety and Therapeutic Efficacy of the AI-QMMM Designed TamavaqTM Personalised Vaccine in Patients With Newly Diagnosed Glioma.	EARLY_PHASE1	RECRUITING
Individualizing Anti-TNF Therapy in Patients With Inflammatory Bowel Disease	nan	RECRUITING
High Resolution Donor Recipient HLA Matching Level in Unrelated HSCT	nan	COMPLETED
Fatigue in Multiple Sclerosis and Its Relationship to Inflammatory and Neurodegenerative Markers of the Disease	nan	ENROLLING_BY_INVITATION
Clinical Relevance of Typing HLA-DR7-DQ2	nan	COMPLETED
Comparison of the Severity of Coronary Atherosclerosis With Tissue Compliance in Patients Within First Degree Relatives	nan	UNKNOWN
Role of Human Leukocyte Antigen Matching in Liver Transplantation and Its Relation to Outcomes	nan	COMPLETED
Preemptive HLA Genotyping for the Safe Use of Infliximab-combination Therapy in Inflammatory Bowel Disease	nan	UNKNOWN
Protein Studies of the Epstein-Barr Virus in Ethnically Diverse Populations	nan	COMPLETED
HLA-DQ in Acute Kidney Transplantation Rejection	nan	COMPLETED
Association of HY-restricting HLA Class II Alleles, Sex of Firstborn Child, and Pregnancy Outcome in RPL Patients	nan	COMPLETED
HLA Demographics Study in Adults With Type 1 Diabetes	nan	RECRUITING
Adding DNA-test for Screening of HLA-DQ2 and DQ8 to Improve Early Diagnosis of Celiac Disease	nan	UNKNOWN
Newborn Screening for Genetic Susceptibility to Type 1 Diabetes and Celiac Disease and Prospective Follow-up Study	nan	ACTIVE_NOT_RECRUITING
In Vitro Study of the Biological and Immunological Activity of Imotopes® Candidates on Blood Cells of Patients With Stabilized NMO	nan	COMPLETED
Celiac Disease in Children	nan	COMPLETED
HLA Matching - Unrelated Umbilical Cord Blood Transplantation	nan	COMPLETED
The MURDOCK Study Community Registry and Biorepository Multiple Sclerosis Cohort	nan	COMPLETED
Personalized Prediction of Tolerance and Immunogenicity in Hemophilia	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a HLA-DRB1 binder may also engage these)

Protein	Name	Similarity
P79483	—	1.000	P79483 →
Q30154	—	1.000	Q30154 →
P13762	—	1.000	P13762 →
P18211	—	1.000	P18211 →
P14483	—	1.000	P14483 →
P04230	—	1.000	P04230 →
P18470	—	1.000	P18470 →
P06343	—	0.998	P06343 →
P18469	—	0.998	P18469 →
P06342	—	0.997	P06342 →
P01921	—	0.997	P01921 →
P29826	—	0.997	P29826 →
P05538	—	0.997	P05538 →
P20040	—	0.997	P20040 →
P18468	—	0.996	P18468 →
P06345	—	0.996	P06345 →
P01915	—	0.996	P01915 →
P06341	—	0.995	P06341 →
P04440	—	0.995	P04440 →
P04231	—	0.994	P04231 →
P15982	—	0.994	P15982 →
P15464	—	0.993	P15464 →
Q9TVC8	—	0.993	Q9TVC8 →
P06344	—	0.993	P06344 →
P06346	—	0.992	P06346 →
P18467	—	0.992	P18467 →
P01920	—	0.992	P01920 →
P13765	—	0.992	P13765 →
P23068	—	0.992	P23068 →
P20756	—	0.991	P20756 →