RHOT2

Mitochondrial Rho GTPase 2 · Q8IXI1 · RHOT2 on Sugi Atlas →

0 patent compounds predicted against RHOT2, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours

Clinical trials — most relevant to RHOT2 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Use of New Drug QRX-3 for Prevention and Treatment of Chronic Kidney Disease Progression PHASE2/PHASE3NOT_YET_RECRUITING
Clinical Evaluation of the Effect of Metformin in Sepsis PHASE3UNKNOWN
Nicotinamide in Glaucoma (NAMinG): A Randomised, Placebo-controlled, Multi-centre, Phase III Trial PHASE3RECRUITING
A Study of the Efficacy and Safety of MT1621 in Thymidine Kinase 2 (TK2) Deficiency (Treatment naïve) PHASE3WITHDRAWN
Relative Mitochondrial Toxicity of Tenofovir Alafenamide (TAF) vs. Tenofovir Disoproxil Fumarate (TDF) PHASE1/PHASE2COMPLETED
ONC201 in Recurrent/Refractory Metastatic Breast Cancer and Advanced Endometrial Carcinoma PHASE2COMPLETED
Biologic Correlative Taxotere/AC PHASE2COMPLETED
Clinical Effects of Alpha-Lipoic Acid in Advanced NSCLC PHASE2NOT_YET_RECRUITING
Dynamics of Muscle Mitochondria in Type 2 Diabetes (DYNAMMO T2D) EARLY_PHASE1COMPLETED
Dynamics of Muscle Mitochondria in Type 2 Diabetes Exercise nanCOMPLETED
Study of the Pathophysiological Mechanisms Involved in Bleeding Events nanCOMPLETED
ADRB3, ROCK2 and GEF Levels in Overactive Bladder Patients nanCOMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes nanCOMPLETED
Skeletal Muscle Regeneration in Survivors of Critical Illness: How to Prevent Satellite Cell Failure? nanRECRUITING
Tissue Sample Study for Mitochondrial Disorders nanENROLLING_BY_INVITATION
Relationship Between Mitochondrial Dysfunction and Fatique in Cancer Patients Following External Beam Radiation Therapy nanCOMPLETED
Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy Men nanRECRUITING
Exercise-mediated Rescue of Mitochondrial Dysfunctions Driving Insulin Resistance nanCOMPLETED
Cell Studies of Parkinson's Disease nanCOMPLETED
MERC Proteins in Saliva and GCF in Periodontal Disease (ELISA Study) nanCOMPLETED
Clinical Study of Hydroxytyrosol (HT) in Mitochondrial Diseases nanCOMPLETED
Pathogenic Insights and Search for Biomarkers in RFC1-ataxia/CANVAS nanRECRUITING
Mitochondrial Dysfunctions Driving Insulin Resistance nanCOMPLETED
Measuring Protein Turnover in Humans Across the Lifespan by Metabolic Labeling With Deuterium Oxide nanRECRUITING
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes nanNOT_YET_RECRUITING
Combined Effects of Statins and Exercise on Training Sensitive Health Markers nanCOMPLETED
Gastrointestinal Dysfunction in Children Affected With Mitochondrial Disorders nanCOMPLETED
In and ex Vivo Mitochondrial Function of the Heart nanCOMPLETED
Cerebrospinal Fluid Mitochondrial Biomarkers in Ischemic Stroke and Alzheimer Disease nanRECRUITING
Transgenerational Metabolic-Immune Biomarkers of Neurological and Neurodevelopmental Disorders nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a RHOT2 binder may also engage these)

ProteinNameSimilarity
Q7TSA0 1.000 Q7TSA0 →
Q8JZN7 1.000 Q8JZN7 →
Q5E9M9 1.000 Q5E9M9 →
Q864R5 0.991 Q864R5 →
Q6DIS1 0.981 Q6DIS1 →
Q32LU1 0.979 Q32LU1 →
MAP4K2 Mitogen-activated protein kinase kinase kinase kinase 2 0.968 landscape →
LPCAT1 Lysophosphatidylcholine acyltransferase 1 0.967 landscape →
Q5ZM83 0.965 Q5ZM83 →
Q9Z268 0.965 Q9Z268 →
O97583 0.965 O97583 →
Q148G5 0.964 Q148G5 →
O43272 0.963 O43272 →
NOX5 NADPH oxidase 5 0.963 landscape →
Q61161 0.963 Q61161 →
Q1HAQ0 0.962 Q1HAQ0 →
D3ZAA9 0.962 D3ZAA9 →
Q9WV34 0.960 Q9WV34 →
Q3UFQ8 0.960 Q3UFQ8 →
Q3TFD2 0.960 Q3TFD2 →
P10463 0.959 P10463 →
Q5XHY1 0.959 Q5XHY1 →
PKN1 Serine/threonine-protein kinase N1 0.959 landscape →
Q66JN8 0.959 Q66JN8 →
Q9BSK4 0.958 Q9BSK4 →
TRPM4 Transient receptor potential cation channel subfamily M member 4 0.958 landscape →
Q8ND23 0.958 Q8ND23 →
P70268 0.958 P70268 →
Q5TM59 0.957 Q5TM59 →
NPR1 Atrial natriuretic peptide receptor 1 0.957 landscape →