OGDH

2-oxoglutarate dehydrogenase complex component E1 · Q02218 · OGDH on Sugi Atlas →

0 patent compounds predicted against OGDH, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours

Clinical trials — most relevant to OGDH by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Glutamate for Metabolic Intervention in Coronary Surgery PHASE3COMPLETED
Nivolumab in Patients With IDH-Mutant Gliomas With and Without Hypermutator Phenotype PHASE2ACTIVE_NOT_RECRUITING
Studying the Biology of IDH-mutant Gliomas Via Longitudinal Observation of 2-hydroxyglutarate (2-HG) Using MR Spectroscopy PHASE2SUSPENDED
IDH2 (AG 221) Inhibitor in Patients With IDH2 Mutated Myelodysplastic Syndrome PHASE2ACTIVE_NOT_RECRUITING
Single Agent Regorafenib in First-line for Metastatic/Unresectable KIT/PDGFR Wild Type GIST PHASE2COMPLETED
Effect of Deferoxamine on Wound Healing Rate in Patients With Diabetes Foot Ulcers PHASE2NOT_YET_RECRUITING
IDH1 (AG 120) Inhibitor in Patients With IDH1 Mutated Myelodysplastic Syndrome PHASE2ACTIVE_NOT_RECRUITING
Acetylcarnitine and Insulin Sensitivity PHASE2COMPLETED
Hydroxyproline Influence on Oxalate Metabolism PHASE1/PHASE2COMPLETED
First-line Irinotecan, Lederfolin and 5FU (FOLFIRI) and Bevacizumab in Patients With Advanced Colorectal Cancer PHASE2COMPLETED
Efficacy and Safety of the Treatment of Pyruvate Dehydrogenase Deficiency Patients With Glycerol Phenylbutyrate (RAVICTI) PHASE2RECRUITING
Eltrombopag as a Novel Therapeutic Approach for Low-risk MDS and CMML With TET2 Mutations PHASE2SUSPENDED
Erythropoietin Therapy for Subarachnoid Hemorrhage PHASE2COMPLETED
Therapeutic Efficacy of L-Ornithine L-Aspartate Infusion in Patients With Acute Liver Failure PHASE2UNKNOWN
Testing the Addition of an Anticancer Drug, Olaparib, to the Usual Chemotherapy (Temozolomide) for Advanced Neuroendocrine Cancer PHASE2ACTIVE_NOT_RECRUITING
Screening of IDH1 and IDH2 Gene Mutations in Adult Acute Myeloid Leukemia for Possible Targeted Therapy nanUNKNOWN
Prevalence and Clinical Effect of IDH1/2 Mutations in Patients With Acute Myeloid Leukemia nanUNKNOWN
Vorasidenib Guided by AGX PET in Recurrent/Low-grade Glioma nanNOT_YET_RECRUITING
Mitochondrial Function of Immune Cells in Sepsis nanCOMPLETED
Clinical Development of Cancer-Specific MRS Biomarkers in Malignant Gliomas nanCOMPLETED
Glycine and Magnesium+Thiamine for the Treatment of Primary Ciliary Dyskinesia nanRECRUITING
Expression of TET1 Gene in Acute Leukaemia nanUNKNOWN
Diagnostic and Therapeutic Targets in Cartilaginous Tumours nanRECRUITING
Remote Ischemic Postconditioning Increases HIF-1α Plasma Levels and Improves Cardiac Markers After Cardiac Surgery nanCOMPLETED
Fatty Acid Oxidation Defects and Insulin Sensitivity nanCOMPLETED
IDH1/IDH2 Mutation Frequency in Acute Myeloblastic Patients nanUNKNOWN
Study of Protein Translocation in Patients With Beta-Oxidation Disorders nanCOMPLETED
Prognostic Value of (DHODH) Expression in (HGSOC): A Comparative Study Between Neoadjuvant and Adjuvant Chemotherapy Settings nanNOT_YET_RECRUITING
Development of a Predictive Model for the Risk of Metastatic Disease in PPGLs, a Retrospective Cohort Study nanNOT_YET_RECRUITING
Alpha-Ketoglutarate and Abdominal Aortic Aneurysm Progression and Rupture nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a OGDH binder may also engage these)

ProteinNameSimilarity
Q9ULD0 1.000 Q9ULD0 →
K9IVI1 1.000 K9IVI1 →
D3ZQD3 1.000 D3ZQD3 →
Q68EW0 1.000 Q68EW0 →
Q60597 1.000 Q60597 →
Q5RCB8 1.000 Q5RCB8 →
Q5XI78 1.000 Q5XI78 →
Q623T0 1.000 Q623T0 →
Q60HE2 1.000 Q60HE2 →
O61199 1.000 O61199 →
Q6P6Z8 1.000 Q6P6Z8 →
Q148N0 1.000 Q148N0 →
Q5R9L8 1.000 Q5R9L8 →
Q23629 0.998 Q23629 →
Q6P286 0.998 Q6P286 →
Q5PRA2 0.997 Q5PRA2 →
Q4KLP0 0.996 Q4KLP0 →
P0AFG3 0.995 P0AFG3 →
Q5R7H0 0.995 Q5R7H0 →
Q72PJ7 0.995 Q72PJ7 →
P0AFG4 0.995 P0AFG4 →
P45303 0.995 P45303 →
Q96HY7 0.995 Q96HY7 →
A2ATU0 0.994 A2ATU0 →
Q54JE4 0.994 Q54JE4 →
Q9VA02 0.994 Q9VA02 →
A7Z5J9 0.994 A7Z5J9 →
P23129 0.993 P23129 →
Q8F6S7 0.993 Q8F6S7 →
O74378 0.993 O74378 →