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Sugi Predict / Targets / NPR1

NPR1

Atrial natriuretic peptide receptor 1 · P16066 · NPR1 on Sugi Atlas →

1,699 patent compounds predicted against NPR1, 613 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL28726534 SCHEMBL28726534 0.58 20/20
SCHEMBL22745355 SCHEMBL22745355 0.57 20/20
SCHEMBL4349736 SCHEMBL4349736 0.56 19/20
SCHEMBL4367513 SCHEMBL4367513 0.55 18/20
SCHEMBL4349987 SCHEMBL4349987 0.54 18/20
SCHEMBL4177240 SCHEMBL4177240 0.52 17/20
SCHEMBL4363108 SCHEMBL4363108 0.51 16/20
SCHEMBL18041213 SCHEMBL18041213 0.54 15/20
SCHEMBL4360563 SCHEMBL4360563 0.48 11/20
SCHEMBL4184276 SCHEMBL4184276 0.44 10/20
SCHEMBL4353856 SCHEMBL4353856 0.47 9/20
SCHEMBL4359507 SCHEMBL4359507 0.47 9/20
SCHEMBL4367755 SCHEMBL4367755 0.46 9/20
SCHEMBL4358026 SCHEMBL4358026 0.48 8/20
SCHEMBL12715897 SCHEMBL12715897 0.39 8/20
SCHEMBL15161359 SCHEMBL15161359 0.44 7/20
SCHEMBL4166983 SCHEMBL4166983 0.45 6/20
SCHEMBL4188225 SCHEMBL4188225 0.44 6/20
SCHEMBL12715883 SCHEMBL12715883 0.36 6/20
SCHEMBL3133743 SCHEMBL3133743 0.54 5/20

Clinical trials — most relevant to NPR1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
A Study Of The Usage Of Statins In A Community Heart Failure Population PHASE4COMPLETED
Dose-comparison Study of Prednisone in Heart Failure PHASE3COMPLETED
The Effects of Sacubitril/Valsartan Compared to Valsartan on LV Remodelling in Asymptomatic LV Systolic Dysfunction After MI PHASE3COMPLETED
Survival Study of the Recombinant Human Neuregulin-1β in Subjects With Chronic Heart Failure. PHASE3UNKNOWN
Race, Natriuretic Peptides and Physiological Perturbations PHASE2COMPLETED
The Effects of Atorvastatin on the Nitric Oxide-system in Healthy Young Man PHASE2COMPLETED
Personalised Prospective Comparison of ARni With ArB in Patients With Natriuretic Peptide eLEvation PHASE2UNKNOWN
Effects of Chimeric Natriuretic Peptide Versus Placebo in Stable Heart Failure and Moderate Renal Dysfunction PHASE1WITHDRAWN
BNP Pharmacodynamics and Effects on Metabolism in Lean and Obese Subjects PHASE1COMPLETED
Effects of Different Forms of a Natural Heart Hormone on Blood Pressure and Fluid Balance in Healthy Volunteers EARLY_PHASE1COMPLETED
C-Type Natriuretic Peptide and Achondroplasia nanCOMPLETED
Ankle Brachial Index Versus Conventional Cardiac Risk Indices nanUNKNOWN
Relationship of Brain Natriuretic Peptide (BNP) Levels to Cardiac Diagnosis, Operation Performed, Post-operative Course and Outcome nanCOMPLETED
Diagnostic and Prognostic Role of Troponin and Brain Natriuretic Peptide in Pediatric Patients With Cardiomyopathy in Correlation to Echocardiography Findings nanUNKNOWN
B-type Natriuretic Peptide as a Surrogate Marker Guiding Post-operative Fluid Off-loading nanCOMPLETED
A Biomarker to Detect Salt Sensitivity nanCOMPLETED
Effects of Nesiritide in Pediatric Patients With Heart Failure nanWITHDRAWN
Neurological Prognostication of Patients in Therapeutic Hypothermia After Cardiac Arrest nanCOMPLETED
The Natriuretic Peptide System in African-Americans. nanCOMPLETED
ARgentinean Risk Assessment Registry in ACS; the ARRA-RACS Study nanCOMPLETED
Qatar Cardiovascular Biorepository of AF Patients nanUNKNOWN
Pharmacogenomics in Pulmonary Arterial Hypertension nanWITHDRAWN
A Cut-off Value Study of N-terminal Brain Natriuretic Peptide （Chemiluminescence Method） nanCOMPLETED
Comparison of BNP and NT-proBNP in the Management of Patients With Chronic and Acute Heart Failure nanUNKNOWN
Analysis of Cardiac Biomarker Racial Discrepancies nanENROLLING_BY_INVITATION
ULtrafiltration-Rate Induced CArdiac Strain (ULRICA) - Study nanRECRUITING
GENESIS: Genotype Guided - Natriuretic Peptides - Cardiometabolic Health Study nanRECRUITING
Correlational Study on the Biomarkers Application to the Prediction and Diagnosis of Cardiovascular Diseases nanCOMPLETED
Impact of Clinical, Demographic and Laboratory Variables on Brain Natriuretic Peptide Levels nanWITHDRAWN
The Diurnal Rhythm in Natriuretic Peptide Levels nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a NPR1 binder may also engage these)

ProteinNameSimilarity
P18293 — 1.000 P18293 →
P18910 — 1.000 P18910 →
P16067 — 0.999 P16067 →
Q6VVW5 — 0.999 Q6VVW5 →
P20594 — 0.996 P20594 →
P46197 — 0.992 P46197 →
P55203 — 0.983 P55203 →
P51840 — 0.983 P51840 →
P51839 — 0.982 P51839 →
P52785 — 0.980 P52785 →
O19179 — 0.980 O19179 →
Q02846 — 0.975 Q02846 →
A0A0U1RPR8 — 0.974 A0A0U1RPR8 →
O02740 — 0.973 O02740 →
GRM2 Metabotropic glutamate receptor 2 0.972 landscape →
EPHB4 Ephrin type-B receptor 4 0.972 landscape →
P55202 — 0.970 P55202 →
Q14BI2 — 0.970 Q14BI2 →
A0JPA0 — 0.970 A0JPA0 →
P00542 — 0.969 P00542 →
P31421 — 0.969 P31421 →
Q5RAN0 — 0.969 Q5RAN0 →
P80203 — 0.968 P80203 →
Q61526 — 0.968 Q61526 →
PLCD1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 0.968 landscape →
Q5U3W1 — 0.968 Q5U3W1 →
P70218 — 0.968 P70218 →
P47823 — 0.968 P47823 →
Q5R9N3 — 0.968 Q5R9N3 →
Q61288 — 0.968 Q61288 →