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Sugi Predict / Targets / HSD11B1

HSD11B1

11-beta-hydroxysteroid dehydrogenase 1 · P28845 · HSD11B1 on Sugi Atlas →

263,198 patent compounds predicted against HSD11B1, 123,311 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL114400 SCHEMBL114400 1.00 20/20
SCHEMBL114401 SCHEMBL114401 1.00 20/20
SCHEMBL116333 SCHEMBL116333 1.00 20/20
SCHEMBL116334 SCHEMBL116334 1.00 20/20
SCHEMBL116687 SCHEMBL116687 1.00 20/20
SCHEMBL116688 SCHEMBL116688 1.00 20/20
SCHEMBL116718 SCHEMBL116718 1.00 20/20
SCHEMBL116719 SCHEMBL116719 1.00 20/20
SCHEMBL116720 SCHEMBL116720 1.00 20/20
SCHEMBL115969 SCHEMBL115969 0.84 20/20
SCHEMBL115970 SCHEMBL115970 0.84 20/20
SCHEMBL116751 SCHEMBL116751 0.84 20/20
SCHEMBL115466 SCHEMBL115466 0.83 20/20
SCHEMBL115467 SCHEMBL115467 0.83 20/20
SCHEMBL115468 SCHEMBL115468 0.83 20/20
SCHEMBL116406 SCHEMBL116406 0.82 20/20
SCHEMBL116407 SCHEMBL116407 0.82 20/20
SCHEMBL116408 SCHEMBL116408 0.82 20/20
SCHEMBL116585 SCHEMBL116585 0.79 20/20
SCHEMBL116586 SCHEMBL116586 0.79 20/20

Clinical trials — most relevant to HSD11B1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Congenital Adrenal Hyperplasia Once Daily Hydrocortisone Treatment PHASE4RECRUITING
The Role of Mineralocorticoid Receptors in Vascular Function PHASE2/PHASE3COMPLETED
Androgen Reduction in Congenital Adrenal Hyperplasia PHASE2WITHDRAWN
Comparison of Two Forms of Hydrocortisone in Patients With Congenital Adrenal Hyperplasia PHASE1/PHASE2COMPLETED
Pharmacokinetics, Safety and Tolerability of Crinecerfont in Participants With Congenital Adrenal Hyperplasia Who Are Less Than 2 Years Old PHASE2ACTIVE_NOT_RECRUITING
Glucocorticoids and Skin Healing in Diabetes (GC-SHealD) PHASE2COMPLETED
11ß-HSD1 and Metabolic Syndrome PHASE2COMPLETED
A Phase 2 Study to Evaluate the Effects of ASP5541 in Participants With Prostate Cancer PHASE2RECRUITING
Metyrapone as Additive Treatment in Major Depression PHASE2COMPLETED
Linear Growth of Children With Congenital Adrenal Hyperplasia nanUNKNOWN
Pattern of Gene Expression in Adipose Tissue From Patients With Cushing Syndrome nanCOMPLETED
Biomarkers in Bone Marrow and Blood Samples From Patients With Prostate Cancer Treated With Ketoconazole nanWITHDRAWN
Effect of Surgical or Conservative Approach in Patients With Adrenal Incidentalomas nanUNKNOWN
Novel Biomarker for Development of T2D nanCOMPLETED
Final Height in Patients With CAH nanUNKNOWN
Determining the Long-Term Effects of Prenatal Dexamethasone Treatment in Children With 21-Hydroxylase Deficiency and Their Mothers nanUNKNOWN
Biomarkers in the Etiology of Idiopathic Intracranial Hypertension nanUNKNOWN
Adrenal Function in GHD Children nanCOMPLETED
Cortisol Regulation in Polycystic Ovary Syndrome (PCOS) nanCOMPLETED
Mutation Analysis of 17βhydroxysteroid Dehydrogenase 3 Deficiency nanUNKNOWN
Polycystic Ovary Syndrome in Type 1 Diabetes nanNOT_YET_RECRUITING
Natural History of Apparent Mineralocorticoid Excess Syndrome nanCOMPLETED
Fertility and Pregnancy in Patients With Classic Congenital Adrenal Hyperplasia nanCOMPLETED
Syndromes With Neonatal Salt Loss: Not Only Congenital Adrenal Hyperplasia Due to 21-hydroxylase Deficiency (21OH-ISC) nanRECRUITING
Examining Genetic Differences Among People With 21-Hydroxylase Deficiency nanCOMPLETED
Exercise Capacity, Physical Fitness, and Physical Activity Levels in Children With CAH nanCOMPLETED
Mutation Analysis of 17α-Hydroxylase nanUNKNOWN
CXCR4 Targeted PET Imaging in the Diagnosis and Identification of Primary Aldosteronism nanUNKNOWN
Fertility And Sexual Function In CAH: CALLIOPE nanRECRUITING
Chocolate and Physical Exercise to Reduce Malnutrition in Pre-dementia Aged People nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a HSD11B1 binder may also engage these)

ProteinNameSimilarity
Q29608 — 1.000 Q29608 →
Q6QLL4 — 1.000 Q6QLL4 →
P50172 — 1.000 P50172 →
Q6R0J2 — 1.000 Q6R0J2 →
P51975 — 0.999 P51975 →
Q8HZJ8 — 0.999 Q8HZJ8 →
P16232 — 0.996 P16232 →
Q7M3I4 — 0.994 Q7M3I4 →
Q6P7J1 — 0.991 Q6P7J1 →
A4IGM4 — 0.990 A4IGM4 →
Q7SYS6 — 0.989 Q7SYS6 →
Q6PUF3 — 0.986 Q6PUF3 →
P0DKC5 — 0.985 P0DKC5 →
A5PJF6 — 0.985 A5PJF6 →
P0DKC6 — 0.985 P0DKC6 →
Q6QA32 — 0.985 Q6QA32 →
Q9STY7 — 0.984 Q9STY7 →
Q7T2D1 — 0.983 Q7T2D1 →
Q80ZF7 — 0.983 Q80ZF7 →
O54939 — 0.983 O54939 →
P70385 — 0.983 P70385 →
Q4JK73 — 0.983 Q4JK73 →
Q5NVG2 — 0.983 Q5NVG2 →
Q8N3Y7 — 0.982 Q8N3Y7 →
Q8VCR2 — 0.982 Q8VCR2 →
HSD17B3 17-beta-hydroxysteroid dehydrogenase type 3 0.982 landscape →
Q5ZJG8 — 0.982 Q5ZJG8 →
Q9STY8 — 0.982 Q9STY8 →
A7LB59 — 0.982 A7LB59 →
Q5M875 — 0.982 Q5M875 →