Sugi Predict

Sugi Predict / Targets / MAT2A

MAT2A

S-adenosylmethionine synthase isoform type-2 · P31153 · MAT2A on Sugi Atlas →

26,381 patent compounds predicted against MAT2A, 8,377 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL1144571 SCHEMBL1144571 0.51 17/20
SCHEMBL1144494 SCHEMBL1144494 0.51 15/20
SCHEMBL672218 SCHEMBL672218 0.46 13/20
SCHEMBL673296 SCHEMBL673296 0.45 12/20
SCHEMBL671724 SCHEMBL671724 0.42 12/20
SCHEMBL671281 SCHEMBL671281 0.43 11/20
SCHEMBL670405 SCHEMBL670405 0.43 11/20
SCHEMBL670754 SCHEMBL670754 0.45 10/20
SCHEMBL671374 SCHEMBL671374 0.43 10/20
SCHEMBL671627 SCHEMBL671627 0.42 10/20
SCHEMBL1694681 SCHEMBL1694681 0.66 9/20
SCHEMBL1695118 SCHEMBL1695118 0.55 9/20
SCHEMBL1695004 SCHEMBL1695004 0.52 9/20
SCHEMBL670739 SCHEMBL670739 0.46 9/20
SCHEMBL671004 SCHEMBL671004 0.46 9/20
SCHEMBL670444 SCHEMBL670444 0.43 9/20
SCHEMBL670590 SCHEMBL670590 0.42 8/20
SCHEMBL671198 SCHEMBL671198 0.42 8/20
SCHEMBL181585 SCHEMBL181585 0.37 8/20
SCHEMBL670399 SCHEMBL670399 0.46 7/20

Clinical trials — most relevant to MAT2A by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Folic Acid and Creatine as Therapeutic Approaches for Lowering Blood Arsenic PHASE4COMPLETED
Treatment With Azacitidine of Recurrent Gliomas With IDH1/2 Mutation PHASE2UNKNOWN
Safety and Efficacy of BMS-986504 in Unresectable Malignant Peripheral Nerve Sheath Tumor PHASE1/PHASE2NOT_YET_RECRUITING
Folate Rechallenge PHASE2COMPLETED
Phase I Trial of 4'-Thio-2'-Deoxycytidine (TdCyd) in Patients With Advanced Solid Tumors PHASE1COMPLETED
5-aza-4'-Thio-2'-Deoxycytidine (Aza-TdC) in People With Advanced Solid Tumors PHASE1RECRUITING
A Study of the Interaction Between Tumor Susceptibility Gene Glycine N-methyltransferase (GNMT) and Lung Cancer nanUNKNOWN
Role of a Dietary Supplement in Lowering SAH in Healthy Adults With Elevated Plasma SAH and Normal Homocysteine Levels nanCOMPLETED
Plant-based Diets and Body Weight and Selected Metabolic Parameters Management in Obese Patients. nanCOMPLETED
Efficacy of Essential Phospholipid Versus Betaine HCL/L-Glutamic Acid in MAFLD nanNOT_YET_RECRUITING
Harmonized Micronutrient Project nanCOMPLETED
Role and Interactions of Adenosine, Receptors, Methionine Cycle Nutritional, Metabolic and Genetic Determinants in the Onset of Atrial Fibrillation in Normal Heart nanUNKNOWN
Dietary Effects of Sulfur Amino Acids nanCOMPLETED
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation nanCOMPLETED
DNA Methylation and Autoimmune Thyroid Diseases nanCOMPLETED
EnBrace HR for Depression Treatment and Prevention in Women Trying to Conceive and Early Pregnancy nanCOMPLETED
S-adenosylmethionine Plus Choline in Treatment of Patients With Alcoholic Liver Disease nanUNKNOWN
Investigation of Methylation of EGFR in the Response of the Cetuximab in Metastatic Colorectal Cancer Patients nanCOMPLETED
Impact Of Choline in Patients With NAFLD nanUNKNOWN
Effect of Sulfur Amino Acid Depletion and Acetaminophen on Plasma Glutatione nanCOMPLETED
Melatonin in Pregnancy nanCOMPLETED
Adenosylmethionine Metabolism in Human Inflammation nanUNKNOWN
Nitric Oxide Supplementation on Neurocognitive Functions in Patients With ASLD nanCOMPLETED
Genetic Study of Familial Factors in Patients With Colon Cancer nanCOMPLETED
Proof of Concept Creatine Supplementation for Homocystinuria Study nanACTIVE_NOT_RECRUITING
Effectiveness of Comprehensive Tertiary Interventions on Incidence and Clinical Outcomes of Birth Defects nanCOMPLETED
Presence of Cyclopropane Fatty Acids (CPFA) in Human Plasma nanCOMPLETED
Genetics and Epigenetics of Graves' Orbitopathy nanCOMPLETED
Investigation of the Genetic and Environmental Causes of Autism: a Multi-Center Study nanNOT_YET_RECRUITING
5-methyltetrahydrofolate Survival and Inflammation in ESRD Patients nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a MAT2A binder may also engage these)

ProteinNameSimilarity
Q3THS6 — 1.000 Q3THS6 →
P18298 — 1.000 P18298 →
Q5R5H1 — 1.000 Q5R5H1 →
P0A819 — 1.000 P0A819 →
B5YQD9 — 1.000 B5YQD9 →
B7LFK4 — 1.000 B7LFK4 →
B7NI05 — 1.000 B7NI05 →
A8A481 — 1.000 A8A481 →
Q3YXS9 — 1.000 Q3YXS9 →
B7N7J5 — 1.000 B7N7J5 →
P66764 — 1.000 P66764 →
B5FUK0 — 1.000 B5FUK0 →
B7LYX2 — 1.000 B7LYX2 →
C5A0L1 — 1.000 C5A0L1 →
B1IT65 — 1.000 B1IT65 →
B1XFA4 — 1.000 B1XFA4 →
A5F9H4 — 1.000 A5F9H4 →
Q2KJC6 — 1.000 Q2KJC6 →
B4TV58 — 1.000 B4TV58 →
P66765 — 1.000 P66765 →
B5BFP7 — 1.000 B5BFP7 →
C5D6E9 — 1.000 C5D6E9 →
Q98A80 — 1.000 Q98A80 →
Q7N119 — 1.000 Q7N119 →
Q7VFY5 — 1.000 Q7VFY5 →
B0BQ17 — 1.000 B0BQ17 →
A1SZJ9 — 1.000 A1SZJ9 →
A4T0F0 — 1.000 A4T0F0 →
Q95032 — 1.000 Q95032 →
A5UIU0 — 1.000 A5UIU0 →