NCAPH — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

	Compound	Confidence	Supporting neighbours

Clinical trials — most relevant to NCAPH by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Cornelia De Lange Syndrome: Assessing Positive Effects of Lithium Treatment	PHASE2/PHASE3	RECRUITING
Compared the Efficacy and Safety of CDOP Combined With Chidamide and CDOP in de Novo Peripheral T Cell Lymphoma Patients	PHASE3	UNKNOWN
PhII 5-Azacytidine Plus Valproic Acid and Eventually Atra in Intermediate II and High Risk MDS	PHASE2	COMPLETED
Phase 1/ Phase 2 Study to Assess Safety and Efficacy of Orally Administered JBI-802 in Subjects With Myeloproliferative Neoplasms (MPN) and Myelodysplastic/Myeloproliferative Neoplasms (MDS/MPN) With Thrombocytosis	PHASE1/PHASE2	RECRUITING
Efficacy and Safety Assessment of Oral LBH589 in Adult Patients With Advanced Soft TIssue Sarcoma After Pre-treatment Failure	PHASE2	COMPLETED
LBH589 Treatment for Refractory Clear Cell Renal Carcinoma	PHASE2	COMPLETED
Trial of the Histone-Deacetylase Inhibitor ITF2357 Followed by Mechlorethamine in Relapsed/Refractory Hodgkin's Lymphoma	PHASE1/PHASE2	COMPLETED
Phase I Dose Finding and Proof-of-concept Study of Panobinostat With Standard Dose Cytarabine and Daunorubicin for Untreated Acute Myeloid Leukemia or Advanced Myelodysplastic Syndrome	PHASE1	COMPLETED
Phase I Study to Assess the Safety, Pharmacokinetics, & Pharmacodynamics of GSK923295 in Subjects w/ Refractory Cancer	PHASE1	COMPLETED
Investigations Into ISCU Myopathy or Iron Sulfur Scaffold U Protein Myopathy	nan	COMPLETED
Role of the Nuclear Pore Component RANBP2 in Inflammatory Responses to Viral Infections	nan	COMPLETED
Classification, Functional Stratification and Biomarkers in Ciliopathy (CILLICORIRCM)	nan	COMPLETED
Clinical and Genetic Analysis in Congenital Hypothyroidism Due to Thyroid Dysgenesis.	nan	COMPLETED
Genetic Analysis of Heart Channelopathies in Brazilian Patients and Their Relatives	nan	UNKNOWN
North Carolina Genomic Evaluation by Next-generation Exome Sequencing, 2	nan	COMPLETED
Chromosome 18 Clinical Research Center	nan	RECRUITING
Diagnosis of RSTS: Identification of the Acetylation Profiles as Epigenetic Markers for Assessing Causality of CREBBP and EP300 Variants.	nan	UNKNOWN
Genetic Bases of Neuroendocrine Neoplasms in Mexican Patients	nan	RECRUITING
Autophagy in Systemic Lupus Erythematosus	nan	UNKNOWN
Investigation of the Genetic Causes of Kallmann Syndrome and Reproductive Disorders	nan	COMPLETED
Positional Cloning of the Gene(s) Responsible for Alagille Syndrome	nan	COMPLETED
Effect of Adenovirus E1A Oncogene on DNA Replication Dynamics	nan	UNKNOWN
The Contribution of Optical Mapping to the Characterization of Chromosomal Rearrangements in Patients With Neurodevelopmental Disorders	nan	RECRUITING
Multi-Dimensional Genomic Dissection of Ring Chromosome 14 Syndrome	nan	ACTIVE_NOT_RECRUITING
Human Epilepsy Genetics--Neuronal Migration Disorders Study	nan	RECRUITING
Study of Synapsis and Recombination in Male Meiosis and the Implications in Infertility	nan	COMPLETED
PCD New Gene Discovery	nan	COMPLETED
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA	nan	RECRUITING
Advancing Neurogenetic Diagnoses Through Long-Read Sequencing	nan	NOT_YET_RECRUITING
Phenotypic and Genotypic Studies in Congenital and Early Onset Ataxias	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a NCAPH binder may also engage these)

Protein	Name	Similarity
O13067	—	0.998	O13067 →
Q8C156	—	0.998	Q8C156 →
Q564K3	—	0.995	Q564K3 →
Q641G4	—	0.990	Q641G4 →
Q4V8I2	—	0.987	Q4V8I2 →
Q8BSP2	—	0.987	Q8BSP2 →
Q28GV1	—	0.987	Q28GV1 →
Q3SZL8	—	0.981	Q3SZL8 →
Q6IBW4	—	0.980	Q6IBW4 →
Q9LUR0	—	0.979	Q9LUR0 →
Q5RH01	—	0.977	Q5RH01 →
D2HSB3	—	0.976	D2HSB3 →
Q9H4I0	—	0.973	Q9H4I0 →
D3ZND0	—	0.973	D3ZND0 →
P14629	—	0.972	P14629 →
Q9CYA6	—	0.972	Q9CYA6 →
Q5ZIM6	—	0.972	Q5ZIM6 →
Q9D479	—	0.972	Q9D479 →
G3X992	—	0.971	G3X992 →
Q6AYJ4	—	0.971	Q6AYJ4 →
Q9Y7R3	—	0.970	Q9Y7R3 →
Q8VDP4	—	0.970	Q8VDP4 →
F4HRV8	—	0.970	F4HRV8 →
Q9JJT9	—	0.970	Q9JJT9 →
Q92558	—	0.970	Q92558 →
Q8C5S7	—	0.970	Q8C5S7 →
Q68EF0	—	0.970	Q68EF0 →
Q7ZYB4	—	0.970	Q7ZYB4 →
Q5NVG8	—	0.970	Q5NVG8 →
Q3UQU0	—	0.970	Q3UQU0 →