KIF23

Kinesin-like protein KIF23 · Q02241 · KIF23 on Sugi Atlas →

1,420 patent compounds predicted against KIF23, 1,180 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Azd-4877 (SCHEMBL360703)	1.00	1/20
Azd-4877 (SCHEMBL360704)	1.00	1/20
Azd-4877 (SCHEMBL3867651)	1.00	1/20
Azd-4877 (SCHEMBL3875692)	0.98	1/20
Azd-4877 (SCHEMBL3875689)	0.97	1/20
SCHEMBL3863626	0.91	1/20
SCHEMBL3863629	0.91	1/20
SCHEMBL3870011	0.91	1/20
Hydrochloric Acid (SCHEMBL3875151)	0.89	1/20
SCHEMBL3865042	0.88	1/20
SCHEMBL3865044	0.88	1/20
SCHEMBL3869606	0.88	1/20
Hydrochloric Acid (SCHEMBL3875148)	0.88	1/20
Hydrochloric Acid (SCHEMBL3868959)	0.87	1/20
Hydrochloric Acid (SCHEMBL3868956)	0.86	1/20
SCHEMBL3866748	0.85	1/20
SCHEMBL3866751	0.85	1/20
SCHEMBL3872501	0.85	1/20
SCHEMBL3867276	0.85	1/20
SCHEMBL3867277	0.85	1/20

Clinical trials — most relevant to KIF23 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
A Phase II Multicenter, Randomized, Placebo Controlled, Double Blinded Clinical Study of KD018 as a Modulator of Irinotecan Chemotherapy in Patients With Metastatic Colorectal Cancer	PHASE2	COMPLETED
A Study to Investigate Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy With GenSci122 in Participants With Advanced Solid Tumors	PHASE1	RECRUITING
Functional Studies of Novel Genes Mutated in Primary Ciliary Dyskinesia II: Genotype to Phenotype	EARLY_PHASE1	COMPLETED
Genetic Study of Patients With Primary Ciliary Dyskinesia	nan	COMPLETED
Better Delineation of CDK13 Related Phenotype and Epigenetic Signature.	nan	UNKNOWN
Biomarker Research in Inherited Movement Disorders	nan	RECRUITING
Progressive Familial Intrahepatic Cholestasis in Indian Children - Establishing an Indian PFIC Registry	nan	UNKNOWN
Delineating the Molecular Spectrum and the Clinical, Imaging and Neuronal Phenotype of Chopra-Amiel-Gordon Syndrome	nan	RECRUITING
Evaluation and Treatment of Pediatric, Developmental, and Genetic Eye Diseases	nan	COMPLETED
Hong Kong Spinocerebellar Ataxias Registry	nan	RECRUITING
Genetics of Primary Ciliary Dyskinesia	nan	COMPLETED
Prospective Analysis of the Treatment of Progressive Familial Intrahepatic Cholestasis (TreatFIC)	nan	RECRUITING
Clinical Registry Investigating Bardet-Biedl Syndrome	nan	RECRUITING
Core Stability Exercises and Hereditary Ataxia	nan	COMPLETED
Natural History Evaluation of Charcot Marie Tooth Disease (CMT) Types CMT1B, CMT2A, CMT4A, CMT4C, and Others	nan	RECRUITING
Classification, Functional Stratification and Biomarkers in Ciliopathy (CILLICORIRCM)	nan	COMPLETED
Gait in Rare Diseases	nan	COMPLETED
PCD New Gene Discovery	nan	COMPLETED
Spastic Paraplegia - Centers of Excellence Research Network	nan	RECRUITING
Importance of the Microtubule Cytoskeleton in Oocyte Competence	nan	COMPLETED
Pathogenesis of Primary Ciliary Dyskinesia (PCD) Lung Disease	nan	RECRUITING
Assessing the Polygenic Burden of Rare Disruptive Mutations in Parkinson's Disease	nan	UNKNOWN
Registry and Natural History of Epilepsy-Dyskinesia Syndromes	nan	RECRUITING
Genetics of Pediatric-Onset Motor Neuron and Neuromuscular Diseases	nan	COMPLETED
iPSC Neurons From Adult Survivors of Childhood Cancer Who Have Persistent Vincristine-Induced Neuropathy	nan	COMPLETED
A Retrospective Survey-based Multicenter Study to Delineate the Molecular and Phenotypic Spectrum of Epilepsy-dyskinesia Syndromes	nan	RECRUITING
Diagnosis of Primary Ciliary Dyskinesia	nan	COMPLETED
Mapping Disease Pathways for Biliary Atresia	nan	RECRUITING
Evaluation of Children With Endocrine and Metabolic-Related Conditions	nan	RECRUITING
Exploring a Motor Learning Technique Based on the Mirror Motor Neuron System	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a KIF23 binder may also engage these)

Protein	Name	Similarity
E9Q5G3	—	1.000	E9Q5G3 →
Q9UPW8	—	0.977	Q9UPW8 →
Q4KUS2	—	0.977	Q4KUS2 →
Q921D9	—	0.977	Q921D9 →
Q8BWW9	—	0.977	Q8BWW9 →
Q9Z1N9	—	0.977	Q9Z1N9 →
Q58A65	—	0.977	Q58A65 →
A7MBL8	—	0.976	A7MBL8 →
PI4KB	Phosphatidylinositol 4-kinase beta	0.976	landscape →
Q62768	—	0.976	Q62768 →
A6NI28	—	0.976	A6NI28 →
Q8QFR2	—	0.975	Q8QFR2 →
Q9H8E8	—	0.975	Q9H8E8 →
Q9Z1T4	—	0.975	Q9Z1T4 →
PKN2	Serine/threonine-protein kinase N2	0.974	landscape →
A4IID4	—	0.974	A4IID4 →
B0KWC1	—	0.974	B0KWC1 →
Q6PCS4	—	0.974	Q6PCS4 →
TLK2	Serine/threonine-protein kinase tousled-like 2	0.974	landscape →
B1MTG7	—	0.974	B1MTG7 →
Q69ZT9	—	0.974	Q69ZT9 →
O08561	—	0.974	O08561 →
Q90ZY6	—	0.974	Q90ZY6 →
Q9GKY8	—	0.974	Q9GKY8 →
Q6PBM7	—	0.974	Q6PBM7 →
Q9ESL4	—	0.973	Q9ESL4 →
Q8WXG6	—	0.973	Q8WXG6 →
O14795	—	0.973	O14795 →
Q6ISB3	—	0.973	Q6ISB3 →
Q07722	—	0.973	Q07722 →