INCENP

Inner centromere protein · Q9NQS7 · INCENP on Sugi Atlas →

14,517 patent compounds predicted against INCENP, 8,649 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Hydrochloric Acid (SCHEMBL1500997)	1.00	17/20
Hydrochloric Acid (SCHEMBL1501000)	1.00	17/20
Trifluoroacetic Acid (SCHEMBL1501006)	0.77	17/20
Trifluoroacetic Acid (SCHEMBL1056832)	0.64	17/20
SCHEMBL1501008	0.62	17/20
SCHEMBL1500998	0.53	17/20
SCHEMBL1501004	0.53	17/20
SCHEMBL1500971	0.72	16/20
SCHEMBL1500972	0.72	16/20
Trifluoroacetic Acid (SCHEMBL1055761)	0.53	16/20
SCHEMBL1500854	0.72	15/20
SCHEMBL1500855	0.72	15/20
SCHEMBL1500858	0.72	15/20
SCHEMBL527521	0.55	13/20
SCHEMBL527522	0.55	13/20
Trifluoroacetic Acid (SCHEMBL1055755)	0.55	13/20
SCHEMBL527633	0.53	13/20
SCHEMBL527634	0.53	13/20
SCHEMBL1055757	0.52	13/20
Inamrinone (SCHEMBL44012)	1.00	12/20

Clinical trials — most relevant to INCENP by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Phase I Study to Assess the Safety, Pharmacokinetics, & Pharmacodynamics of GSK923295 in Subjects w/ Refractory Cancer	PHASE1	COMPLETED
Breakpoint Analysis of de Novo Apparently Balanced Chromosomal Translocations	EARLY_PHASE1	COMPLETED
PCM1-JAK2 in Therapy Related Neoplasms	nan	UNKNOWN
Tobacco and Sperm Genome: Effects of Smoking Cessation	nan	COMPLETED
Role of Genetics in Idiopathic Pulmonary Fibrosis (IPF)	nan	UNKNOWN
Proteomic-Based Profiling of Lymphomas: Chromatin Proteomics; Composition and Modification of Histone and Non-Histone Chromosomal Proteins	nan	COMPLETED
PCD New Gene Discovery	nan	COMPLETED
Pathogenesis of Primary Ciliary Dyskinesia (PCD) Lung Disease	nan	RECRUITING
Chromosome 9 P Minus Syndrome	nan	RECRUITING
Genetics of Primary Ciliary Dyskinesia	nan	COMPLETED
Validation of Optical Genome Mapping for the Identification of Constitutional Genomic Variants in a Postnatal Cohort	nan	UNKNOWN
Cytogenetic Study of Ocular Melanoma	nan	COMPLETED
A Study Providing Genetic Testing to Find Those Who May Have Primary Ciliary Dyskinesia for Potential Clinical Trials	nan	ACTIVE_NOT_RECRUITING
Genetic Study of Patients With Primary Ciliary Dyskinesia	nan	COMPLETED
Diagnosis of Primary Ciliary Dyskinesia	nan	COMPLETED
The Contribution of Optical Mapping to the Characterization of Chromosomal Rearrangements in Patients With Neurodevelopmental Disorders	nan	RECRUITING
Classification, Functional Stratification and Biomarkers in Ciliopathy (CILLICORIRCM)	nan	COMPLETED
Inter-regional Project of the Great Western Exploration Approach for Exome Molecular Causes Severe Intellectual Disability Isolated or Syndromic	nan	COMPLETED
Natural History Evaluation of Charcot Marie Tooth Disease (CMT) Types CMT1B, CMT2A, CMT4A, CMT4C, and Others	nan	RECRUITING
Characterizing the Upper Airway Manifestations in Primary Ciliary Dyskinesia and Primary Immunodeficiencies	nan	COMPLETED
Whole Genome Scan of Extended Families With Familial Vocal Cord Paralysis	nan	COMPLETED
Molecular Profiling to Improve Outcome of Patients in Cancer. A Pilot Study	nan	COMPLETED
Prenatal Cell-free DNA Screening in Pregnancies With Diverse Genetic Risk Profiles Utilizing Targeted and Whole-exome Sequencing	nan	NOT_YET_RECRUITING
Genetic Investigation of Solid Tumors Cohort	nan	COMPLETED
Association of Previously Verified Gene Polymorphisms With AMD in Turkish Population	nan	UNKNOWN
Biological Aging Hallmarks-Guided Integrative TCM and Conventional Medicine in Post-Treatment Unexplained Female Infertility	nan	RECRUITING
Microarray Analysis in Syndromic Obesity	nan	COMPLETED
IPSC Repository of Pediatric Cardiovascular Disease	nan	RECRUITING
Telomeres Length in Israeli Fibrotic ILD Patients	nan	ENROLLING_BY_INVITATION
Development of a Newborn Screening Assay for Angelman Syndrome and Prader-Willi Syndrome	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a INCENP binder may also engage these)

Protein	Name	Similarity
Q9WU62	—	1.000	Q9WU62 →
P53352	—	0.999	P53352 →
A6QLA6	—	0.996	A6QLA6 →
Q96T17	—	0.995	Q96T17 →
Q6PCQ0	—	0.994	Q6PCQ0 →
MAP7	Ensconsin	0.994	landscape →
D4A4L4	—	0.994	D4A4L4 →
Q5ZIA2	—	0.993	Q5ZIA2 →
A0JMK9	—	0.993	A0JMK9 →
Q32N93	—	0.992	Q32N93 →
Q922B9	—	0.992	Q922B9 →
A2AHC3	—	0.992	A2AHC3 →
O88735	—	0.991	O88735 →
Q9Y6A5	—	0.991	Q9Y6A5 →
Q58CQ0	—	0.991	Q58CQ0 →
O18805	—	0.991	O18805 →
O13024	—	0.990	O13024 →
P46529	—	0.990	P46529 →
Q8CCG4	—	0.990	Q8CCG4 →
E9QG33	—	0.990	E9QG33 →
E7F5E1	—	0.990	E7F5E1 →
Q8VDP4	—	0.989	Q8VDP4 →
Q9Y6F6	—	0.989	Q9Y6F6 →
A1X157	—	0.989	A1X157 →
Q9WUX5	—	0.989	Q9WUX5 →
Q6IPM2	—	0.989	Q6IPM2 →
Q5R7F9	—	0.989	Q5R7F9 →
Q0IHP2	—	0.989	Q0IHP2 →
Q9JHU2	—	0.989	Q9JHU2 →
Q5RG44	—	0.989	Q5RG44 →