POLR2A

DNA-directed RNA polymerase II subunit RPB1 · P24928 · POLR2A on Sugi Atlas →

0 patent compounds predicted against POLR2A, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours

Clinical trials — most relevant to POLR2A by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
PhII 5-Azacytidine Plus Valproic Acid and Eventually Atra in Intermediate II and High Risk MDS PHASE2COMPLETED
S0720: Adjuvant Therapy Based on Gene Expression in Stage IA and IB Non-Small Cell Lung Cancer PHASE2COMPLETED
Subtenon Autologous Platelet-Rich Plasma in Inherited and Degenerative Retinal Diseases PHASE1/PHASE2ACTIVE_NOT_RECRUITING
A Study of Bezafibrate in Mitochondrial Myopathy PHASE2COMPLETED
Phase I Dose Finding and Proof-of-concept Study of Panobinostat With Standard Dose Cytarabine and Daunorubicin for Untreated Acute Myeloid Leukemia or Advanced Myelodysplastic Syndrome PHASE1COMPLETED
GTI-2040 in Treating Patients With Relapsed, Refractory, or High-Risk Acute Leukemia, High-Grade Myelodysplastic Syndromes, or Refractory or Blastic Phase Chronic Myelogenous Leukemia PHASE1COMPLETED
Evaluation of the Safety and the Tolerability of a Combination of Two HIV Inducers in Patients With Undetectable Viral Load PHASE1COMPLETED
Identifying Genes and Mutations Underlying Retinitis Pigmentosa and Allied Diseases nanUNKNOWN
Spironolactone and XPB-1 Integrity in the TFIIH Complex nanENROLLING_BY_INVITATION
InsightRP2 Registry nanRECRUITING
S8814A Biomarkers in Predicting Outcome in Postmenopausal Women With Hormone Receptor-Positive, Node-Positive Breast Cancer Treated With Tamoxifen With or Without Cyclophosphamide, Doxorubicin, and Fluorouracil nanCOMPLETED
Chronic Cough and CANVAS (Cerebellar Ataxia With Neuropathy and Bilateral Vestibular Areflexia Syndrome) nanCOMPLETED
Recombinant Interferon Alfa-2b in Treating Patients With Melanoma nanCOMPLETED
DNA Damage & Repair Proteins In Patients With Atherosclerotic Coronary Artery Disease nanCOMPLETED
Study of Specimens From Young Patients With Neuroblastoma nanCOMPLETED
Endolymphatic Sac Tumors in a Population of Patients With Von Hippel-Lindau Disease:The Natural History and Pathobiology, and a Prospective Non-Randomized Clinical Trial of Hearing Preservation Surgery in Patients With Early Stage Endolymphatic Sac Tumors nanCOMPLETED
Effect of Adenovirus E1A Oncogene on DNA Replication Dynamics nanUNKNOWN
Biomarkers in Patients With Diffuse Large B-Cell Lymphoma Treated With Combination Chemotherapy With or Without Rituximab nanCOMPLETED
Identification and Characterization of Ovarian Cancer and Endometrial Cancer Specific Biomarkers in Vaginal Fluids nanWITHDRAWN
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes nanCOMPLETED
Epigenetic Testing for Breast Cancer Risk Stratification nanCOMPLETED
The Molecular Pathogenesis Study of Cataract nanUNKNOWN
Prospective Open Clinical and Genetic Study of Patients With Retinitis Pigmentosa nanCOMPLETED
DNA Methylation and Autoimmune Thyroid Diseases nanCOMPLETED
Plant Extracted Natural Compounds Impact on Stage IV Breast Cancer Survival Time and Remission. nanUNKNOWN
DNA Analysis of Tumor Tissue From Patients With Acute Myeloid Leukemia nanCOMPLETED
Changes in DNA After Radiation Therapy in Patients With Prostate Cancer nanCOMPLETED
A Proof of Concept Study for the DNA Repair Driven by the Mesenchymal Stem Cells in Critical COVID-19 Patients nanCOMPLETED
Gene Modifiers of Cystic Fibrosis Lung Disease nanACTIVE_NOT_RECRUITING
S9031-S9126-S9333-S9500-B Biomarker Expression in Patients With Acute Myeloid Leukemia nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a POLR2A binder may also engage these)

ProteinNameSimilarity
G3MZY8 1.000 G3MZY8 →
P11414 1.000 P11414 →
P08775 1.000 P08775 →
P35074 1.000 P35074 →
P04050 1.000 P04050 →
Q75A34 1.000 Q75A34 →
P35084 1.000 P35084 →
P36594 1.000 P36594 →
A5DCV3 1.000 A5DCV3 →
P04052 1.000 P04052 →
P16356 1.000 P16356 →
POLR1A DNA-directed RNA polymerase I subunit RPA1 0.996 landscape →
P10964 0.995 P10964 →
P41556 0.995 P41556 →
P91875 0.994 P91875 →
P17546 0.993 P17546 →
O35134 0.993 O35134 →
O54889 0.992 O54889 →
P17545 0.992 P17545 →
A4IF62 0.990 A4IF62 →
Q86H36 0.990 Q86H36 →
P15398 0.989 P15398 →
Q6BI69 0.989 Q6BI69 →
Q8SSC4 0.989 Q8SSC4 →
Q42877 0.988 Q42877 →
P04051 0.988 P04051 →
Q9SVY0 0.987 Q9SVY0 →
Q5ZL98 0.987 Q5ZL98 →
O14802 0.987 O14802 →
Q8FB83 0.987 Q8FB83 →