NIBAN2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

	Compound	Confidence	Supporting neighbours

Clinical trials — most relevant to NIBAN2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Treatment With HMG-COA Reductase Inhibitor of Growth and Bone Abnormalities in Children With Noonan Syndrome	PHASE3	COMPLETED
Testing of NBIA Genes: Analysis of Genetic Heterogeneity and Validation of Mitochondrial Markers for Assessing Causality of Sequence Variants.	nan	COMPLETED
Identification of the Genetic Causes of Rare Diseases With Negative Exome Findings	nan	UNKNOWN
Feasibility of Improving Risk Stratification in Brugada Syndrome	nan	COMPLETED
The LD Lync Study - Natural History Study of Lipodystrophy Syndromes	nan	RECRUITING
Genetic Characterization of Parkinson's Disease	nan	COMPLETED
Artificial Intelligence for the Prioritization of Genetic Background in Brugada Syndrome	nan	COMPLETED
Biomarkers in SCOTland CardiomyopatHy Registry (Bio-SCOTCH)	nan	RECRUITING
Genetic Bases of Neuroendocrine Neoplasms in Mexican Patients	nan	RECRUITING
Characterization of New Candidate Genes in Cases of Human Inherited Thrombocytopenia (CATCH)	nan	COMPLETED
Whole-genome Sequencing Study in Patients With Diminished Ovarian Reserve	nan	UNKNOWN
Mayo AVC Registry and Biobank	nan	RECRUITING
Search for Phenotype-modifying Genes in Patients With Intellectual Disabilities.	nan	NOT_YET_RECRUITING
Gene Analysis of Parkinson's Disease	nan	COMPLETED
Thermogenic Silencer Regulatory Factors in Humans	nan	ACTIVE_NOT_RECRUITING
Effect of NOTCH2NLC Gene Variations on NIID Clinical Features	nan	RECRUITING
Identification and Characterization of Novel Non-Coding Variants That Contribute to Genetic Disorders	nan	COMPLETED
Study of a Candidate Gene Involved in Goldenhar Syndrome.	nan	COMPLETED
Heart and Skeletal Muscle Problems in Neuroacanthocytosis	nan	COMPLETED
North Carolina Genomic Evaluation by Next-generation Exome Sequencing, 2	nan	COMPLETED
Prevalence of a Non-Expressing 11B Mutation in Aka Peoples of the Central African Republic	nan	COMPLETED
Longitudinal Study of Neurogenetic Disorders	nan	RECRUITING
Universal Rare Gene Study: A Registry and Natural History Study of Retinal Dystrophies Associated With Rare Disease-Causing Genetic Variants	nan	RECRUITING
Hereditary Nonpolyposis Colorectal Cancer in Taiwan-Related Genetic Study and Clinical Applications	nan	UNKNOWN
Genetics of Neonatal Encephalopathy and Related Disorders	nan	RECRUITING
Advancing Neurogenetic Diagnoses Through Long-Read Sequencing	nan	NOT_YET_RECRUITING
Natural History Evaluation of Charcot Marie Tooth Disease (CMT) Types CMT1B, CMT2A, CMT4A, CMT4C, and Others	nan	RECRUITING
Whole Exome and Whole Genome Sequencing for Genotyping of Inherited and Congenital Eye Conditions	nan	RECRUITING
Phenotypic and Genotypic Characterization of Subjects With Syndromic Obesity: Identifying New Candidate Genes by Exome Sequencing (OBEXOME)	nan	COMPLETED
Mapping Novel Disease Genes for Dilated Cardiomyopathy	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a NIBAN2 binder may also engage these)

Protein	Name	Similarity
Q8R1F1	—	1.000	Q8R1F1 →
B4F7E8	—	1.000	B4F7E8 →
Q9Z1N9	—	0.986	Q9Z1N9 →
Q5FVG6	—	0.984	Q5FVG6 →
Q8BYR5	—	0.983	Q8BYR5 →
Q4KUS2	—	0.981	Q4KUS2 →
Q9TUG2	—	0.980	Q9TUG2 →
Q92622	—	0.979	Q92622 →
Q9UPT6	—	0.979	Q9UPT6 →
Q6F6B3	—	0.978	Q6F6B3 →
Q80U62	—	0.978	Q80U62 →
Q60698	—	0.978	Q60698 →
P85299	—	0.978	P85299 →
O15079	—	0.978	O15079 →
Q812A5	—	0.977	Q812A5 →
Q99LB0	—	0.977	Q99LB0 →
Q8AVJ1	—	0.977	Q8AVJ1 →
O54828	—	0.977	O54828 →
Q80U28	—	0.977	Q80U28 →
Q3UFQ8	—	0.977	Q3UFQ8 →
Q9NZQ3	—	0.977	Q9NZQ3 →
Q80TJ1	—	0.976	Q80TJ1 →
Q8C6B2	—	0.976	Q8C6B2 →
Q05AA6	—	0.976	Q05AA6 →
Q8K4S7	—	0.976	Q8K4S7 →
O60271	—	0.976	O60271 →
Q3UKU4	—	0.976	Q3UKU4 →
Q6EDY6	—	0.976	Q6EDY6 →
Q8R2V2	—	0.976	Q8R2V2 →
Q5FVC2	—	0.976	Q5FVC2 →