PC — patent landscape · Sugi Predict

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL13164863	1.00	7/20
SCHEMBL25817542	0.95	7/20
SCHEMBL16704661	0.91	7/20
SCHEMBL24486419	0.88	7/20
SCHEMBL25993944	0.88	7/20
SCHEMBL3244839	0.83	7/20
SCHEMBL13164838	0.83	7/20
SCHEMBL13164859	0.83	7/20
SCHEMBL14554340	0.83	7/20
SCHEMBL15450689	0.83	7/20
SCHEMBL28280706	0.83	7/20
SCHEMBL29785205	0.83	7/20
SCHEMBL15445080	0.81	7/20
SCHEMBL16704630	0.81	7/20
SCHEMBL16704685	0.81	7/20
SCHEMBL16705022	0.81	7/20
SCHEMBL25817589	0.81	7/20
SCHEMBL13184525	0.74	7/20
SCHEMBL14023088	0.74	7/20
SCHEMBL16704655	0.74	7/20

Clinical trials — most relevant to PC by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Mitochondrial Redox Modulation in Newly Diagnosed Type 2 Diabetes: A Randomized Controlled Trial Comparing Imeglimin vs. Metformin Monotherapy	PHASE4	NOT_YET_RECRUITING
Quantifying Hepatic Mitochondrial Fluxes in Humans	PHASE4	RECRUITING
Trial of Dichloroacetate in Pyruvate Dehydrogenase Complex Deficiency:	PHASE3	ACTIVE_NOT_RECRUITING
Clinical Evaluation of the Effect of Metformin in Sepsis	PHASE3	UNKNOWN
Phase III Randomized Study of Sodium Dichloroacetate in Children With Congenital Lactic Acidosis	PHASE3	COMPLETED
Acetylcarnitine and Insulin Sensitivity	PHASE2	COMPLETED
Efficacy and Safety of the Treatment of Pyruvate Dehydrogenase Deficiency Patients With Glycerol Phenylbutyrate (RAVICTI)	PHASE2	RECRUITING
Thiamine as an Adjunctive Therapy in Cardiac Surgery	PHASE2	COMPLETED
A Study of Bezafibrate in Mitochondrial Myopathy	PHASE2	COMPLETED
The Effect of Glucagon on Rates of Hepatic Mitochondrial Oxidation in Man Assessed by PINTA	PHASE1	COMPLETED
Imaging of Traumatic Brain Injury Metabolism Using Hyperpolarized Carbon-13 Pyruvate	EARLY_PHASE1	ENROLLING_BY_INVITATION
UTSW HP [13-C] Pyruvate Injection in HCM	nan	COMPLETED
Lifestyle Intervention in Preparation for Pregnancy (LIPP)	nan	COMPLETED
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation	nan	COMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
Hepatic Energy Fluxes in NASH and NAS Patients	nan	ACTIVE_NOT_RECRUITING
TBI Multimodal Monitoring Study	nan	UNKNOWN
McArdle Disease Treatment by Ketogenic Diet	nan	COMPLETED
Natural History and Advanced Genetic Study of Pyruvate Dehydrogenase Complex Deficiencies	nan	RECRUITING
Mitoquines in COPD	nan	UNKNOWN
Combined Intracerebral and Jugular Bulb Microdialysis	nan	COMPLETED
Energy Expenditure and Quality of Life in Epilepsy	nan	WITHDRAWN
Metabolic Remodeling in Pulmonary Arterial Hypertension (PAH)	nan	COMPLETED
11C-Acetate PET/CT Non-FDG-Avid Tumors	nan	UNKNOWN
Alternative Substrates in the Critically Ill Subject	nan	COMPLETED
Lactate Profile and Fat Oxidation During Exercise	nan	COMPLETED
Study of Metabolic Changes in the Transformation Malignant Precancerous Skin Lesions	nan	COMPLETED
Carnitine Supplementation in Type 2 Diabetic Patients	nan	COMPLETED
EAA Intake to Optimize Protein Anabolism in COPD	nan	COMPLETED
Effect of Acute Fructose Load in Human	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a PC binder may also engage these)

Protein	Name	Similarity
P52873	—	1.000	P52873 →
Q29RK2	—	1.000	Q29RK2 →
Q05920	—	1.000	Q05920 →
O17732	—	0.997	O17732 →
O93918	—	0.995	O93918 →
Q0CLK1	—	0.993	Q0CLK1 →
Q99798	—	0.990	Q99798 →
Q99KI0	—	0.989	Q99KI0 →
P32327	—	0.989	P32327 →
Q9HES8	—	0.989	Q9HES8 →
Q8X1T3	—	0.989	Q8X1T3 →
B0KRD9	—	0.989	B0KRD9 →
C3K1K7	—	0.988	C3K1K7 →
Q9HXK5	—	0.988	Q9HXK5 →
Q9UUE1	—	0.987	Q9UUE1 →
D5AUD5	—	0.987	D5AUD5 →
P20004	—	0.987	P20004 →
C1DE40	—	0.987	C1DE40 →
Q867C9	—	0.987	Q867C9 →
Q9KWU4	—	0.986	Q9KWU4 →
Q8YIJ3	—	0.986	Q8YIJ3 →
Q60HD9	—	0.985	Q60HD9 →
A4VNV6	—	0.985	A4VNV6 →
A1CLD7	—	0.985	A1CLD7 →
P29278	—	0.985	P29278 →
Q9LNC5	—	0.985	Q9LNC5 →
Q8DMP6	—	0.985	Q8DMP6 →
P11154	—	0.985	P11154 →
Q0IIG5	—	0.985	Q0IIG5 →
P47859	—	0.985	P47859 →