NUDT1

Oxidized purine nucleoside triphosphate hydrolase · P36639 · NUDT1 on Sugi Atlas →

43,360 patent compounds predicted against NUDT1, 20,515 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL100370 SCHEMBL100370 0.46 8/20
SCHEMBL264853 SCHEMBL264853 0.49 7/20
SCHEMBL100468 SCHEMBL100468 0.46 7/20
SCHEMBL100939 SCHEMBL100939 0.46 7/20
SCHEMBL98273 SCHEMBL98273 0.44 7/20
SCHEMBL98619 SCHEMBL98619 0.43 7/20
SCHEMBL45713 SCHEMBL45713 0.56 6/20
SCHEMBL218367 SCHEMBL218367 0.51 6/20
SCHEMBL250475 SCHEMBL250475 0.51 6/20
SCHEMBL101422 SCHEMBL101422 0.48 6/20
SCHEMBL306661 SCHEMBL306661 0.47 6/20
SCHEMBL397466 SCHEMBL397466 0.47 6/20
SCHEMBL414100 SCHEMBL414100 0.47 6/20
SCHEMBL99235 SCHEMBL99235 0.42 6/20
SCHEMBL99352 SCHEMBL99352 0.42 6/20
SCHEMBL100067 SCHEMBL100067 0.41 6/20
SCHEMBL100052 SCHEMBL100052 0.40 6/20
SCHEMBL215756 SCHEMBL215756 0.70 5/20
SCHEMBL29154 SCHEMBL29154 0.69 5/20
SCHEMBL102315 SCHEMBL102315 0.57 5/20

Clinical trials — most relevant to NUDT1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Acelarin First Line Randomised Pancreatic Study PHASE2/PHASE3SUSPENDED
Evaluation of Compliance With Treatment by Genvoya in HIV Post-exposure Prophylaxis PHASE3COMPLETED
A RCT of TNF and ENT in the Treatment of Long-term Prognosis With Hepatitis B-related HCC After Curative Resection PHASE3UNKNOWN
Targeting de Novo Pyrimidine Biosynthesis by Leflunomide for the Treatment of COVID-19 Virus Disease PHASE3COMPLETED
Clofarabine and Cytarabine in Treating Young Patients With Refractory or Relapsed Acute Myeloid Leukemia or Acute Lymphoblastic Leukemia PHASE1/PHASE2COMPLETED
University of California, San Diego (UCSD) Suramin Autism Treatment-1 (SAT1) Trial PHASE1/PHASE2COMPLETED
A Study Comparing CO-1.01 With Gemcitabine as First Line Therapy in Patients With Metastatic Pancreatic Adenocarcinoma (LEAP) PHASE2COMPLETED
Phase II Study of Ribose, Uridine, and Thymidine for a Complex Syndrome Involving Excessive 5'-Nucleotidase Activity PHASE2COMPLETED
Effects of Uridine Supplementation on Metabolic Side Effects of Stavudine and Zidovudine PHASE2COMPLETED
Study of Cytolytic Viral Activation Therapy (CVAT) for Recurrent/Metastatic Nasopharyngeal Carcinoma PHASE1UNKNOWN
Nucleoside Therapy in Patients With Telomere Biology Disorders PHASE1RECRUITING
A Randomized Controlled Trial of Topical 5% Niacinamide for Skin Cancer Prevention in Transplant Recipients EARLY_PHASE1RECRUITING
Functional Pharmacogenomics of Childhood Acute Lymphoblastic Leukemia in Taiwan nanUNKNOWN
Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With Nicotinamide Riboside nanUNKNOWN
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation nanCOMPLETED
Effect of Polymorphisms in the Adenosine a2a Receptor Gene and AMPD2 Gene on Adenosine-Induced Vasodilation and Reactive Hyperemia nanCOMPLETED
A Study of the Interaction Between Tumor Susceptibility Gene Glycine N-methyltransferase (GNMT) and Lung Cancer nanUNKNOWN
Investigate eNAMPT in Multiple Myeloma Biology and Establish Its Role in Disease Progression nanCOMPLETED
DNA Adductomics for Colorectal Cancer Investigation nanUNKNOWN
Dietary Interventions Evaluating Transport of Uric Acid Across the Tubules nanCOMPLETED
Determination of the Effectiveness of Oral Chlorine Dioxide in the Treatment of COVID 19 nanUNKNOWN
Mechanistic Studies of Teriflunomide in RRMS nanCOMPLETED
A Natural History Study Seeks to Understand the Clinical, Genomic, Pharmacological, Laboratory, and Dietary Determinates of Pyrimidine and Purine Metabolism Disorders nanRECRUITING
In Vivo Assessment of Histamine Pharmacodynamics nanWITHDRAWN
Observational Study Evaluating the Prevalence of Enzyme Deficiency in Pulmonology Clinics (ADA) nanUNKNOWN
Pre-genotype NUDT 15 R139C on Reducing Thiopurine-induced Leucopenia in Inflammatory Bowel Disease nanUNKNOWN
Predicting Response to Capecitabine in Women With Metastatic Breast Cancer nanCOMPLETED
Role and Interactions of Adenosine, Receptors, Methionine Cycle Nutritional, Metabolic and Genetic Determinants in the Onset of Atrial Fibrillation in Normal Heart nanUNKNOWN
Prevalence of Adenosine Deaminase (ADA) Enzyme Deficiency Disease in Adult Patients With Pulmonary Alveolar Proteinosis nanUNKNOWN
Epidemiology of Gout in French Polynesia nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a NUDT1 binder may also engage these)

ProteinNameSimilarity
Q7ZWC3 0.998 Q7ZWC3 →
F1P963 0.995 F1P963 →
P53369 0.994 P53369 →
P53368 0.994 P53368 →
P95781 0.976 P95781 →
B5XNX5 0.976 B5XNX5 →
P56380 0.975 P56380 →
B4TPH8 0.975 B4TPH8 →
Q0T2N2 0.975 Q0T2N2 →
A7ZP69 0.975 A7ZP69 →
B7NN72 0.975 B7NN72 →
P59659 0.974 P59659 →
P41354 0.974 P41354 →
B7N5L6 0.974 B7N5L6 →
B7MXT2 0.974 B7MXT2 →
B5BCQ0 0.974 B5BCQ0 →
Q5PC77 0.974 Q5PC77 →
Q8Z544 0.974 Q8Z544 →
B6I7J4 0.974 B6I7J4 →
B7M5T3 0.974 B7M5T3 →
Q83KB9 0.974 Q83KB9 →
P44932 0.973 P44932 →
B7LM80 0.973 B7LM80 →
A4WDK7 0.973 A4WDK7 →
A9N5B7 0.973 A9N5B7 →
A1ADA3 0.973 A1ADA3 →
B7MG18 0.973 B7MG18 →
B4SYW7 0.972 B4SYW7 →
Q5LWT6 0.972 Q5LWT6 →
Q8FFM5 0.972 Q8FFM5 →