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Sugi Predict / Targets / KCNMB1

KCNMB1

Large conductance calcium-activated potassium channel subfamily M beta member 1 · Q16558 · KCNMB1 on Sugi Atlas →

1,240 patent compounds predicted against KCNMB1, 1,075 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL22637576 SCHEMBL22637576 1.00 1/20
SCHEMBL22637578 SCHEMBL22637578 1.00 1/20
SCHEMBL24660636 SCHEMBL24660636 1.00 1/20
SCHEMBL24660192 SCHEMBL24660192 0.86 1/20
SCHEMBL24660543 SCHEMBL24660543 0.86 1/20
SCHEMBL24660574 SCHEMBL24660574 0.86 1/20
SCHEMBL24660722 SCHEMBL24660722 0.86 1/20
SCHEMBL22637968 SCHEMBL22637968 0.85 1/20
SCHEMBL22637970 SCHEMBL22637970 0.85 1/20
SCHEMBL22637271 SCHEMBL22637271 0.84 1/20
SCHEMBL22637275 SCHEMBL22637275 0.84 1/20
SCHEMBL22637917 SCHEMBL22637917 0.84 1/20
SCHEMBL22637922 SCHEMBL22637922 0.84 1/20
SCHEMBL22637499 SCHEMBL22637499 0.83 1/20
SCHEMBL22637501 SCHEMBL22637501 0.83 1/20
SCHEMBL22637787 SCHEMBL22637787 0.83 1/20
SCHEMBL22637792 SCHEMBL22637792 0.83 1/20
SCHEMBL24660767 SCHEMBL24660767 0.83 1/20
SCHEMBL22637201 SCHEMBL22637201 0.82 1/20
SCHEMBL22637372 SCHEMBL22637372 0.82 1/20

Clinical trials — most relevant to KCNMB1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Sulphonylurea Receptor Mutation and Responsiveness to Gliclazide - a Pilot Proof of Concept, Randomised Cross-over Study PHASE4COMPLETED
Role of Eplerenone in Reducing Recurrence of Atrial Fibrillation in Patient With Structural Heart Disease PHASE4NOT_YET_RECRUITING
Effect of Amiodarone on the Procedure Outcome in Long-standing Persistent Atrial Fibrillation Undergoing Pulmonary Vein Antral Isolation PHASE3COMPLETED
Levosimendan in Acute Decompensated Heart Failure PHASE2/PHASE3NOT_YET_RECRUITING
A First-in-human Study of S230815 in Pediatric Participants With KCNT1-related Developmental and Epileptic Encephalopathy PHASE1/PHASE2RECRUITING
4-Aminopyridine in Episodic Ataxia Type 2 PHASE2WITHDRAWN
Mutation-specific Therapy for the Long QT Syndrome PHASE2COMPLETED
Safety, Blood Levels and Effects of AUT00201 in Patients With MEAK PHASE1COMPLETED
Evaluation of the Effects of KCNQ1 Mutation on Insulin Tolerance and Obsessive Compulsive Features in Long QT Romano-Ward Syndrome Patients. nanUNKNOWN
Genetic Analysis of Heart Channelopathies in Brazilian Patients and Their Relatives nanUNKNOWN
Genetic Determinants of Sudden Cardiac Death nanCOMPLETED
The Physiological Effects of Human Ether-a-go-go-Related Gene (hERG)Blockade on Metabolism nanCOMPLETED
The Involvement of ATP Sensitive Potassium Channel in Migraine Aura and Migraine Pain. nanUNKNOWN
A Cohort Study on the Prognosis of Neonatal KCNQ2 Gene-associated Epileptic Encephalopathy nanUNKNOWN
The Effects of the Anti Nausea Drugs Droperidol and Ondansetron on the Way the Heart Recovers Between Beats nanCOMPLETED
Characteristics of Episodic Ataxia Syndrome nanCOMPLETED
The Effects of the Anesthetic Drug Propofol on the Way the Heart Recovers Between Beats nanCOMPLETED
Gene Study for Infantile Onset Diabetes nanUNKNOWN
Role of Nitric Oxide in Diabetic Patients With Erectile Dysfunction nanCOMPLETED
Gene-STEPS: Shortening Time of Evaluation in Paediatric Epilepsy Services nanUNKNOWN
Transcriptomic Profile of Patients Treated With Different Modalities of Spinal Cord Stimulation nanUNKNOWN
Qatar Cardiovascular Biorepository of AF Patients nanUNKNOWN
ST-segment Elevation as an AF Endophenotype nanCOMPLETED
Targeting Potassium Channels to Reprogram Glioblastoma Microenvironment: in Vitro and in Vivo Studies nanUNKNOWN
Impact of Sulphonylureas on Neurodevelopmental Outcomes in KCNJ11-related Intermediate Developmental Delay, Epilepsy and Neonatal Diabetes (iDEND) Syndrome nanRECRUITING
The Prevalence of RYR1-related Disease nanNOT_YET_RECRUITING
Genetic Study for Infantile Onset Diabetes Mellitus nanUNKNOWN
Sodium Channel Splicing in Obstructive Sleep Apnea (SOCS-OSA) nanCOMPLETED
Factors Affecting Salt Intake in Young Adults nanUNKNOWN
Characteristics of Andersen-Tawil Syndrome nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a KCNMB1 binder may also engage these)

ProteinNameSimilarity
P97678 — 1.000 P97678 →
Q8CAE3 — 1.000 Q8CAE3 →
O46372 — 1.000 O46372 →
Q28266 — 1.000 Q28266 →
Q28067 — 1.000 Q28067 →
Q98855 — 0.990 Q98855 →
Q9CRG1 — 0.978 Q9CRG1 →
Q8BXT9 — 0.978 Q8BXT9 →
P36380 — 0.977 P36380 →
A1L3G9 — 0.976 A1L3G9 →
P49222 — 0.976 P49222 →
Q5T197 — 0.976 Q5T197 →
Q9NS93 — 0.976 Q9NS93 →
O46510 — 0.976 O46510 →
Q8BG22 — 0.975 Q8BG22 →
P58873 — 0.975 P58873 →
Q9DBX3 — 0.974 Q9DBX3 →
Q9H295 — 0.974 Q9H295 →
Q5FWS4 — 0.974 Q5FWS4 →
Q9NZD1 — 0.974 Q9NZD1 →
Q059Y8 — 0.974 Q059Y8 →
Q9DCE9 — 0.974 Q9DCE9 →
Q96DZ7 — 0.974 Q96DZ7 →
Q6PEY0 — 0.974 Q6PEY0 →
Q2YDM8 — 0.973 Q2YDM8 →
Q6W3E5 — 0.973 Q6W3E5 →
O95377 — 0.973 O95377 →
Q61586 — 0.973 Q61586 →
E9Q9H8 — 0.973 E9Q9H8 →
Q8C9E8 — 0.973 Q8C9E8 →