PGK1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL1291715	1.00	20/20
SCHEMBL1291718	1.00	20/20
SCHEMBL1291724	1.00	20/20
SCHEMBL1291728	1.00	20/20
SCHEMBL1291734	1.00	20/20
SCHEMBL1291736	1.00	20/20
SCHEMBL1291737	1.00	20/20
SCHEMBL1291741	1.00	20/20
SCHEMBL1291743	1.00	20/20
SCHEMBL1291744	1.00	20/20
SCHEMBL1291746	1.00	20/20
SCHEMBL1291748	1.00	20/20
SCHEMBL1291753	1.00	20/20
SCHEMBL1291754	1.00	20/20
SCHEMBL1291756	1.00	20/20
SCHEMBL1291757	1.00	20/20
SCHEMBL1291758	1.00	20/20
SCHEMBL1291761	1.00	20/20
SCHEMBL1291762	1.00	20/20
SCHEMBL1291763	1.00	20/20

Clinical trials — most relevant to PGK1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effect of a Basal/Pre-Meal Insulin Strategy (Detemir/Aspart) on Insulin Secretion and Action in Type 2 Diabetes	PHASE4	COMPLETED
The G Protein-Coupled Receptor Kinase Type 2 Inhibitor Paroxetine as Adjunctive Therapy to Improve Insulin Sensitivity in Patients With Type 2 Diabetes Mellitus	PHASE3	UNKNOWN
European Celecoxib Trial in Primary Breast Cancer	PHASE3	COMPLETED
HSV-tk + Valacyclovir Therapy in Combination With Brachytherapy for Recurrent Prostate Cancer	PHASE1/PHASE2	RECRUITING
Bempedoic Acid Therapy for Polycystic Kidney Disease	PHASE2	NOT_YET_RECRUITING
STAR Cape+BKM120 MBC With Brain Met	PHASE2	COMPLETED
Efficacy of Amlexanox vs. Placebo in Type 2 Diabetic Patients	PHASE2	COMPLETED
Ketohexokinase Inhibition in NAFLD	PHASE2	COMPLETED
Safety, Tolerability and Pharmacokinetics of Benfo-Oxythiamine (B-OT) in Healthy Volunteers	PHASE1	COMPLETED
Dried Fruit and Postprandial Glycemia Trial	nan	UNKNOWN
Effect of Acute Fructose Load in Human	nan	COMPLETED
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation	nan	COMPLETED
Regulation of Lymphocyte Anti-tumor Response in Metastatic Patients Treated With the mTOR Inhibitor Everolimus	nan	COMPLETED
Insulin Resistance in Relation to Hyperthyroidism and Hypothyroidism	nan	UNKNOWN
Pilot Trial of Sirolimus/MEC in High Risk Acute Myelogenous Leukemia (AML)	nan	COMPLETED
Unrelated Donor BMT for Treatment of Patients With PGK Deficiency	nan	COMPLETED
The Role of Sugars in Fat Accumulation in the Liver	nan	RECRUITING
McArdle Disease Treatment by Ketogenic Diet	nan	COMPLETED
Evaluation of Thymidine Kinase Activity in the Serum of Patients With Solid Tumors	nan	UNKNOWN
Fluorodeoxyglucose Positron Emission Tomography (FDG PET) Findings in Patients With Phenylketonuria Before and After KUVAN Therapy	nan	COMPLETED
Effects of Dual-Source Carbohydrate Intake and Liver Glycogen Repletion After Overnight Fasting.	nan	NOT_YET_RECRUITING
Biomarkers in Exhaled Breath Condensates in Acute Lung Injury: Early Detection and Outcome Predictors	nan	UNKNOWN
Role of the Liver in Glucose Homeostasis Using Metabolic Imaging	nan	COMPLETED
METabolic PROFILE of Hepatocarcinoma and Pancreatic Tumors	nan	RECRUITING
Implementing Preemptive Pharmacogenomic Testing for Colorectal Cancer Patients in a Community Oncology Clinic	nan	COMPLETED
Effects of Polyphenols Found in Pomegranate and Olives Food Supplements on Postprandial Blood Glucose in Vivo.	nan	COMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
Alternative Substrates in the Critically Ill Subject	nan	COMPLETED
Vulvodynia: Identification of Potential Relevant Biomarkers	nan	COMPLETED
Identification of a New Blood Biomarker for the Diagnosis and Prognosis of Liposarcomas	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a PGK1 binder may also engage these)

Protein	Name	Similarity
A5A6K4	—	1.000	A5A6K4 →
Q60HD8	—	1.000	Q60HD8 →
P00559	—	1.000	P00559 →
Q5NVB5	—	1.000	Q5NVB5 →
Q7SIB7	—	1.000	Q7SIB7 →
P50310	—	1.000	P50310 →
P16617	—	1.000	P16617 →
Q3T0P6	—	1.000	Q3T0P6 →
Q4R3K4	—	1.000	Q4R3K4 →
P29408	—	1.000	P29408 →
Q6RI85	—	1.000	Q6RI85 →
P09411	—	1.000	P09411 →
P41759	—	0.999	P41759 →
O60101	—	0.999	O60101 →
PGK2	Phosphoglycerate kinase 2 (EC 2.7.2.3) (Phosp	0.999	landscape →
P51903	—	0.998	P51903 →
Q8MIF7	—	0.998	Q8MIF7 →
Q7ZA46	—	0.997	Q7ZA46 →
P09041	—	0.997	P09041 →
P41756	—	0.996	P41756 →
P24590	—	0.996	P24590 →
C4LE53	—	0.996	C4LE53 →
A8A466	—	0.994	A8A466 →
P0A7A0	—	0.994	P0A7A0 →
Q32BY6	—	0.994	Q32BY6 →
Q9GPM4	—	0.994	Q9GPM4 →
Q3AVX6	—	0.994	Q3AVX6 →
A9L1M3	—	0.993	A9L1M3 →
P29405	—	0.993	P29405 →
Q5PJI6	—	0.993	Q5PJI6 →