METAP2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Fumagillin (SCHEMBL8130)	1.00	18/20
SCHEMBL8129	0.75	18/20
SCHEMBL4739	0.55	18/20
SCHEMBL124947	1.00	11/20
SCHEMBL124265	0.78	9/20
SCHEMBL124267	0.78	9/20
SCHEMBL124391	0.78	9/20
SCHEMBL124197	0.67	9/20
SCHEMBL104083	0.64	9/20
SCHEMBL125201	0.62	9/20
SCHEMBL124343	0.61	9/20
SCHEMBL179138	0.61	9/20
SCHEMBL125111	0.57	9/20
SCHEMBL125289	0.56	9/20
SCHEMBL124228	0.71	8/20
SCHEMBL179142	0.68	8/20
SCHEMBL125153	0.65	8/20
SCHEMBL179095	0.62	8/20
SCHEMBL125154	0.60	8/20
SCHEMBL125806	0.58	8/20

Clinical trials — most relevant to METAP2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Pharmacogenomic Evaluation of Antihypertensive Responses	PHASE4	COMPLETED
Effect of Sitagliptin and an ACE Inhibitor on Blood Pressure in Metabolic Syndrome	PHASE4	COMPLETED
A Trial of CM-AT in Children With Autism With All Levels of FCT (The Blum Study)	PHASE3	COMPLETED
Efficacy and Safety of SYR-472 in Subjects With Type 2 Diabetes Mellitus	PHASE2	COMPLETED
Role of TLR4 in Environmental Asthma	PHASE1	COMPLETED
Family Blood Pressure Program - GenNet Network	nan	COMPLETED
Family Blood Pressure Program - HyperGEN	nan	COMPLETED
Family Blood Pressure Program - SAPPHIRe Network	nan	COMPLETED
Pharmacogenomic Response to Thyrotropin-Releasing Hormone Stimulation in Healthy Volunteers: The Influence of a Common Type 2 Deiodinase Genetic Polymorphism on Serum T3	nan	COMPLETED
Genetic Characterization of Parkinson's Disease	nan	COMPLETED
Molecular & Clinical Evaluation of Low HDL Syndromes	nan	COMPLETED
Chromosome 5Q Gene Variants and Asthma-Related Traits	nan	COMPLETED
Genetic Variants and Regulation of Specialized Pro-resolving Mediator	nan	RECRUITING
Family Blood Pressure Program - GENOA	nan	COMPLETED
PROOF: Pancreatitis-associated Risk Of Organ Failure	nan	COMPLETED
Diet, Genetics, and CVD Risk Factor Response in Blacks	nan	COMPLETED
Molecular Epidemiology of Essential Hypertension	nan	COMPLETED
Genetic Variations That Increase the Risk for Calcium Kidney Stones: a Family-based Study	nan	COMPLETED
Analysis of Genes That Predispose People to Develop High Blood Pressure	nan	COMPLETED
Genetic Basis of Mitral Valve Prolapse	nan	UNKNOWN
Using Next-generation Sequencing in the Diagnosis of Epilepsy and/or Intellectual Disability in a Pediatric Cohorte	nan	COMPLETED
The Role of Quantitative CT and Radiomic Biomarkers for Precision Medicine in Pulmonary Fibrosis	nan	RECRUITING
Dietary and Genetic Factors in Asthma & Chronic Bronchitis in a Cohort of Chinese Singaporeans	nan	COMPLETED
EndotyPIng PreHospitAl de Novo Acute hYpoxemic Respiratory Failure	nan	RECRUITING
Epidemiological and Genetic Studies of Body Mass Index	nan	COMPLETED
Integrated Proteomic HPLC-ESI-MS Analysis of Salivary Peptides of Preterm Newborns: a Pilot Study	nan	COMPLETED
Development of Biomarker for Development of Non-Alcoholic Steatohepatitis (NASH) in Children	nan	WITHDRAWN
The Genetics of Environmental Asthma	nan	COMPLETED
Identification of an Asthma Susceptibility Gene on 3P	nan	COMPLETED
EV Based Platform for Monitoring Therapeutics Response During Pregnancy (ARISE)	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a METAP2 binder may also engage these)

Protein	Name	Similarity
O08663	—	1.000	O08663 →
P38062	—	0.998	P38062 →
Q56Y85	—	0.998	Q56Y85 →
Q3ZC89	—	0.997	Q3ZC89 →
O60085	—	0.996	O60085 →
C5DE35	—	0.995	C5DE35 →
H1UBK1	—	0.995	H1UBK1 →
D8PR70	—	0.993	D8PR70 →
E3L3Q8	—	0.993	E3L3Q8 →
E5R3Z8	—	0.993	E5R3Z8 →
C9SB49	—	0.993	C9SB49 →
C0SIM8	—	0.992	C0SIM8 →
C5GCN0	—	0.992	C5GCN0 →
C1HAB2	—	0.992	C1HAB2 →
C5JW60	—	0.992	C5JW60 →
B8NA06	—	0.992	B8NA06 →
C8Z3V4	—	0.992	C8Z3V4 →
A4RDI6	—	0.992	A4RDI6 →
B2W1N6	—	0.991	B2W1N6 →
Q0CL94	—	0.991	Q0CL94 →
Q6CP80	—	0.991	Q6CP80 →
C4Y1F8	—	0.991	C4Y1F8 →
E3RCY7	—	0.991	E3RCY7 →
Q9FV49	—	0.991	Q9FV49 →
Q55C21	—	0.991	Q55C21 →
C1GLM4	—	0.991	C1GLM4 →
A8QBZ2	—	0.990	A8QBZ2 →
A1DA84	—	0.990	A1DA84 →
B5VDQ0	—	0.990	B5VDQ0 →
Q5B4X6	—	0.990	Q5B4X6 →