Sugi Predict

Sugi Predict / Targets / PRPS1

PRPS1

Ribose-phosphate pyrophosphokinase 1 · P60891 · PRPS1 on Sugi Atlas →

2,853 patent compounds predicted against PRPS1, 1,534 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL18663541 SCHEMBL18663541 0.69 20/20
SCHEMBL18663554 SCHEMBL18663554 0.69 20/20
SCHEMBL18663650 SCHEMBL18663650 0.69 20/20
SCHEMBL18663697 SCHEMBL18663697 0.69 20/20
SCHEMBL18663556 SCHEMBL18663556 0.68 20/20
SCHEMBL18663712 SCHEMBL18663712 0.67 20/20
SCHEMBL18663602 SCHEMBL18663602 0.66 20/20
SCHEMBL18663603 SCHEMBL18663603 0.66 20/20
SCHEMBL18663662 SCHEMBL18663662 0.65 20/20
SCHEMBL18663571 SCHEMBL18663571 0.64 20/20
SCHEMBL18663622 SCHEMBL18663622 0.64 20/20
SCHEMBL18301440 SCHEMBL18301440 0.63 20/20
SCHEMBL18663579 SCHEMBL18663579 0.60 20/20
SCHEMBL18663538 SCHEMBL18663538 0.56 20/20
SCHEMBL18663601 SCHEMBL18663601 0.54 20/20
SCHEMBL18663696 SCHEMBL18663696 0.54 20/20
SCHEMBL18663552 SCHEMBL18663552 0.54 20/20
SCHEMBL18663663 SCHEMBL18663663 0.65 18/20
SCHEMBL18663664 SCHEMBL18663664 0.65 18/20
SCHEMBL18663707 SCHEMBL18663707 0.61 18/20

Clinical trials — most relevant to PRPS1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Acelarin First Line Randomised Pancreatic Study PHASE2/PHASE3SUSPENDED
Effects of Vitamin B3 in Patients With Ataxia Telangiectasia PHASE2COMPLETED
Effects of Roflumilast on Insulin and Blood Sugar Levels in Prediabetic Overweight and Obese Individuals PHASE1/PHASE2COMPLETED
Docetaxel Versus Docetaxel Plus Cisplatin Versus Docetaxel Plus S-1 as Second-line Chemotherapy in Metastatic Gastric Cancer PHASE2UNKNOWN
Safety Study of ABT-888 Plus Topotecan Hydrochloride to Treat Patients With Solid Tumors and Lymphomas PHASE1COMPLETED
Safety, Tolerability and Pharmacokinetics of Benfo-Oxythiamine (B-OT) in Healthy Volunteers PHASE1COMPLETED
A Phase I Trial of SHR3162 in Subjects With Advanced Solid Tumors PHASE1COMPLETED
Phase 1a Single Ascending Dose Study of MIB-725 in Healthy Adults PHASE1RECRUITING
ABT-888 Plus Metronomic Cyclophosphamide to Treat Cancer PHASE1COMPLETED
Tracing the Metabolic Flux of Orally Administered NAD+ Precursors PHASE1RECRUITING
PET Imaging of PARP Activity in Cancer EARLY_PHASE1UNKNOWN
Investigate eNAMPT in Multiple Myeloma Biology and Establish Its Role in Disease Progression nanCOMPLETED
Dried Fruit and Postprandial Glycemia Trial nanUNKNOWN
Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With Nicotinamide Riboside nanUNKNOWN
Natural History of GACI With or Without ARHR2 or PXE nanUNKNOWN
Role and Interactions of Adenosine, Receptors, Methionine Cycle Nutritional, Metabolic and Genetic Determinants in the Onset of Atrial Fibrillation in Normal Heart nanUNKNOWN
Genetic Variants and Regulation of Specialized Pro-resolving Mediator nanRECRUITING
Signaling Pathways Targeting Colorectal Cancer in Egypt nanCOMPLETED
The Safety and Efficacy Study of RiaGev in Healthy Adults nanUNKNOWN
A Proof of Concept Study for the DNA Repair Driven by the Mesenchymal Stem Cells in Critical COVID-19 Patients nanCOMPLETED
Natural History of PRPF31 Mutation-Associated Retinal Dystrophy nanACTIVE_NOT_RECRUITING
Sirtuin1 in COVID19 Patients nanUNKNOWN
Identifying Genes and Mutations Underlying Retinitis Pigmentosa and Allied Diseases nanUNKNOWN
Role of Genetic Factors in the Development of Lung Disease nanRECRUITING
Plant-based Diets and Body Weight and Selected Metabolic Parameters Management in Obese Patients. nanCOMPLETED
A Retrospective Study to Identify New Omics Biomarkers of Chronic/Persistent Low Back Pain nanCOMPLETED
Thiamine As An Adjuvant Therapy For Hyperlactatemia In Septic Shock Patients nanUNKNOWN
Proof of Concept Creatine Supplementation for Homocystinuria Study nanACTIVE_NOT_RECRUITING
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation nanCOMPLETED
Polycystic Ovary Syndrome in Type 1 Diabetes nanNOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a PRPS1 binder may also engage these)

ProteinNameSimilarity
Q2HJ58 — 1.000 Q2HJ58 →
Q5RFJ7 — 1.000 Q5RFJ7 →
P60892 — 1.000 P60892 →
Q9D7G0 — 1.000 Q9D7G0 →
Q4R4U3 — 1.000 Q4R4U3 →
Q5R8F8 — 1.000 Q5R8F8 →
Q4R4R7 — 1.000 Q4R4R7 →
P09330 — 1.000 P09330 →
P11908 — 1.000 P11908 →
Q5XGI0 — 1.000 Q5XGI0 →
Q7ZXC9 — 1.000 Q7ZXC9 →
Q9CS42 — 1.000 Q9CS42 →
P21108 — 1.000 P21108 →
O94413 — 1.000 O94413 →
Q5ZI49 — 1.000 Q5ZI49 →
Q8E7X8 — 0.999 Q8E7X8 →
Q8UDA9 — 0.999 Q8UDA9 →
Q8EZN0 — 0.999 Q8EZN0 →
P44328 — 0.999 P44328 →
Q9ZLA1 — 0.998 Q9ZLA1 →
Q6GBY8 — 0.998 Q6GBY8 →
P56184 — 0.998 P56184 →
P65236 — 0.998 P65236 →
Q6GJH1 — 0.998 Q6GJH1 →
Q82TQ4 — 0.997 Q82TQ4 →
Q8E2H0 — 0.997 Q8E2H0 →
P65235 — 0.997 P65235 →
Q0C5A1 — 0.997 Q0C5A1 →
P65237 — 0.997 P65237 →
Q54PA9 — 0.997 Q54PA9 →