SIRT6

NAD-dependent protein deacylase sirtuin-6 · Q8N6T7 · SIRT6 on Sugi Atlas →

75,808 patent compounds predicted against SIRT6, 59,016 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL77148	1.00	7/20
SCHEMBL44865	0.44	4/20
SCHEMBL111292	0.65	3/20
SCHEMBL40388	0.55	3/20
Oleic Acid (SCHEMBL1138)	1.00	2/20
Oleic Acid (SCHEMBL1139)	1.00	2/20
Fluvastatin (SCHEMBL2846)	1.00	2/20
Fluvastatin (SCHEMBL2847)	1.00	2/20
Fluvastatin (SCHEMBL2848)	1.00	2/20
Fluvastatin (SCHEMBL2849)	1.00	2/20
Erucic Acid (SCHEMBL5987)	1.00	2/20
Erucic Acid (SCHEMBL5988)	1.00	2/20
Erucic Acid (SCHEMBL6297)	1.00	2/20
Elaidic Acid (SCHEMBL6693)	1.00	2/20
Linoleic Acid (SCHEMBL7067)	1.00	2/20
SCHEMBL19452	1.00	2/20
Nervonic Acid (SCHEMBL21103)	1.00	2/20
Nervonic Acid (SCHEMBL21104)	1.00	2/20
Palmitoleic Acid (SCHEMBL33310)	1.00	2/20
Palmitoleic Acid (SCHEMBL33311)	1.00	2/20

Clinical trials — most relevant to SIRT6 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Cardiotoxicity in Breast Cancer Patients	PHASE4	RECRUITING
cindilizumab + Bevacizumab + Coenzyme I for Injection in Unresectable Hepatocellular Carcinoma	PHASE4	UNKNOWN
Compared the Efficacy and Safety of CDOP Combined With Chidamide and CDOP in de Novo Peripheral T Cell Lymphoma Patients	PHASE3	UNKNOWN
Sirtuin-NAD Activator in Alzheimer's Disease	PHASE1/PHASE2	ACTIVE_NOT_RECRUITING
A Study of APO866 for the Treatment of Cutaneous T-cell Lymphoma	PHASE2	COMPLETED
Nitrites, Skeletal Muscle Mitochondrial Bioenergetics, and Physical Activity in Old Age	PHASE2	COMPLETED
Oral Nitrite for Older Heart Failure Patients	PHASE2	COMPLETED
NADream: Effects of Nicotinamide Adenine Dinucleotide Supplementation on Sleep Quality in Healthy Individuals	PHASE2	RECRUITING
The Safety and Efficacy of an NAD+ Boosting Product Together With a Low Carbohydrate Diet in Adults With Mild Hypertension and Eligible for Normal-standard-of-care	PHASE2	COMPLETED
Effects of Vitamin B3 in Patients With Ataxia Telangiectasia	PHASE2	COMPLETED
A Study to Assess APO866 for the Treatment of Advanced Melanoma	PHASE2	COMPLETED
Phase 1a Single Ascending Dose Study of MIB-725 in Healthy Adults	PHASE1	RECRUITING
Tracing the Metabolic Flux of Orally Administered NAD+ Precursors	PHASE1	RECRUITING
Project SIRT6 Activator	nan	RECRUITING
Sirtuin1 in COVID19 Patients	nan	UNKNOWN
Influence of WNT4 VEZT FSHB and SIRT1 SNPs in Endometriosis: a Case Control Study of the Sardinian Population	nan	UNKNOWN
Impact of Nicotinamide Riboside (NR) on Kidney Function in Patients Undergoing Cardiac Surgery	nan	NOT_YET_RECRUITING
How Sirtuin Levels Change During Behçet Disease	nan	UNKNOWN
Role of Fasted Exercise on Improving Cardiometabolic Health	nan	UNKNOWN
Sirtuin 3 and Sirtuin 7 in Systemic Sclerosis	nan	UNKNOWN
Comparison of Cardiometabolic Markers in Individuals With Hypertriglyceridemia With Low and High Weight Loss Responses to an Energy-restricted Diet	nan	COMPLETED
Inflammation in COPD and the Effect of Nicotinamide Riboside	nan	COMPLETED
Calorie Restriction Retards the Aging Process	nan	UNKNOWN
Investigate eNAMPT in Multiple Myeloma Biology and Establish Its Role in Disease Progression	nan	COMPLETED
Short Interval Resveratrol Trial in Cardiovascular Surgery	nan	ACTIVE_NOT_RECRUITING
The Safety and Efficacy Study of RiaGev in Healthy Adults	nan	UNKNOWN
Nutritional Intervention-induced Weight Loss During the Oncological Treatment of Obesity-related Breast Cancer	nan	UNKNOWN
Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With Nicotinamide Riboside	nan	UNKNOWN
Low Sirtuin-1 Levels Are Linked to Erythropoietin Resistance in Hemodialysis Patients.	nan	COMPLETED
Effects of Protein Hydrolysate Supplement on Systemic Muscle Function Markers Following Resistance Type Exercise in Male Subjects	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a SIRT6 binder may also engage these)

Protein	Name	Similarity
P59941	—	0.999	P59941 →
A0A2K5TU92	—	0.999	A0A2K5TU92 →
A0A250YGJ5	—	0.995	A0A250YGJ5 →
Q5AW69	—	0.976	Q5AW69 →
Q8BKJ9	—	0.975	Q8BKJ9 →
B2RZ55	—	0.974	B2RZ55 →
Q0P595	—	0.973	Q0P595 →
SIRT7	NAD-dependent protein deacetylase sirtuin-7	0.972	landscape →
E9GD30	—	0.972	E9GD30 →
Q5R6G3	—	0.971	Q5R6G3 →
Q5RBF1	—	0.971	Q5RBF1 →
E1BRE2	—	0.970	E1BRE2 →
F7DKV7	—	0.968	F7DKV7 →
P27967	—	0.968	P27967 →
Q68FX9	—	0.968	Q68FX9 →
P16081	—	0.968	P16081 →
Q5RJQ4	—	0.968	Q5RJQ4 →
A8NWP2	—	0.968	A8NWP2 →
P27968	—	0.967	P27968 →
Q6DHI5	—	0.967	Q6DHI5 →
F7EZ75	—	0.967	F7EZ75 →
A0A0J9UVG7	—	0.967	A0A0J9UVG7 →
Q3ZBQ0	—	0.967	Q3ZBQ0 →
Q9NWZ5	—	0.966	Q9NWZ5 →
Q8R104	—	0.966	Q8R104 →
Q5HZN8	—	0.965	Q5HZN8 →
O54747	—	0.965	O54747 →
Q0CLW8	—	0.965	Q0CLW8 →
Q4R834	—	0.965	Q4R834 →
Q58H57	—	0.965	Q58H57 →