OSGEP — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

	Compound	Confidence	Supporting neighbours

Clinical trials — most relevant to OSGEP by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Preventing Acute Kidney Injury (AKI) in Pediatric Patients	PHASE3	UNKNOWN
NEO100 and High-Grade Meningioma	PHASE2	RECRUITING
Phase II Study of Simvastatin Plus Irinotecan, Fluorouracil, and Leucovorin(FOLFIRI) for Metastatic CRC	PHASE2	COMPLETED
Simvastatin + Cetuximab/Irinotecan in K-ras Mutant Colorectal Cancer (CRC)	PHASE2	COMPLETED
Vaccine Treatment for Advanced Non-Small Cell Lung Cancer	PHASE1/PHASE2	COMPLETED
Administration of Methionine in Patients With Pulmonary Alveolar Proteinosis by Mutation of the MARS Gene.	PHASE1/PHASE2	COMPLETED
Safety, Tolerability and Pharmacokinetics of Benfo-Oxythiamine (B-OT) in Healthy Volunteers	PHASE1	COMPLETED
Effect of Gemfibrozil on Serum Glycosylphosphatidylinositol (GPI) Phospholipase D and Triglycerides	PHASE1	COMPLETED
Impact Of Choline in Patients With NAFLD	nan	UNKNOWN
Impact of Mutations in Aminoacyl tRNA Synthetases on Protein Translation and Cellular Stress	nan	WITHDRAWN
Determination of the Effectiveness of Oral Chlorine Dioxide in the Treatment of COVID 19	nan	UNKNOWN
Evaluation of Blood and Cardiac Protein O-GlcNAcylation Levels in Cardiac Surgery in Children	nan	RECRUITING
Evaluation of Blood Protein O-GlcNAcylation Levels in Children	nan	RECRUITING
Investigation of the Genetic and Environmental Causes of Autism: a Multi-Center Study	nan	NOT_YET_RECRUITING
Association of SNPs in Long Intergenic Noncoding RNA 00511 (LINC00511) With Breast Cancer Among the Egyptian Population	nan	COMPLETED
Impact of Weight Loss on the Human Sperm Epitranscriptome	nan	ACTIVE_NOT_RECRUITING
Effect of Sulfur Amino Acid Depletion and Acetaminophen on Plasma Glutatione	nan	COMPLETED
miR-155 Expression in Episodic and Chronic Migraine	nan	UNKNOWN
Role and Interactions of Adenosine, Receptors, Methionine Cycle Nutritional, Metabolic and Genetic Determinants in the Onset of Atrial Fibrillation in Normal Heart	nan	UNKNOWN
Cell Free Circulating Nucleic Acids as New Tumor Diagnostics From Human Plasma Samples.	nan	UNKNOWN
Protein Synthesis in the Brain of Patients With Fragile X Syndrome	nan	COMPLETED
Expression of Altered Glycosyltransferases, Mucins, and RTKs in Human Ovarian and Endometrial Cancers	nan	UNKNOWN
MiRNA223 and HMGB1 as Apredictos for Drug Resistant Epilepsy	nan	UNKNOWN
GDF-15 as a Biomarker for Mitochondrial Disease	nan	COMPLETED
Observational Study Evaluating the Prevalence of Enzyme Deficiency in Pulmonology Clinics (ADA)	nan	UNKNOWN
Exome Sequencing for Atypical Femoral Fractures	nan	COMPLETED
Mitigating Mitochondrial RNA Release During Aging to Control Inflammation and Senescence	nan	NOT_YET_RECRUITING
The Value of circRNAs (hsa_circ_0004001) in Early Diagnosis of HCC	nan	UNKNOWN
Identification of a New Gene Involved in Hereditary Lipodystrophy	nan	COMPLETED
Role of SF3B1 Mutation in Assessment of Acute and Chronic Lymphatic Leukemia	nan	NOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a OSGEP binder may also engage these)

Protein	Name	Similarity
Q9WVS2	—	1.000	Q9WVS2 →
Q0VCI1	—	1.000	Q0VCI1 →
Q8BWU5	—	1.000	Q8BWU5 →
Q5RHZ6	—	0.997	Q5RHZ6 →
Q7SYR1	—	0.997	Q7SYR1 →
A7SXZ6	—	0.997	A7SXZ6 →
Q2GXN6	—	0.993	Q2GXN6 →
Q4I5V2	—	0.992	Q4I5V2 →
Q0TVK3	—	0.991	Q0TVK3 →
Q5AYR1	—	0.990	Q5AYR1 →
Q4WDE9	—	0.990	Q4WDE9 →
A1CM94	—	0.989	A1CM94 →
Q9VV41	—	0.988	Q9VV41 →
Q7S745	—	0.988	Q7S745 →
Q0W2P3	—	0.987	Q0W2P3 →
Q2U9B5	—	0.987	Q2U9B5 →
Q6CCZ5	—	0.987	Q6CCZ5 →
Q55GU1	—	0.986	Q55GU1 →
Q12WQ7	—	0.986	Q12WQ7 →
Q1E406	—	0.984	Q1E406 →
Q0CH39	—	0.984	Q0CH39 →
A3QBM3	—	0.983	A3QBM3 →
A3N1C4	—	0.982	A3N1C4 →
Q8DEG4	—	0.982	Q8DEG4 →
A1S3S8	—	0.982	A1S3S8 →
Q74RQ9	—	0.982	Q74RQ9 →
A4THT1	—	0.982	A4THT1 →
Q1CME2	—	0.982	Q1CME2 →
B7VIH2	—	0.982	B7VIH2 →
A8GJV1	—	0.981	A8GJV1 →