Sugi Predict

Sugi Predict / Targets / RAB27A

RAB27A

Ras-related protein Rab-27A · P51159 · RAB27A on Sugi Atlas →

423 patent compounds predicted against RAB27A, 232 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL27369718 SCHEMBL27369718 1.00 1/20
SCHEMBL27940494 SCHEMBL27940494 1.00 1/20
SCHEMBL28895762 SCHEMBL28895762 1.00 1/20
SCHEMBL29430172 SCHEMBL29430172 1.00 1/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL31060375) 0.99 1/20
SCHEMBL26504048 SCHEMBL26504048 0.75 1/20
SCHEMBL17643531 SCHEMBL17643531 0.71 1/20
SCHEMBL19188284 SCHEMBL19188284 0.71 1/20
SCHEMBL8781975 SCHEMBL8781975 0.69 1/20
SCHEMBL8781976 SCHEMBL8781976 0.69 1/20
SCHEMBL17643556 SCHEMBL17643556 0.69 1/20
SCHEMBL19178453 SCHEMBL19178453 0.69 1/20
SCHEMBL8781966 SCHEMBL8781966 0.67 1/20
SCHEMBL8781969 SCHEMBL8781969 0.67 1/20
SCHEMBL27940542 SCHEMBL27940542 0.67 1/20
SCHEMBL26503869 SCHEMBL26503869 0.64 1/20
SCHEMBL10812912 SCHEMBL10812912 0.63 1/20
SCHEMBL10812915 SCHEMBL10812915 0.63 1/20
SCHEMBL10992987 SCHEMBL10992987 0.61 1/20
SCHEMBL10992996 SCHEMBL10992996 0.61 1/20

Clinical trials — most relevant to RAB27A by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Treatment With HMG-COA Reductase Inhibitor of Growth and Bone Abnormalities in Children With Noonan Syndrome PHASE3COMPLETED
Safety and Efficacy of AAV9/AP4B1 (BFB-101) For Patients With AP4B1-related Hereditary Spastic Paraplegia Type 47 (SPG47) PHASE1/PHASE2NOT_YET_RECRUITING
A Study of Hydroxychloroquine in Combination With Gemcitabine/Abraxane in Pancreatic Cancer PHASE1/PHASE2COMPLETED
Melpida: Recombinant Adeno-associated Virus (serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt) PHASE1/PHASE2RECRUITING
Phase 2 Study of REOLYSIN® in Combination With Paclitaxel and Carboplatin for Non-Small Cell Lung Cancer With KRAS or EGFR Activation PHASE2COMPLETED
Phase I Study of Novel Estrogen Receptor(ER) a36 Modifier Icaritin in Advanced Breast Cancer Patients PHASE1UNKNOWN
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma PHASE1COMPLETED
Identification of New Biomarkers of Insulin Resistance nanACTIVE_NOT_RECRUITING
Rab 32 Gene Polymorphisms as a Prognostic Factor in Leprosy Patients nanRECRUITING
Acceptance and Commitment Therapy for Caregivers of Children With a RASopathy: An Internal Pilot Feasibility Study and Follow-up Randomized Controlled Trial nanRECRUITING
Fox BioNet Project: LRRK2-002 nanCOMPLETED
Study of Chediak-Higashi Syndrome nanRECRUITING
Assessing the Polygenic Burden of Rare Disruptive Mutations in Parkinson's Disease nanUNKNOWN
Study of the Pathophysiological Mechanisms Involved in Bleeding Events nanCOMPLETED
Consortium On Risk for Early-onset Parkinson's Disease (CORE PD) nanCOMPLETED
Genetic Characterization of Parkinson's Disease nanCOMPLETED
Hong Kong Spinocerebellar Ataxias Registry nanRECRUITING
Combining Gene Variants to Improve Risk Prediction for Metabolic (Dysfunction)- Associated Fatty Liver Disease and Its Progression to Cirrhosis in Indian Individuals With Type 2 Diabetes nanCOMPLETED
Value of MicroRNA30a in Philadelphia Positive Leukemic Patients nanUNKNOWN
Natural History Study of SLC25A46 Mutation-related Mitochondriopathy nanCOMPLETED
Genetic Variation in TRAF3IP2 (rs13190932) nanRECRUITING
Pubertal Development in Patients with RASopathies nanRECRUITING
The Genetic Study of Primary Angle-Closure Glaucoma nanUNKNOWN
Genetic Study of Patients With Primary Ciliary Dyskinesia nanCOMPLETED
commd7 Gene Expression in ALL nanUNKNOWN
Association of Autophagy-related Genes ,LncRNA and SNPs With Colorectal Cancer in Egyptian Population nanCOMPLETED
RASopathy Biorepository nanRECRUITING
Parkinson's Families Project nanRECRUITING
Autophagy in Systemic Lupus Erythematosus nanUNKNOWN
Gene Analysis of Parkinson's Disease nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a RAB27A binder may also engage these)

ProteinNameSimilarity
Q9ERI2 — 1.000 Q9ERI2 →
Q1HE58 — 1.000 Q1HE58 →
Q4LE85 — 1.000 Q4LE85 →
P23640 — 0.999 P23640 →
Q8HZJ5 — 0.999 Q8HZJ5 →
O00194 — 0.997 O00194 →
Q99P74 — 0.996 Q99P74 →
Q99P58 — 0.995 Q99P58 →
Q5ZLG1 — 0.993 Q5ZLG1 →
O42819 — 0.993 O42819 →
Q96E17 — 0.993 Q96E17 →
P25228 — 0.993 P25228 →
RAB39A Ras-related protein Rab-39A 0.993 landscape →
P62823 — 0.993 P62823 →
Q9SMR4 — 0.992 Q9SMR4 →
Q0IIG8 — 0.992 Q0IIG8 →
P16976 — 0.992 P16976 →
Q5R5H5 — 0.992 Q5R5H5 →
Q9CB01 — 0.992 Q9CB01 →
Q8BHD0 — 0.991 Q8BHD0 →
P63011 — 0.991 P63011 →
Q18969 — 0.991 Q18969 →
C4YL11 — 0.991 C4YL11 →
Q68EK7 — 0.991 Q68EK7 →
P11023 — 0.991 P11023 →
Q9JKM7 — 0.991 Q9JKM7 →
Q5R4W9 — 0.991 Q5R4W9 →
Q54DA7 — 0.991 Q54DA7 →
O49841 — 0.991 O49841 →
Q43463 — 0.990 Q43463 →