SMPD4

Sphingomyelin phosphodiesterase 4 · Q9NXE4 · SMPD4 on Sugi Atlas →

0 patent compounds predicted against SMPD4, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours

Clinical trials — most relevant to SMPD4 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
A Long-Term Study of Olipudase Alfa in Patients With Acid Sphingomyelinase Deficiency PHASE2COMPLETED
Pentoxifylline as an Adjunctive in Treatment of Negative Symptoms in Chronic Schizophrenia PHASE1/PHASE2COMPLETED
A Phase 1/2 Study of Intravenous Gene Transfer With an AAV9 Vector Expressing Human Beta-galactosidase in Type I and Type II GM1 Gangliosidosis PHASE1/PHASE2RECRUITING
Lovaza's Effect on the Activation of Platelets PHASE2COMPLETED
Ambroxol as a Treatment for Parkinson's Disease Dementia PHASE2UNKNOWN
Tadalafil for Pulmonary Hypertension Due to Chronic Lung Disease PHASE2COMPLETED
Effect of Gemfibrozil on Serum Glycosylphosphatidylinositol (GPI) Phospholipase D and Triglycerides PHASE1COMPLETED
Study of the Prevalence of Acid Sphingomyelinase Deficiency/Niemann Pick AB and B Disease in Patients With Diffuse Interstitial Lung Disease nanNOT_YET_RECRUITING
National Multicentre Study of the Natural History of Acid Sphingo-myelinase Deficiency in Adults and Children nanNOT_YET_RECRUITING
Screening for Gaucher Disease and Acid Sphingomyelinase Deficiency nanNOT_YET_RECRUITING
High-Density Lipoprotein (HDL) Treatment Study nanCOMPLETED
Biomarkers Of Lung InVolvement In ASMD nanUNKNOWN
Studying Lipids as Potential Biomarkers in Patients With Fabry Disease nanCOMPLETED
Evaluation of Plasma Sphingosine-1-Phosphate as A Diagnostic and Prognostic Biomarkers of Community-Acquired Pneumonia nanUNKNOWN
Diagnostic Creteria of Acid Sphingomyelinase Deficiency (ASMD) nanACTIVE_NOT_RECRUITING
Biomarker for Farber Disease (BioFarber) nanWITHDRAWN
Plasma Dihydroceramides Are Associated With Hepatic Steatosis in Type 1 and Type 2 Diabetes nanCOMPLETED
Skeletal Muscle Diacylglycerol and Sphingolipids - Impact of Localization and Species on Insulin Resistance in Humans nanCOMPLETED
A Real-world Long-term Safety and Immunogenicity Study of Olipudase Alfa Therapy in Pediatric Patients Less Than 2 Years of Age With Acid Sphingomyelinase Deficiency (ASMD) nanRECRUITING
Registry Gangliosidoses nanUNKNOWN
Compassionate Use Program for Olipudase Alfa Enzyme Replacement Therapy for Patients With Chronic Acid Sphingomyelinase Deficiency (ASMD) nanAPPROVED_FOR_MARKETING
A Prospective and Retrospective Cohort Study in Patients With Chronic Forms of Acid Sphingomyelinase Deficiency (ASMD) nanCOMPLETED
The ASTERS Study: Assessing the Role of Sphingolipids in AcuTE Respiratory Distress Syndrome (ARDS) nanCOMPLETED
Genetic Studies of Lysosomal Storage Disorders nanENROLLING_BY_INVITATION
Natural History of Glycosphingolipid Storage Disorders and Glycoprotein Disorders nanRECRUITING
Molecular Markers of Human Sperm Function nanWITHDRAWN
Precision Medicine for Sng/Pain Control nanCOMPLETED
Effect of Plasma Ceramides on Peripheral Vascular Function nanCOMPLETED
Biomarker for Metachromatic Leukodystrophy (BioMeta) Disease nanWITHDRAWN
Composition & Function of Sarcoplasmic Reticulum in Persons With the Metabolic Syndrome nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a SMPD4 binder may also engage these)

ProteinNameSimilarity
Q6ZPR5 1.000 Q6ZPR5 →
Q5XHG1 1.000 Q5XHG1 →
Q6PFJ7 0.993 Q6PFJ7 →
B1AUR6 0.992 B1AUR6 →
Q17QK1 0.992 Q17QK1 →
E1BGH8 0.991 E1BGH8 →
E1C2Z0 0.991 E1C2Z0 →
Q9VB98 0.991 Q9VB98 →
Q80UK8 0.990 Q80UK8 →
B5E0H4 0.990 B5E0H4 →
Q9Y3R5 0.990 Q9Y3R5 →
Q5JWR5 0.989 Q5JWR5 →
B3DIY3 0.989 B3DIY3 →
A1L1K1 0.989 A1L1K1 →
P42173 0.989 P42173 →
Q6TNU3 0.989 Q6TNU3 →
Q9P2D8 0.989 Q9P2D8 →
Q4V9P9 0.989 Q4V9P9 →
Q8WUM0 0.989 Q8WUM0 →
E9Q555 0.989 E9Q555 →
Q96N11 0.988 Q96N11 →
F6WXT2 0.988 F6WXT2 →
Q5ZLS8 0.988 Q5ZLS8 →
Q9VPH0 0.988 Q9VPH0 →
Q2NKQ1 0.988 Q2NKQ1 →
A1ZAV1 0.988 A1ZAV1 →
Q6INI0 0.988 Q6INI0 →
Q96C34 0.988 Q96C34 →
F4K4J0 0.988 F4K4J0 →
Q3UGY8 0.988 Q3UGY8 →