PDHB

Pyruvate dehydrogenase E1 component subunit beta, mitochondrial · P11177 · PDHB on Sugi Atlas →

0 patent compounds predicted against PDHB, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours

Clinical trials — most relevant to PDHB by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Prevention of Renal Complications of Diabetes With Thiamine PHASE4UNKNOWN
Motor Function Efficacy of Pharmacological Treatments Targeting Energy Metabolism, in Parkinson's Patients PHASE4UNKNOWN
Trial of Dichloroacetate in Pyruvate Dehydrogenase Complex Deficiency: PHASE3ACTIVE_NOT_RECRUITING
Glutamate for Metabolic Intervention in Coronary Surgery PHASE3COMPLETED
Thiamine as an Adjunctive Therapy in Cardiac Surgery PHASE2COMPLETED
Efficacy and Safety of the Treatment of Pyruvate Dehydrogenase Deficiency Patients With Glycerol Phenylbutyrate (RAVICTI) PHASE2RECRUITING
Acetylcarnitine and Insulin Sensitivity PHASE2COMPLETED
Use of Phenylbutyrate Therapy for Patients With Pyruvate Dehydrogenase Complex Deficiency. PHASE2COMPLETED
Thiamine as Adjunctive Therapy for Diabetic Ketoacidosis PHASE2COMPLETED
Magnetic Resonance Imaging (MRI) With Hyperpolarized Pyruvate (13C) as Diagnostic Tool in Advanced Prostate Cancer PHASE2SUSPENDED
Hyperpolarized 13C Pyruvate MRI Scan in Predicting Tumor Aggressiveness in Patients With Renal Tumors PHASE2ACTIVE_NOT_RECRUITING
Single Agent Regorafenib in First-line for Metastatic/Unresectable KIT/PDGFR Wild Type GIST PHASE2COMPLETED
Imaging of Traumatic Brain Injury Metabolism Using Hyperpolarized Carbon-13 Pyruvate EARLY_PHASE1ENROLLING_BY_INVITATION
Natural History Study of Pyruvate Dehydrogenase Deficiency nanUNKNOWN
Natural History and Advanced Genetic Study of Pyruvate Dehydrogenase Complex Deficiencies nanRECRUITING
UTSW HP [13-C] Pyruvate Injection in HCM nanCOMPLETED
Thiamine As An Adjuvant Therapy For Hyperlactatemia In Septic Shock Patients nanUNKNOWN
Carnitine Supplementation in Type 2 Diabetic Patients nanCOMPLETED
Combined Effect of Exercise Intensity With Nutritional Supplementation on Skeletal Muscle Function nanCOMPLETED
Metabolic Remodeling in Pulmonary Arterial Hypertension (PAH) nanCOMPLETED
Influence of WNT4 VEZT FSHB and SIRT1 SNPs in Endometriosis: a Case Control Study of the Sardinian Population nanUNKNOWN
Biologic Mechanisms for Pain Variation After Physical Activity in Osteoarthritis nanCOMPLETED
Acquired Pyruvate Kinase Deficiency In Clonal Myeloid Neoplasms nanCOMPLETED
Pyruvate Kinase Deficiency Natural History Study nanCOMPLETED
Role of LDH as a Predictor of Treatment Outcomes in Hepatocellular Carcinoma nanUNKNOWN
Oxaloacetate Supplementation for Emotional PMS nanCOMPLETED
Acute Effect of Fructose on Lipid Metabolism and Gender Differences nanCOMPLETED
Molecular Mechanisms of Exercise Benefits to Insulin Resistant People nanCOMPLETED
McArdle Disease Treatment by Ketogenic Diet nanCOMPLETED
Effectiveness and Impact on the Quality of Life of Ketogenic Diet in Pediatric Patients nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a PDHB binder may also engage these)

ProteinNameSimilarity
Q5RE79 1.000 Q5RE79 →
P49432 1.000 P49432 →
Q9D051 1.000 Q9D051 →
P11966 1.000 P11966 →
P26269 1.000 P26269 →
P52904 0.994 P52904 →
Q6Z1G7 0.993 Q6Z1G7 →
O44451 0.993 O44451 →
Q09171 0.991 Q09171 →
Q9SAV3 0.990 Q9SAV3 →
Q10G39 0.990 Q10G39 →
P21874 0.989 P21874 →
Q0J0H4 0.989 Q0J0H4 →
P32473 0.989 P32473 →
Q38799 0.989 Q38799 →
Q86HX0 0.987 Q86HX0 →
Q7K5K3 0.987 Q7K5K3 →
Q2QM55 0.987 Q2QM55 →
P51266 0.986 P51266 →
G0RYE0 0.986 G0RYE0 →
Q9LDY2 0.986 Q9LDY2 →
Q32RS0 0.986 Q32RS0 →
P21882 0.986 P21882 →
Q4UKQ7 0.985 Q4UKQ7 →
Q55FN7 0.984 Q55FN7 →
Q1RJX3 0.984 Q1RJX3 →
Q9C6Z3 0.984 Q9C6Z3 →
P35488 0.983 P35488 →
O34591 0.983 O34591 →
Q9I1M1 0.983 Q9I1M1 →