SLC43A1

Large neutral amino acids transporter small subunit 3 · O75387 · SLC43A1 on Sugi Atlas →

52 patent compounds predicted against SLC43A1, 8 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL31492022 SCHEMBL31492022 0.71 1/20
SCHEMBL29913533 SCHEMBL29913533 0.56 1/20
SCHEMBL29386450 SCHEMBL29386450 0.56 1/20
SCHEMBL22707424 SCHEMBL22707424 0.46 1/20
SCHEMBL27057771 SCHEMBL27057771 0.41 1/20
SCHEMBL29569931 SCHEMBL29569931 0.41 1/20
SCHEMBL15491009 SCHEMBL15491009 0.40 1/20
SCHEMBL15492800 SCHEMBL15492800 0.40 1/20

Clinical trials — most relevant to SLC43A1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Effects of Kuvan on Melatonin Secretion PHASE4COMPLETED
Effect of Age on the Renal Clearance of Adefovir PHASE4WITHDRAWN
L-arginine Treatment in Mild Hypertension PHASE4UNKNOWN
Pharmacogenetic Treatment With Anti-Glutaminergic Agents for Comorbid PTSD & AUD PHASE3COMPLETED
First-in-Human Evaluation of an Astrocytic Glutamate Transporter (EAAT2) PET Tracer in Dementia PHASE1/PHASE2RECRUITING
DAAOI-1 Treatment for Treatment-resistant Schizophrenia PHASE2COMPLETED
D-amino Acid Oxidase Inhibition (DAAOI-1) add-on Treatment for Chronic Schizophrenia PHASE2COMPLETED
Influence of the OATP1B1 and OATP1B3 Genotype on the Hepatic Uptake of Primovist® PHASE1/PHASE2COMPLETED
Therapeutic Efficacy of L-Ornithine L-Aspartate Infusion in Patients With Acute Liver Failure PHASE2UNKNOWN
Effect of, OAT3, on the Renal Secretion of Cefotaxime PHASE1COMPLETED
Identification and Validation of Biomarkers for Breast Cancer Resistance Protein (BCRP) PHASE1COMPLETED
Drug-drug Interaction Study in Healthy Male Volunteers Following the Administration of Pantoprazole and Rosuvastatin PHASE1COMPLETED
PK and PD of YG1699 in CKD Patients With Diabetes PHASE1NOT_YET_RECRUITING
Pharmacokinetic Drug-Drug Interaction Study to Identify Biomarkers of Kidney Transporters EARLY_PHASE1COMPLETED
Gadoxetate Sodium Enhanced MRI as a Biomarker for Aggressive Prostate Cancer EARLY_PHASE1UNKNOWN
Metformin Gastrointestinal Intolerance: Measurement of Mitochondrial Complex I EARLY_PHASE1COMPLETED
[18F] FDOPA PET Imaging in Glioma: Feasibility Study for PET Guided Brain Biopsy nanUNKNOWN
Additional Dietary Large Neutral Amino Acids (LNAA) for Improved Symptoms in Adult Classical Phenylktonuria (PKU) nanUNKNOWN
Impact of Polymorphisms of OAT1, OAT3, and OCT2 on Transportation of Potential Nephrotoxic Drugs nanCOMPLETED
Protein Digestion and Amino Acid Absorption in the Aging Gastrointestinal Tract nanCOMPLETED
Gene Expression in Inflammatory Bowel Disease nanENROLLING_BY_INVITATION
Molecular Epidemiology of Essential Hypertension nanCOMPLETED
Study of ABCB1,SLC22A16 Drug Transporter Genes and Doxorubicin and Cyclophosphamide Toxicity in Brest Cancer Patient nanUNKNOWN
Optimizing Protein Patterns for Skeletal Muscle Preservation and Sleep in the Medical Management of Parkinson Disease nanCOMPLETED
18F-FDOPA PET in Neuroendocrine Tumours nanNO_LONGER_AVAILABLE
A Study of Cases with Abnormal Serum Ammonia in Neonate and Children Attending Assiut University Children Hospital nanNOT_YET_RECRUITING
Insulin Detemir in Obesity Management nanACTIVE_NOT_RECRUITING
Sodium-Endothelial Function-CKD Study nanCOMPLETED
PET/CT Scans Using the Tracer 11C-Csar, a Bile Acid Analog, to Depict and Visualize Cholestatic Disorders in Patients with Genetic Liver Disorders and Healthy Individuals nanENROLLING_BY_INVITATION
Therapeutic Outcomes of Selective Serotonin Reuptake Inhibitors and Phosphodiesterase-5 Inhibitors Combination Therapy Versus Monotherapy nanNOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a SLC43A1 binder may also engage these)

ProteinNameSimilarity
Q8BSM7 1.000 Q8BSM7 →
Q8CGA3 1.000 Q8CGA3 →
Q5RF58 1.000 Q5RF58 →
Q0VCM6 0.997 Q0VCM6 →
Q8N370 0.996 Q8N370 →
A4IHK6 0.990 A4IHK6 →
Q99PL8 0.983 Q99PL8 →
P41438 0.982 P41438 →
Q5BKX6 0.981 Q5BKX6 →
A0A125YQS6 0.980 A0A125YQS6 →
Q8K0H7 0.980 Q8K0H7 →
A1Z7R6 0.980 A1Z7R6 →
B2RXV4 0.980 B2RXV4 →
Q6PDC8 0.979 Q6PDC8 →
Q5RCN7 0.979 Q5RCN7 →
Q9BY10 0.979 Q9BY10 →
Q8CA03 0.979 Q8CA03 →
A9JTG4 0.979 A9JTG4 →
Q9Y5Y0 0.979 Q9Y5Y0 →
Q4LE88 0.979 Q4LE88 →
S8EZA7 0.978 S8EZA7 →
Q5BIZ0 0.978 Q5BIZ0 →
Q04991 0.978 Q04991 →
P42557 0.978 P42557 →
Q9ES43 0.977 Q9ES43 →
Q8K4S3 0.977 Q8K4S3 →
Q93380 0.977 Q93380 →
Q8BIV7 0.977 Q8BIV7 →
Q9N1F2 0.977 Q9N1F2 →
Q6GMG6 0.977 Q6GMG6 →