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RAB6A

Ras-related protein Rab-6A · P20340 · RAB6A on Sugi Atlas →

224 patent compounds predicted against RAB6A, 215 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Barasertib Barasertib (SCHEMBL613582) 1.00 1/20
Barasertib Barasertib (SCHEMBL29368256) 1.00 1/20
Barasertib Barasertib (SCHEMBL29720420) 1.00 1/20
SCHEMBL3490131 SCHEMBL3490131 0.96 1/20
SCHEMBL4275319 SCHEMBL4275319 0.94 1/20
SCHEMBL3489414 SCHEMBL3489414 0.93 1/20
SCHEMBL12132713 SCHEMBL12132713 0.92 1/20
SCHEMBL613581 SCHEMBL613581 0.91 1/20
SCHEMBL3862878 SCHEMBL3862878 0.90 1/20
SCHEMBL3489712 SCHEMBL3489712 0.90 1/20
SCHEMBL12132714 SCHEMBL12132714 0.90 1/20
SCHEMBL3858181 SCHEMBL3858181 0.89 1/20
SCHEMBL12101935 SCHEMBL12101935 0.87 1/20
SCHEMBL25645281 SCHEMBL25645281 0.87 1/20
SCHEMBL1345032 SCHEMBL1345032 0.86 1/20
SCHEMBL3860607 SCHEMBL3860607 0.86 1/20
SCHEMBL1345874 SCHEMBL1345874 0.85 1/20
SCHEMBL3489570 SCHEMBL3489570 0.84 1/20
SCHEMBL3489829 SCHEMBL3489829 0.83 1/20
SCHEMBL3491964 SCHEMBL3491964 0.82 1/20

Clinical trials — most relevant to RAB6A by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Melpida: Recombinant Adeno-associated Virus (serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt) PHASE1/PHASE2RECRUITING
Safety and Efficacy of AAV9/AP4B1 (BFB-101) For Patients With AP4B1-related Hereditary Spastic Paraplegia Type 47 (SPG47) PHASE1/PHASE2NOT_YET_RECRUITING
Antioxidant Therapy With N-acetylcysteine for Learning and Motor Behavior in Children With Neurofibromatosis Type 1 PHASE2COMPLETED
Expression and Function of the Renin-Angiotensin System in the Esophagus EARLY_PHASE1COMPLETED
Pediatric Reporting of Adult-Onset Genomic Results EARLY_PHASE1COMPLETED
Acceptance and Commitment Therapy for Caregivers of Children With a RASopathy: An Internal Pilot Feasibility Study and Follow-up Randomized Controlled Trial nanRECRUITING
Identification of New Biomarkers of Insulin Resistance nanACTIVE_NOT_RECRUITING
Rab 32 Gene Polymorphisms as a Prognostic Factor in Leprosy Patients nanRECRUITING
Clinical Genetics Branch Eligibility Screening Survey nanNOT_YET_RECRUITING
Assessing the Polygenic Burden of Rare Disruptive Mutations in Parkinson's Disease nanUNKNOWN
Prospective Natural History Study of Retinitis Pigmentosa nanACTIVE_NOT_RECRUITING
RASopathy Biorepository nanRECRUITING
Consortium On Risk for Early-onset Parkinson's Disease (CORE PD) nanCOMPLETED
Gene Analysis of Parkinson's Disease nanCOMPLETED
Clinical, Genetic, and Epidemiologic Study of Children and Adults With RASopathies nanRECRUITING
Genetics of Rolandic Epilepsy nanCOMPLETED
Pubertal Development in Patients with RASopathies nanRECRUITING
Genetic Evaluation of NF1 and Scoliosis Patients nanCOMPLETED
Genetic Characterization of Parkinson's Disease nanCOMPLETED
Study of the Pathophysiological Mechanisms Involved in Bleeding Events nanCOMPLETED
Prevalence and Characterization of Pain in RASopathies nanUNKNOWN
Whole-genome Sequencing Study in Patients With Diminished Ovarian Reserve nanUNKNOWN
Genetic Study of Patients With Primary Ciliary Dyskinesia nanCOMPLETED
Study of Chediak-Higashi Syndrome nanRECRUITING
Parkinson's Families Project nanRECRUITING
Investigating Phenotypic, Epigenetic, and NeuroGenetic Traits in Rare and Ultra-rare Neurodevelopmental Disorders (Project PENGUIN) nanRECRUITING
Biomarker Research in Inherited Movement Disorders nanRECRUITING
Rolandic Epilepsy Genomewide Association International Study nanCOMPLETED
Gait in Rare Diseases nanCOMPLETED
Autophagy in Systemic Lupus Erythematosus nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a RAB6A binder may also engage these)

ProteinNameSimilarity
Q5RAV6 — 1.000 Q5RAV6 →
P35279 — 1.000 P35279 →
Q1KME6 — 1.000 Q1KME6 →
Q9WVB1 — 1.000 Q9WVB1 →
A6QR46 — 1.000 A6QR46 →
Q9NRW1 — 1.000 Q9NRW1 →
O18334 — 1.000 O18334 →
Q9SMR4 — 1.000 Q9SMR4 →
Q9LFT9 — 0.999 Q9LFT9 →
P17608 — 0.997 P17608 →
Q22782 — 0.997 Q22782 →
P61294 — 0.997 P61294 →
Q9SID8 — 0.996 Q9SID8 →
Q9LV79 — 0.995 Q9LV79 →
Q96E17 — 0.994 Q96E17 →
P34213 — 0.994 P34213 →
Q5ZLG1 — 0.994 Q5ZLG1 →
Q8MXS1 — 0.994 Q8MXS1 →
O80501 — 0.994 O80501 →
Q54DA7 — 0.993 Q54DA7 →
Q9SF92 — 0.993 Q9SF92 →
O49841 — 0.993 O49841 →
RAB39A Ras-related protein Rab-39A 0.993 landscape →
Q8HZJ5 — 0.993 Q8HZJ5 →
F1PTE3 — 0.993 F1PTE3 →
P62823 — 0.993 P62823 →
P25228 — 0.992 P25228 →
P35281 — 0.992 P35281 →
Q0IIG8 — 0.992 Q0IIG8 →
P35286 — 0.992 P35286 →