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Sugi Predict / Targets / NCF1

NCF1

Neutrophil cytosol factor 1 · P14598 · NCF1 on Sugi Atlas →

38,575 patent compounds predicted against NCF1, 21,897 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL323374 SCHEMBL323374 0.64 10/20
SCHEMBL222345 SCHEMBL222345 0.50 10/20
SCHEMBL425929 SCHEMBL425929 0.52 8/20
SCHEMBL265139 SCHEMBL265139 0.61 7/20
SCHEMBL96224 SCHEMBL96224 0.51 7/20
SCHEMBL96005 SCHEMBL96005 0.49 7/20
SCHEMBL94707 SCHEMBL94707 0.46 7/20
SCHEMBL96151 SCHEMBL96151 0.44 7/20
SCHEMBL179520 SCHEMBL179520 0.53 6/20
SCHEMBL423902 SCHEMBL423902 0.52 6/20
SCHEMBL88762 SCHEMBL88762 0.52 6/20
SCHEMBL9312 SCHEMBL9312 0.53 5/20
SCHEMBL310511 SCHEMBL310511 0.43 5/20
SCHEMBL361523 SCHEMBL361523 1.00 4/20
SCHEMBL405110 SCHEMBL405110 0.47 4/20
SCHEMBL90018 SCHEMBL90018 0.46 4/20
SCHEMBL213419 SCHEMBL213419 0.42 4/20
SCHEMBL124426 SCHEMBL124426 0.39 4/20
SCHEMBL152779 SCHEMBL152779 0.34 4/20
SCHEMBL38775 SCHEMBL38775 1.00 3/20

Clinical trials — most relevant to NCF1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Colchicine for Symptom and Inflammation in Knee Osteoarthritis PHASE2/PHASE3COMPLETED
Fever and Neutropenia in Pediatric Oncology Patients PHASE3WITHDRAWN
A Study of the Safety and Efficacy of Prime Editing (PM359) in Participants With p47phox Autosomal Recessive Chronic Granulomatous Disease (CGD ) PHASE1/PHASE2ENROLLING_BY_INVITATION
A Phase I Study of Mozobil in the Treatment of Patients With WHIMS PHASE1/PHASE2RECRUITING
Efficacy of SALI-10 Oral Probiotics in Experimental Gingivitis PHASE2RECRUITING
Safety of hLF1-11 for the Treatment of Infectious Complications Among HSCT Recipients PHASE1/PHASE2WITHDRAWN
Aerosol Combination Therapy of All-trans Retinoic Acid and Isotretinoin as A Novel Treatment for Inducing Neutralizing Antibodies in COVID -19 Infected Patients Better Than Vaccine : An Innovative Treatment PHASE2UNKNOWN
Allogeneic Hematopoietic Stem Cell Transplant for Patients With Inborn Errors of Immunity PHASE2RECRUITING
A Pilot Study of Azithromycin Prophylaxis for Acute Chest Syndrome in Sickle Cell Disease PHASE1WITHDRAWN
Effect of IFN-γ on Innate Immune Cells PHASE1COMPLETED
NCF Gene & TNFSF4 in SLE Patients nanUNKNOWN
Lentiviral Gene Therapy for CGD nanRECRUITING
Neutrophils as Prognostic Factors in Granulomatosis With Polyangiitis (Formerly Named Wegener's Granulomatosis) nanCOMPLETED
Prevalence of Antibodies and Cytokines in Participants With Chronic Granulomatous Disease nanRECRUITING
Immunological Profile and Clinical Characteristics of Children Diagnosed With Chronic Granulomatous Disease nanUNKNOWN
S100A8 in Serum and Urine as a New Biomarker in Lupus Nephritis nanCOMPLETED
Infant Immune Response to Bacterial Infection nanCOMPLETED
The Epigenomic Signature of Eosinophilic Granulomatosis With Polyangiitis nanUNKNOWN
Role of Genetics in Idiopathic Pulmonary Fibrosis (IPF) nanUNKNOWN
Lung Mucus Hypersecretion and NQO1 nanCOMPLETED
Study of the Functional Status Neutrophils in Rheumatoid Arthritis Patients to Identify New Biomarkers of Response to Anti-TNFalpha Therapy nanUNKNOWN
Efficacy of Granulocyte-Colony Stimulating Factor (G-CSF) nanUNKNOWN
Role of ADA SNPs in Subjects With Relapsing Multiple Sclerosis (RMS) nanUNKNOWN
Ccf mtDNA as a Neurodegenerative Biomarker nanUNKNOWN
Ankylosing Spondylitis nanNOT_YET_RECRUITING
Neutrophil Extracellular Trap Formation in Patients Undergoing Bone Marrow Transplant nanCOMPLETED
Patients Treated for Chronic Granulomatous Disease (CGD) Since 1995 nanUNKNOWN
Thermogenic Silencer Regulatory Factors in Humans nanACTIVE_NOT_RECRUITING
Aminophylline to Prevent Acute Kidney Injury in Children After Cardiac Surgery nanCOMPLETED
Effect Inhaled Nitric Oxide in Adult Liver Transplant nanNOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a NCF1 binder may also engage these)

ProteinNameSimilarity
A8MVU1 — 1.000 A8MVU1 →
F1M707 — 0.993 F1M707 →
O77774 — 0.993 O77774 →
A6NI72 — 0.992 A6NI72 →
Q09014 — 0.988 Q09014 →
Q5RDS2 — 0.973 Q5RDS2 →
Q32LP7 — 0.970 Q32LP7 →
O75563 — 0.969 O75563 →
MAP3K20 Mitogen-activated protein kinase kinase kinase 20 0.968 landscape →
Q3LAC4 — 0.967 Q3LAC4 →
PRKD1 Serine/threonine-protein kinase D1 0.966 landscape →
Q9WVQ1 — 0.966 Q9WVQ1 →
Q80U40 — 0.964 Q80U40 →
A7MBL8 — 0.964 A7MBL8 →
Q3UND0 — 0.964 Q3UND0 →
P00535 — 0.963 P00535 →
Q9Z1T4 — 0.963 Q9Z1T4 →
Q9ESL4 — 0.963 Q9ESL4 →
Q86UL8 — 0.962 Q86UL8 →
Q920G0 — 0.962 Q920G0 →
Q9WTQ1 — 0.961 Q9WTQ1 →
Q62101 — 0.961 Q62101 →
Q8K3H0 — 0.961 Q8K3H0 →
A1ZAY1 — 0.959 A1ZAY1 →
Q66H91 — 0.959 Q66H91 →
A6NI28 — 0.959 A6NI28 →
Q69ZK0 — 0.959 Q69ZK0 →
Q14161 — 0.959 Q14161 →
Q08D85 — 0.958 Q08D85 →
PRKD3 Serine/threonine-protein kinase D3 0.958 landscape →