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Sugi Predict / Targets / PRKAB1

PRKAB1

5'-AMP-activated protein kinase subunit beta-1 · Q9Y478 · PRKAB1 on Sugi Atlas →

61,014 patent compounds predicted against PRKAB1, 36,433 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL518066 SCHEMBL518066 1.00 17/20
SCHEMBL518005 SCHEMBL518005 1.00 16/20
SCHEMBL518045 SCHEMBL518045 1.00 16/20
SCHEMBL518134 SCHEMBL518134 1.00 16/20
SCHEMBL518023 SCHEMBL518023 0.93 16/20
SCHEMBL517797 SCHEMBL517797 0.89 16/20
SCHEMBL517976 SCHEMBL517976 0.89 16/20
SCHEMBL518068 SCHEMBL518068 0.88 16/20
SCHEMBL517980 SCHEMBL517980 0.84 16/20
SCHEMBL517967 SCHEMBL517967 0.81 16/20
SCHEMBL518037 SCHEMBL518037 0.80 16/20
SCHEMBL518123 SCHEMBL518123 0.79 16/20
SCHEMBL492421 SCHEMBL492421 0.45 16/20
SCHEMBL517982 SCHEMBL517982 1.00 15/20
SCHEMBL517879 SCHEMBL517879 0.92 15/20
SCHEMBL518044 SCHEMBL518044 0.84 15/20
SCHEMBL518117 SCHEMBL518117 0.83 15/20
SCHEMBL517878 SCHEMBL517878 0.71 15/20
SCHEMBL518070 SCHEMBL518070 0.70 15/20
SCHEMBL518069 SCHEMBL518069 0.68 15/20

Clinical trials — most relevant to PRKAB1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Short-Term Metformin Use in Young, Healthy Adults: Impacts on Exercise Capacity PHASE4COMPLETED
Alpha Ketoglutarate Enhances Geroprotection In Surgery (AEGIS) PHASE4RECRUITING
Status of Growth Hormone/ Insulin-like Growth Factor-1 (GH/IGF-1) Axis and Growth Failure in Ataxia Telangiectasia (AT) PHASE4UNKNOWN
Metformin Induces a Dietary Restriction-like State in Human PHASE4UNKNOWN
Clinical Evaluation of the Effect of Metformin in Sepsis PHASE3UNKNOWN
Metformin and Simvastatin Use in Bladder Cancer PHASE2UNKNOWN
Metformin as a Novel Therapy for Autosomal Dominant Polycystic Kidney Disease PHASE2COMPLETED
Efficacy of Amlexanox vs. Placebo in Type 2 Diabetic Patients PHASE2COMPLETED
Effects of Roflumilast on Insulin and Blood Sugar Levels in Prediabetic Overweight and Obese Individuals PHASE1/PHASE2COMPLETED
Safety and Feasibility of Metformin for Sepsis Induced AKI PHASE2COMPLETED
Metformin Hydrochloride in Preventing Esophageal Cancer in Patients With Barrett Esophagus PHASE2COMPLETED
Metformin for Fibromyalgia Symptoms (INFORM Trial) PHASE2RECRUITING
The Phosphodiesterase 4 Inhibitor Roflumilast as an Adjunct to Antidepressants in Major Depressive Disorder Patients PHASE1/PHASE2WITHDRAWN
Study to Investigate the Effect of PBF-680 on Forced Expiratory Volume in 1 Second (FEV1) in Asthmatic Patients PHASE2COMPLETED
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma PHASE1COMPLETED
Metformin's Effect on Glucagon-induced Glucose Production and Protein Metabolism. PHASE1COMPLETED
Sirolimus and Gold Sodium Thiomalate in Treating Patients With Advanced Squamous Non-Small Cell Lung Cancer PHASE1WITHDRAWN
Pre-Surgical Trial of the Combination of Metformin and Atorvastatin in Newly Diagnosed Operable Breast Cancer EARLY_PHASE1COMPLETED
Effect of Age on Glucose and Lipid Metabolism nanCOMPLETED
Intravenous Terbutaline in Severe Status Asthmaticus nanUNKNOWN
Cardiac and Skeletal Muscle Energy Metabolism in Abnormal Growth Hormone States nanCOMPLETED
NASH AMPK Exercise Dosing (AMPED) Trial nanRECRUITING
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation nanCOMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes nanCOMPLETED
Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy Men nanRECRUITING
Influence of Intermittent Hypoxia on Glycemic Control nanCOMPLETED
Study of Menstrual Irregularities and Endometrial Pathology in Women Undergoing Bariatric Surgery nanCOMPLETED
Ischemia-reperfusion Exercise Study nanCOMPLETED
Skeletal Muscle Mitochondrial Abnormalities and the Metabolic Syndrome in PAH nanCOMPLETED
Muscle Wasting in Cancer (MWIC) nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a PRKAB1 binder may also engage these)

ProteinNameSimilarity
Q5BIS9 — 1.000 Q5BIS9 →
Q5R801 — 1.000 Q5R801 →
Q9R078 — 1.000 Q9R078 →
P80386 — 1.000 P80386 →
P80387 — 0.959 P80387 →
Q9ERG2 — 0.955 Q9ERG2 →
Q13033 — 0.951 Q13033 →
Q9ESB5 — 0.951 Q9ESB5 →
Q8WXI2 — 0.950 Q8WXI2 →
Q3KR37 — 0.950 Q3KR37 →
O70585 — 0.949 O70585 →
Q8N987 — 0.949 Q8N987 →
Q9UPW8 — 0.949 Q9UPW8 →
Q9D2N4 — 0.949 Q9D2N4 →
Q8BG18 — 0.948 Q8BG18 →
Q9R1D7 — 0.948 Q9R1D7 →
Q9Z1T4 — 0.948 Q9Z1T4 →
Q5R467 — 0.947 Q5R467 →
Q9NZI7 — 0.947 Q9NZI7 →
Q8VGC3 — 0.947 Q8VGC3 →
Q62768 — 0.947 Q62768 →
Q9Y4J8 — 0.947 Q9Y4J8 →
Q80YA9 — 0.946 Q80YA9 →
Q5SRX1 — 0.946 Q5SRX1 →
O60941 — 0.946 O60941 →
Q5T6S3 — 0.946 Q5T6S3 →
G3V7Q0 — 0.946 G3V7Q0 →
Q6PAL8 — 0.946 Q6PAL8 →
Q99L90 — 0.946 Q99L90 →
A5D7H2 — 0.945 A5D7H2 →