MUSK

Muscle, skeletal receptor tyrosine-protein kinase · O15146 · MUSK on Sugi Atlas →

17,044 patent compounds predicted against MUSK, 15,061 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Quizartinib (SCHEMBL72923)	1.00	1/20
Doramapimod (SCHEMBL129721)	1.00	1/20
Dovitinib (SCHEMBL172687)	1.00	1/20
Fedratinib (SCHEMBL263741)	1.00	1/20
Foretinib (SCHEMBL371804)	1.00	1/20
Quizartinib (SCHEMBL74121)	0.99	1/20
Dovitinib (SCHEMBL248083)	0.98	1/20
SCHEMBL73633	0.93	1/20
SCHEMBL72924	0.91	1/20
SCHEMBL295302	0.90	1/20
Hydrochloric Acid (SCHEMBL74122)	0.90	1/20
SCHEMBL295792	0.89	1/20
SCHEMBL73035	0.88	1/20
SCHEMBL73476	0.88	1/20
SCHEMBL74273	0.87	1/20
Hydrochloric Acid (SCHEMBL73806)	0.87	1/20
Hydrochloric Acid (SCHEMBL74399)	0.87	1/20
SCHEMBL371758	0.87	1/20
SCHEMBL295694	0.86	1/20
SCHEMBL371959	0.86	1/20

Clinical trials — most relevant to MUSK by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
The Effect of the Preoperative Oral Carbohydrate Attenuating Immediate Postoperative Insulin Resistance on PI3K Dependent Signaling Pathway	PHASE4	COMPLETED
Molecular Mechanisms of Type 2 Diabetes Mellitus	PHASE4	COMPLETED
Mitochondrial Oxidation and Insulin Resistance in Burn Patients Treated With Fenofibrate	PHASE2/PHASE3	WITHDRAWN
A Study to Assess the Safety, Tolerability, Efficacy, Pharmacokinetics, and Immunogenicity of Intravenous Administration of ARGX-119 in Pediatric Participants Aged 5 to Less Than 18 Years With Spinal Muscular Atrophy	PHASE2	RECRUITING
Biased GRK Signaling Via β2-Adrenergic Receptors in Human Skeletal Muscle	PHASE2	NOT_YET_RECRUITING
Vibration Therapy Effects on Muscle Firing Patterns	PHASE1/PHASE2	COMPLETED
Acute Effect of HP-211 (Axulin) on Blood Glucose and Serum Insulin Responses in Healthy Lean and Overweight Humans	PHASE1	COMPLETED
Evaluating MED2005 & Nitrostat Bioavailability	PHASE1	COMPLETED
Skeletal Muscle Mitochondrial Abnormalities and the Metabolic Syndrome in PAH	nan	COMPLETED
Defective Atypical Protein Kinase C (PKC) Activation in Diabetes and Metabolic Syndrome	nan	COMPLETED
Effects of Growth Hormone and IGF-1 on Anabolic Signals and Stem Cell Recruitment in Human Skeletal Muscle	nan	UNKNOWN
MOLECULAR REGULATION OF MUSCLE GLUCOSE METABOLISM (AIMS 2A, 2B, 3)	nan	UNKNOWN
Role of MicroRNAs on Age and Contraction-induced Skeletal Muscle Growth	nan	COMPLETED
Substrate Utilization, Exercise Performance, and Skeletal Muscle Response to Energy Deficit and Altitude Acclimatization	nan	COMPLETED
Mechanisms of Exercise Resistance in Metabolic Disease	nan	COMPLETED
The Effect of Ketone Esters on Forearm Glucose Metabolism	nan	ACTIVE_NOT_RECRUITING
Impact of Insulin Deprivation and Hyperglycemia on Plasma Protein Synthesis in People With Type 1 Diabetes Mellitus	nan	NOT_YET_RECRUITING
Muscle Response to High Intensity Interval Resistance Training (HIIRT)	nan	COMPLETED
Muscle Dysfunction in Gastrointestinal or Hepatobiliary Cancer	nan	ACTIVE_NOT_RECRUITING
Presymptomatic Neuromuscular Junction Defects and Compensatory Mechanisms in ALS	nan	UNKNOWN
In Vivo Analysis of Muscle Stem Cells in Chronic and Acute Lower Limb Ischemia (MyostemIschemia)	nan	COMPLETED
Metabolism of Ornithine Phenylacetate	nan	COMPLETED
Causes of Peripheral Hypotonia in Assiut University Children Hospital	nan	UNKNOWN
Muscle Dysfunction in Patients With Hematological Diseases Referred to Stem Cell Transplant	nan	ACTIVE_NOT_RECRUITING
Molecular Mechanisms of Exercise Benefits to Insulin Resistant People	nan	COMPLETED
B3 for NMD: Bench to Bedside and Back	nan	ENROLLING_BY_INVITATION
Muscle Atrophy In Patients With Chronic Obstructive Pulmonary Disease	nan	UNKNOWN
Muscle Dysfunction in Patients With Haematological Diseases	nan	ACTIVE_NOT_RECRUITING
Spinal Muscular Atrophy (SMA) Biomarkers Study in the Immediate Postnatal Period of Development	nan	COMPLETED
The Incorporation of Dietary Protein-Derived Amino Acids in Duodenal Epithelium	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a MUSK binder may also engage these)

Protein	Name	Similarity
Q62838	—	1.000	Q62838 →
Q61006	—	1.000	Q61006 →
Q8JFR5	—	0.999	Q8JFR5 →
Q00495	—	0.998	Q00495 →
P35546	—	0.997	P35546 →
Q8AXY6	—	0.997	Q8AXY6 →
Q28889	—	0.997	Q28889 →
P43481	—	0.997	P43481 →
EPHA6	Ephrin type-A receptor 6	0.996	landscape →
Q2HWD6	—	0.996	Q2HWD6 →
Q76II0	—	0.996	Q76II0 →
Q28317	—	0.996	Q28317 →
Q08156	—	0.995	Q08156 →
Q60629	—	0.995	Q60629 →
Q07407	—	0.995	Q07407 →
Q07498	—	0.995	Q07498 →
P79750	—	0.995	P79750 →
P05532	—	0.994	P05532 →
Q26614	—	0.994	Q26614 →
P26619	—	0.994	P26619 →
Q62413	—	0.994	Q62413 →
Q9I8N6	—	0.994	Q9I8N6 →
Q91909	—	0.994	Q91909 →
EPHA5	Ephrin type-A receptor 5	0.994	landscape →
Q8AXC7	—	0.994	Q8AXC7 →
P54755	—	0.993	P54755 →
P52583	—	0.993	P52583 →
P09581	—	0.993	P09581 →
P54757	—	0.993	P54757 →
Q09147	—	0.993	Q09147 →