Sugi Predict

Sugi Predict / Targets / NHERF1

NHERF1

Na(+)/H(+) exchange regulatory cofactor NHE-RF1 · O14745 · NHERF1 on Sugi Atlas →

4,765 patent compounds predicted against NHERF1, 3,324 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL1308355 SCHEMBL1308355 0.81 6/20
SCHEMBL1310023 SCHEMBL1310023 0.73 6/20
SCHEMBL846035 SCHEMBL846035 0.58 6/20
SCHEMBL592274 SCHEMBL592274 0.56 6/20
SCHEMBL1518680 SCHEMBL1518680 0.55 6/20
SCHEMBL3590666 SCHEMBL3590666 0.55 6/20
SCHEMBL1434913 SCHEMBL1434913 0.65 5/20
SCHEMBL3054198 SCHEMBL3054198 0.52 5/20
SCHEMBL4120568 SCHEMBL4120568 0.45 5/20
SCHEMBL914854 SCHEMBL914854 0.42 5/20
SCHEMBL1306446 SCHEMBL1306446 0.74 4/20
SCHEMBL2760002 SCHEMBL2760002 0.73 4/20
SCHEMBL398244 SCHEMBL398244 0.56 4/20
SCHEMBL3443344 SCHEMBL3443344 0.56 4/20
SCHEMBL3932676 SCHEMBL3932676 0.55 4/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL2900370) 0.55 4/20
SCHEMBL209351 SCHEMBL209351 0.54 4/20
SCHEMBL3058666 SCHEMBL3058666 0.52 4/20
SCHEMBL2967686 SCHEMBL2967686 0.47 4/20
SCHEMBL2759996 SCHEMBL2759996 0.75 3/20

Clinical trials — most relevant to NHERF1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
The RECONSTRUCT Study - Reconstructing Disease Mechanisms in Asthma PHASE4COMPLETED
Efficacy and Safety of Tigerase® vs. Pulmozyme® in Patients With Cystic Fibrosis PHASE3COMPLETED
Safety and Tolerability of Inhaled Nitric Oxide in Patients With Cystic Fibrosis PHASE1/PHASE2COMPLETED
A Phase I, Open-Labeled, Single-Arm, Dose Escalation, Clinical and Pharmacology Study of Dichloroacetate (DCA) in Patients With Recurrent and/or Metastatic Solid Tumours PHASE1COMPLETED
Proof of Principle Study for an Efficacy Trial of Linaclotide for Cystic Fibrosis EARLY_PHASE1RECRUITING
POTASSIUM-RICH SALT SUBSTITUTES IN KIDNEY TRANSPLANT RECIPIENTS nanNOT_YET_RECRUITING
Lithium Countertransport and Blood Pressure In CARDIA and TOMHS nanCOMPLETED
Sodium Transport: Genetics and Hypertension nanCOMPLETED
Phenotypic and Genotypic Studies in Congenital and Early Onset Ataxias nanCOMPLETED
The Energetic Origin of Neurodegeneration in MS nanCOMPLETED
How Secreted-embryo-derived Trypsin Initiates, Maintains and Terminates Ca2+ Signals in Uterine Epithelial Cells nanCOMPLETED
The Effect of High and Low Sodium Intake on Urinary Aquaporin-2 in Healthy Humans. nanCOMPLETED
Na+ Channel mRNA Regulation in Heart Failure nanCOMPLETED
Sodium Channel Splicing in Heart Failure Trial nanCOMPLETED
A Biomarker to Detect Salt Sensitivity nanCOMPLETED
Adverse Airway Effects From Tobacco and E-Cigarettes nanUNKNOWN
Cardiovascular Effects of Empagliflozine nanUNKNOWN
Genetic Architecture of Natriuretic Peptides and Blood Pressure Response nanNOT_YET_RECRUITING
Primary Nasal Cell Culture as a Tool for Personalized Therapy in Cystic Fibrosis nanCOMPLETED
Genetic Epidemiology of Blood Pressure Intervention nanCOMPLETED
Prevalence and Risk Factors of Nephrocalcinosis in Children at Sohag University Hospital nanUNKNOWN
Blood Pressure Control in Juveniles - Longitudinal Study nanCOMPLETED
Genetic and Environmental Determinants of Hypertension nanCOMPLETED
Sodium vs Potassium Education to Improve Vascular Health nanRECRUITING
Qatar Cardiovascular Biorepository of AF Patients nanUNKNOWN
Acute Effects of GLP-1 on Renal Hemodynamics nanCOMPLETED
The Effects of Isotonic and Hypertonic Saline Infusion on Renal Biomarkers in Healthy Young Subjects nanCOMPLETED
Effect of Hypertonic Sodium Chloride on Urinary Biomarkers in Healthy Subjects and Patients With Chronic Kidney Disease nanCOMPLETED
Skin Sodium and Salt Sensitivity of Blood Pressure nanUNKNOWN
Factors Affecting Salt Intake in Young Adults nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a NHERF1 binder may also engage these)

ProteinNameSimilarity
Q4R6G4 — 1.000 Q4R6G4 →
Q3SZK8 — 1.000 Q3SZK8 →
P70441 — 1.000 P70441 →
Q28619 — 0.999 Q28619 →
Q9JJ19 — 0.996 Q9JJ19 →
Q8SQG9 — 0.992 Q8SQG9 →
Q5ZM14 — 0.988 Q5ZM14 →
Q792I0 — 0.988 Q792I0 →
Q0P5F3 — 0.988 Q0P5F3 →
Q2KIB6 — 0.986 Q2KIB6 →
B1AK53 — 0.986 B1AK53 →
Q6RHR9 — 0.985 Q6RHR9 →
Q12756 — 0.985 Q12756 →
P47709 — 0.985 P47709 →
Q9QVP9 — 0.985 Q9QVP9 →
Q8BGT6 — 0.985 Q8BGT6 →
Q9Z1I6 — 0.985 Q9Z1I6 →
O93307 — 0.984 O93307 →
BRPF3 Bromodomain and PHD finger-containing protein 3 0.984 landscape →
P98150 — 0.984 P98150 →
Q9D1P2 — 0.984 Q9D1P2 →
P00520 — 0.984 P00520 →
Q9EQW7 — 0.984 Q9EQW7 →
Q15599 — 0.984 Q15599 →
P70271 — 0.983 P70271 →
Q61210 — 0.983 Q61210 →
Q99P99 — 0.983 Q99P99 →
Q9JHL1 — 0.983 Q9JHL1 →
Q5R8Z4 — 0.983 Q5R8Z4 →
Q6QMY5 — 0.983 Q6QMY5 →