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LHCGR

Lutropin-choriogonadotropic hormone receptor · P22888 · LHCGR on Sugi Atlas →

3,797 patent compounds predicted against LHCGR, 2,742 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL4432570 SCHEMBL4432570 0.67 18/20
SCHEMBL4563299 SCHEMBL4563299 0.64 17/20
SCHEMBL2306419 SCHEMBL2306419 0.57 17/20
SCHEMBL2305377 SCHEMBL2305377 0.53 17/20
SCHEMBL2306784 SCHEMBL2306784 0.49 17/20
SCHEMBL2308119 SCHEMBL2308119 0.63 16/20
SCHEMBL2308933 SCHEMBL2308933 0.58 16/20
SCHEMBL4429897 SCHEMBL4429897 0.80 15/20
SCHEMBL2309079 SCHEMBL2309079 0.77 15/20
SCHEMBL3365428 SCHEMBL3365428 0.63 15/20
SCHEMBL2307120 SCHEMBL2307120 0.51 15/20
SCHEMBL2310558 SCHEMBL2310558 0.50 15/20
SCHEMBL4425858 SCHEMBL4425858 0.71 14/20
SCHEMBL2304299 SCHEMBL2304299 0.52 14/20
SCHEMBL2312192 SCHEMBL2312192 0.52 14/20
SCHEMBL2307691 SCHEMBL2307691 0.49 14/20
SCHEMBL4425902 SCHEMBL4425902 0.78 13/20
SCHEMBL4429274 SCHEMBL4429274 0.66 13/20
SCHEMBL2306538 SCHEMBL2306538 0.64 13/20
SCHEMBL2305817 SCHEMBL2305817 0.58 13/20

Clinical trials — most relevant to LHCGR by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
the Effects of GnRHa Add up to Routine Luteal Phase Support on Frozen Embryo Implantation in Frozen Embryo Transfer . PHASE4UNKNOWN
Gonadotropin Type in Ovarian Stimulation PHASE4COMPLETED
The Effectiveness and Safety of the Prolonged Down-regulation Protocol for Controlled Ovarian Hyperstimulation PHASE4UNKNOWN
Ulipristal Versus Placebo for Women With Bleeding Induced by Mirena PHASE4UNKNOWN
Efficacy of Recombinant FSH/GnRH Antagonist Protocol With and Without LH Adjunct for Egg Bank Donation PHASE4COMPLETED
Investigating the Potential Role of Aerosolized Retinoic Acid, a Potent Vitamin A Metabolite for Treating COVID-19 Anosmia and Retinoic Acid Insufficiency .A Novel Approach for Regaining Sense of Smell. PHASE4UNKNOWN
Optimal Stimulation of Hypo-responders Undergoing in Vitro Fertilization (IVF) PHASE4NOT_YET_RECRUITING
INTEnsity of ovariaN Stimulation and Embryo Quality PHASE4COMPLETED
HCG (Human Chorionic Gonadotropin) Priming for Thin Endometrium in IVF (in Vitro Fertilization) PHASE4UNKNOWN
Luteal Phase Support With GnRH Agonist After GnRH Agonist Triggering in IVF/ICSI Cycles PHASE3RECRUITING
A Pharmacodynamic Study of Leuprorelin Gelatin-Free Formulation in Female Subjects With Uterine Fibroids. PHASE2COMPLETED
TRial on the Endocrine Activity of Neoadjuvant Degarelix PHASE2COMPLETED
Lutropin Alfa in Women at Risk of Poor Response PHASE2COMPLETED
Luteal Phase Support With Daily Administration of Gonadotropin-releasing Hormone Agonist Compared to Progesterone/Estradiol in IVF/ICSI Cycles With Ovulation Triggering With GnRH-a PHASE2UNKNOWN
Effect of GnRH Agonist in FET PHASE1/PHASE2NOT_YET_RECRUITING
Neoadjuvant Goserelin for Triple Negative Breast Cancer PHASE2UNKNOWN
Extragonadal Effects of hCG on Calcium Homeostasis PHASE1COMPLETED
Trial of Xaluritamig in Adults With Metastatic Castration-resistant Prostate Cancer PHASE1RECRUITING
Comparison of Pregnancy Rates in Modified Natural Frozen Embryo Transfer (FET) Cycle After Luteal Support with GnRH Agonist Versus Progesterone EARLY_PHASE1NOT_YET_RECRUITING
Cost Effectiveness Analysis for Induction of Ovulation in the Polycystic Ovary Syndrome by Letrozole Versus Clomiphene Citrate EARLY_PHASE1UNKNOWN
Calciotropic Effects After HCG Stimulation Test nanCOMPLETED
Mechanisms of Increased Androgen Production Among Women With Polycystic Ovary Syndrome nanCOMPLETED
A Proof of Concept Study of Serum Progesterone Levels for IVF/ICSI Following HCG Trigger for Oocyte Maturation nanCOMPLETED
OvS Breast: Ovarian Suppression in Breast Cancer Interventions nanRECRUITING
A Post Marketing Assessment of Gonal f Solution for Injection in a Prefilled Pen for Follicular Stimulation in in Vitro Fertilisation/Embryo Transfer (IVF-ET) Cycles nanCOMPLETED
Dydrogesterone Versus Intravaginal Progesterone in the Luteal Phase Support nanCOMPLETED
GnRH for Luteal Support - Mechanism of Action nanRECRUITING
Plasma Analysis for Response Assessment and to DIrect the manaGement of Metastatic Prostate Cancer nanACTIVE_NOT_RECRUITING
Agonist Versus Classical HCG Trigger (Poor Responders, Normoresponders and High Responders) nanUNKNOWN
CIRCULATING MICRO-RNA (miRNA) AND AR-V7 MUTATIONAL STATUS IN METASTATIC CASTRATION-RESISTANT PROSTATE CANCER (CRPC): PRIMERA+ STUDY (PROSTATE CANCER INNOVATING MARKERS OF EXPECTED RESPONSE TO AGONIST LHRH+ ANDROGEN RECEPTOR INHIBITION nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a LHCGR binder may also engage these)

ProteinNameSimilarity
P16582 — 1.000 P16582 →
Q9BGN4 — 1.000 Q9BGN4 →
O02721 — 1.000 O02721 →
P14763 — 1.000 P14763 →
TSHR Thyrotropin receptor 1.000 landscape →
Q28005 — 1.000 Q28005 →
Q27987 — 1.000 Q27987 →
P47750 — 0.999 P47750 →
P21463 — 0.998 P21463 →
P30730 — 0.998 P30730 →
Q6QMG1 — 0.998 Q6QMG1 →
Q6R6L8 — 0.997 Q6R6L8 →
P16235 — 0.997 P16235 →
Q90674 — 0.997 Q90674 →
Q8SPP9 — 0.997 Q8SPP9 →
P56495 — 0.995 P56495 →
P47799 — 0.993 P47799 →
Q28585 — 0.993 Q28585 →
P20395 — 0.992 P20395 →
P35378 — 0.992 P35378 →
Q95179 — 0.992 Q95179 →
Q6YNB6 — 0.989 Q6YNB6 →
P49059 — 0.989 P49059 →
Q8R428 — 0.985 Q8R428 →
FSHR Follicle-stimulating hormone receptor 0.985 landscape →
P35376 — 0.984 P35376 →
P32212 — 0.983 P32212 →
RXFP2 Relaxin receptor 2 0.982 landscape →
Q5XM32 — 0.982 Q5XM32 →
Q91ZZ5 — 0.981 Q91ZZ5 →