SLC75A1

Major facilitator superfamily domain-containing protein 10

0 patent compounds predicted against SLC75A1, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

	Compound	Confidence	Supporting neighbours

Germline variants in SLC75A1 on Sugi Variant → ClinVar classifications, population frequency, and predictor agreement (AlphaMissense, SaProt, REVEL) Full SLC75A1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

Clinical trials — most relevant to SLC75A1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effect of Age on the Renal Clearance of Adefovir	PHASE4	WITHDRAWN
A Study Comparing CO-1.01 With Gemcitabine as First Line Therapy in Patients With Metastatic Pancreatic Adenocarcinoma (LEAP)	PHASE2	COMPLETED
Testing the Combination of MLN4924 (Pevonedistat), Carboplatin, and Paclitaxel in Patients With Advanced Non-small Cell Lung Cancer (NSCLC) Who Have Previously Been Treated With Immunotherapy	PHASE2	ACTIVE_NOT_RECRUITING
Study of AR-67 (Formerly DB-67) in Adult Patients With Refractory or Metastatic Solid Malignancies	PHASE1	COMPLETED
THE EFFECT OF CYP3A5 GENOTYPE ON THE PHARMACOKINETICS OF MARAVIROC	PHASE1	COMPLETED
Effect of, OAT3, on the Renal Secretion of Cefotaxime	PHASE1	COMPLETED
Pharmacokinetic Drug-Drug Interaction Study to Identify Biomarkers of Kidney Transporters	EARLY_PHASE1	COMPLETED
Gadoxetate Sodium Enhanced MRI as a Biomarker for Aggressive Prostate Cancer	EARLY_PHASE1	UNKNOWN
Metformin Gastrointestinal Intolerance: Measurement of Mitochondrial Complex I	EARLY_PHASE1	COMPLETED
The Study of Quadruple Therapy Quercetin, Zinc, Metformin, and EGCG as Adjuvant Therapy for Early, Metastatic Breast Cancer and Triple-negative Breast Cancer, a Novel Mechanism	EARLY_PHASE1	UNKNOWN
Natural History Study of SLC25A46 Mutation-related Mitochondriopathy	nan	COMPLETED
SLC13A5 Deficiency Natural History Study - Remote Only	nan	ENROLLING_BY_INVITATION
Role of the ATP7A Transporter in Ovarian Cancer	nan	COMPLETED
Impact of Genetics on Metformin Pharmacokinetics	nan	COMPLETED
Bile Acid Effects in Fetal Arrhythmia Study	nan	UNKNOWN
Hyperlactacidemia in Major Abdominal Surgery and Monocarboxylate Receptors	nan	UNKNOWN
Oxalate and Citrate in Humans - Response to Citrate	nan	RECRUITING
Individualized Antiretroviral Therapy	nan	COMPLETED
Fatty Acid Metabolism and Insulin Sensitivity: the Role of Endurance Exercise	nan	COMPLETED
ADPKD Alterations in Hepatic Transporter Function	nan	COMPLETED
Effect of Pharmacogenetics on Imatinib Plasma Level and Response	nan	COMPLETED
Impact of Polymorphisms of OAT1, OAT3, and OCT2 on Transportation of Potential Nephrotoxic Drugs	nan	COMPLETED
Genetically Guided Statin Therapy	nan	COMPLETED
Epidemiology of Gout in French Polynesia	nan	COMPLETED
Study of CYP2C19 and ALDH3A1 Polymorphisms in Breast Cancer Patients	nan	UNKNOWN
Influence of OCTN2 Variants on Carnitine Status and Plasma Triglycerides	nan	COMPLETED
SLC6A1-NDD Prospective Longitudinal Natural History Study	nan	NOT_YET_RECRUITING
Study of ABCB1,SLC22A16 Drug Transporter Genes and Doxorubicin and Cyclophosphamide Toxicity in Brest Cancer Patient	nan	UNKNOWN
Pharmacogenetics in Non Small Cell Lung Cancer	nan	UNKNOWN
Genetic Variants and Iron Absorption	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a SLC75A1 binder may also engage these)

Protein	Name	Similarity
Q0P5M9	—	0.993	Q0P5M9 →
Q9D2V8	—	0.985	Q9D2V8 →
A6NFX1	—	0.955	A6NFX1 →
SLC67A1	Solute carrier family 22 member 18	0.953	landscape →
A0A3Q2HW92	—	0.952	A0A3Q2HW92 →
Q6NUT3	—	0.951	Q6NUT3 →
Q78KK3	—	0.945	Q78KK3 →
Q3T9M1	—	0.944	Q3T9M1 →
Q6AY78	—	0.943	Q6AY78 →
Q3U481	—	0.935	Q3U481 →
Q58CT4	—	0.934	Q58CT4 →
F1PZV2	—	0.934	F1PZV2 →
O35083	—	0.931	O35083 →
Q95JH0	—	0.930	Q95JH0 →
Q6PDE8	—	0.929	Q6PDE8 →
Q14CX5	—	0.928	Q14CX5 →
Q99943	—	0.927	Q99943 →
Q95JH2	—	0.927	Q95JH2 →
Q91VM4	—	0.924	Q91VM4 →
Q66H95	—	0.924	Q66H95 →
SPNS2	Sphingosine-1-phosphate transporter SPNS2	0.924	landscape →
F1NJ67	—	0.923	F1NJ67 →
Q96SL1	—	0.923	Q96SL1 →
Q8BFQ6	—	0.922	Q8BFQ6 →
Q6TCH4	—	0.919	Q6TCH4 →
Q504N2	—	0.917	Q504N2 →
Q96GM1	—	0.915	Q96GM1 →
Q8VCY8	—	0.914	Q8VCY8 →
D2HKB0	—	0.914	D2HKB0 →
Q6W5G4	—	0.914	Q6W5G4 →