RCC1

Regulator of chromosome condensation · P18754 · RCC1 on Sugi Atlas →

828 patent compounds predicted against RCC1, 719 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Rebastinib (SCHEMBL2034290)	1.00	1/20
Rebastinib (SCHEMBL2026623)	0.99	1/20
SCHEMBL2029025	0.86	1/20
Hydrochloric Acid (SCHEMBL5057169)	0.85	1/20
SCHEMBL2028677	0.83	1/20
Hydrochloric Acid (SCHEMBL2029657)	0.83	1/20
Hydrochloric Acid (SCHEMBL2031193)	0.82	1/20
SCHEMBL2029929	0.82	1/20
Hydrochloric Acid (SCHEMBL2025402)	0.81	1/20
SCHEMBL2243266	0.80	1/20
SCHEMBL2241121	0.78	1/20
SCHEMBL2242285	0.78	1/20
SCHEMBL2242769	0.78	1/20
SCHEMBL2031683	0.78	1/20
SCHEMBL5052381	0.78	1/20
SCHEMBL5056329	0.78	1/20
SCHEMBL2242856	0.78	1/20
SCHEMBL2243075	0.78	1/20
SCHEMBL2026550	0.78	1/20
SCHEMBL2243259	0.77	1/20

Clinical trials — most relevant to RCC1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Cornelia De Lange Syndrome: Assessing Positive Effects of Lithium Treatment	PHASE2/PHASE3	RECRUITING
Compared the Efficacy and Safety of CDOP Combined With Chidamide and CDOP in de Novo Peripheral T Cell Lymphoma Patients	PHASE3	UNKNOWN
PhII 5-Azacytidine Plus Valproic Acid and Eventually Atra in Intermediate II and High Risk MDS	PHASE2	COMPLETED
A Phase Ib/II Clinical Study Evaluating the Safety and Efficacy of Tislelizumab in Combination With Golidocitinib and Selinexor for the Treatment of R/R NKTCL	PHASE1/PHASE2	RECRUITING
Axitinib in1st Line Treatment for Patients With Advanced or Metastatic Papillary Renal Cell Carcinoma	PHASE2	COMPLETED
INCB018424 in Patients With Advanced Hematologic Malignancies	PHASE2	COMPLETED
Phase I Dose Finding and Proof-of-concept Study of Panobinostat With Standard Dose Cytarabine and Daunorubicin for Untreated Acute Myeloid Leukemia or Advanced Myelodysplastic Syndrome	PHASE1	COMPLETED
Phase I Study to Assess the Safety, Pharmacokinetics, & Pharmacodynamics of GSK923295 in Subjects w/ Refractory Cancer	PHASE1	COMPLETED
Imetelstat for Children With Refractory or Recurrent Solid Tumors and Lymphoma	PHASE1	WITHDRAWN
PS-341 and Radiation to Treat Advanced Cancer of the Head and Neck	PHASE1	COMPLETED
PCM1-JAK2 in Therapy Related Neoplasms	nan	UNKNOWN
Post Market Surveillance & Post Market Clinical Follow up, International, Medical Registry to Confirm the Safety and the Performance of the Anecova Intra Uterine Culture Device	nan	WITHDRAWN
Multi-Dimensional Genomic Dissection of Ring Chromosome 14 Syndrome	nan	ACTIVE_NOT_RECRUITING
Immunophenotyping and Xist Gene in AML	nan	UNKNOWN
Proteomic-Based Profiling of Lymphomas: Chromatin Proteomics; Composition and Modification of Histone and Non-Histone Chromosomal Proteins	nan	COMPLETED
Harvest of CTCs From MBC Patients Using the Parsortix™ PC1 System	nan	COMPLETED
Role of the Nuclear Pore Component RANBP2 in Inflammatory Responses to Viral Infections	nan	COMPLETED
A Clinical Study on the Efficacy and Safety of Methotrexate (MTX) or Thiotepa (for MTX Intolerance) or Temozolomide (TMZ) Combined With Orelabrutinib and Selinexor in Relapsed/Refractory Primary or Secondary Central Nervous System Lymphoma（SELINA）	nan	RECRUITING
Telomeric Abnormalities in Colorectal Diseases by Fluorescent in Situ Hybridization Technique	nan	UNKNOWN
LINC00511/miR-185-3p Axis and miR-301a-3p Markers for Breast Cancer Diagnosis	nan	COMPLETED
Genetic Investigation of Solid Tumors Cohort	nan	COMPLETED
Impact of Ionizing Treatment on the Nuclear Structure of Human Spermatozoa.	nan	UNKNOWN
EKLF Gene Expression in β-thalassemia	nan	NOT_YET_RECRUITING
Efect of Quinoa and Flaxseed in Cititoxicity and Glicemic Control in Metabolic Syndrome Patients	nan	UNKNOWN
Cell Membrane Potential Regulates Spatial-Specific Mechanoptosis Resistance and Metastasis in Colorectal Cancer Via Mechanotransduction and the PVR/CD96 Axis	nan	COMPLETED
Role of Geminin and Mcm-2 in Prognosis of Renal Cell Carcinoma	nan	UNKNOWN
Effect of Adenovirus E1A Oncogene on DNA Replication Dynamics	nan	UNKNOWN
Long Non-coding RNAs and Their Role on Epigenome as Diagnostic Markers in Childhood Acute Lymphoblastic Leukemia of T Cells.	nan	UNKNOWN
Biological Aging Hallmarks-Guided Integrative TCM and Conventional Medicine in Post-Treatment Unexplained Female Infertility	nan	RECRUITING
DNA Methylation and Autoimmune Thyroid Diseases	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a RCC1 binder may also engage these)

Protein	Name	Similarity
Q8VE37	—	1.000	Q8VE37 →
P23800	—	1.000	P23800 →
P25183	—	1.000	P25183 →
P21827	—	0.977	P21827 →
Q90XC2	—	0.976	Q90XC2 →
P25171	—	0.975	P25171 →
Q9FN03	—	0.972	Q9FN03 →
Q91ZR4	—	0.972	Q91ZR4 →
O42645	—	0.970	O42645 →
P28745	—	0.968	P28745 →
NEK8	Serine/threonine-protein kinase Nek8	0.968	landscape →
Q95JL5	—	0.966	Q95JL5 →
F4I1S7	—	0.966	F4I1S7 →
Q04199	—	0.966	Q04199 →
Q9LFE2	—	0.966	Q9LFE2 →
D3ZGQ5	—	0.965	D3ZGQ5 →
Q68FJ6	—	0.964	Q68FJ6 →
Q9UGK8	—	0.964	Q9UGK8 →
Q6NX08	—	0.964	Q6NX08 →
Q2KJH4	—	0.963	Q2KJH4 →
P52499	—	0.963	P52499 →
Q7QBJ0	—	0.963	Q7QBJ0 →
Q7ZZC8	—	0.963	Q7ZZC8 →
Q18211	—	0.962	Q18211 →
B6K1G6	—	0.962	B6K1G6 →
Q9LV35	—	0.962	Q9LV35 →
Q8BU03	—	0.962	Q8BU03 →
Q5GLZ8	—	0.962	Q5GLZ8 →
P31386	—	0.961	P31386 →
Q8H594	—	0.961	Q8H594 →