SPATS2L — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

	Compound	Confidence	Supporting neighbours

Clinical trials — most relevant to SPATS2L by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effects of Botulinum Toxin Injections in Patients With Hereditary Spastic Paraplegia	PHASE2/PHASE3	COMPLETED
Impact of tdrd9 Gene Mutations in the Therapeutic Response to L-carnitine in Oligoasthenozoospermic Men	PHASE3	ACTIVE_NOT_RECRUITING
Treatment With HMG-COA Reductase Inhibitor of Growth and Bone Abnormalities in Children With Noonan Syndrome	PHASE3	COMPLETED
Safety and Efficacy of AAV9/AP4B1 (BFB-101) For Patients With AP4B1-related Hereditary Spastic Paraplegia Type 47 (SPG47)	PHASE1/PHASE2	NOT_YET_RECRUITING
Cognitive Disorders in Hereditary Spastic Paraplegia Type 4	nan	UNKNOWN
SPATAX: Clinical and Genetic Analysis of Cerebellar Ataxias and Spastic Paraplegias	nan	COMPLETED
Phenotypes, Biomarkers and Pathophysiology in Spastic Ataxias	nan	UNKNOWN
Consequences of Mutations in the SPG7 Gene at the Heterozygous State	nan	COMPLETED
Spastic Paraplegia - Centers of Excellence Research Network	nan	RECRUITING
Evaluation of an Intensive Training Program for Patients with Hereditary Spastic Paraparesis SPG4/Spast	nan	RECRUITING
Efficacy of Pain Neuroscience Education and Physiotherapy in Patients Diagnosed with Spondyloarthritis	nan	COMPLETED
Natural History and Development of Spondyloarthritis	nan	RECRUITING
Hereditary Spastic Paraplegia Genomic Sequencing Initiative (HSPseq)	nan	RECRUITING
Registry and Natural History Study for Early Onset Hereditary Spastic Paraplegia	nan	RECRUITING
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA	nan	RECRUITING
National Psoriasis Foundation - Dendritic Cell-Specific Transmembrane Protein (DC-Stamp) Biomarker Study	nan	COMPLETED
Classification, Functional Stratification and Biomarkers in Ciliopathy (CILLICORIRCM)	nan	COMPLETED
Identification of a New Gene Involved in Hereditary Lipodystrophy	nan	COMPLETED
New Genes in the Carcinogenesis of Colorectal Cancer	nan	UNKNOWN
Muscle Tissue Bank for Muscular Dystrophy	nan	COMPLETED
Ohio Colorectal Cancer Prevention Initiative	nan	COMPLETED
Studying Cognition in SPG4	nan	COMPLETED
Imaging Biomarkers in Crohn's Associated Spondyloarthritis	nan	COMPLETED
Identifying Genes and Mutations Underlying Retinitis Pigmentosa and Allied Diseases	nan	UNKNOWN
Implementation of Molecular Diagnostic Pathways	nan	UNKNOWN
CIQTP Prolongation : Role and Mechanism in Sudden Cardiac Death	nan	COMPLETED
Molecular Genetic Epidemiology of Endocardial Cushion Defects - SCOR in Pediatric Cardiovascular Disease	nan	COMPLETED
Cutaneous Mastocytosis in Children: Analysis of Somatic and Germline Mutations	nan	COMPLETED
Genetic Characterization of Parkinson's Disease	nan	COMPLETED
Surfactant Derived Protocol in Heart Failure	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a SPATS2L binder may also engage these)

Protein	Name	Similarity
Q5U2T3	—	1.000	Q5U2T3 →
Q91WJ7	—	1.000	Q91WJ7 →
Q86XZ4	—	0.994	Q86XZ4 →
Q8K1N4	—	0.987	Q8K1N4 →
Q9UBW5	—	0.986	Q9UBW5 →
Q07E15	—	0.985	Q07E15 →
Q92833	—	0.984	Q92833 →
Q09YI1	—	0.984	Q09YI1 →
D3ZUI5	—	0.982	D3ZUI5 →
Q5RHD1	—	0.982	Q5RHD1 →
Q2IBB2	—	0.982	Q2IBB2 →
Q4V7W5	—	0.981	Q4V7W5 →
B2GUN4	—	0.981	B2GUN4 →
Q2QLA2	—	0.980	Q2QLA2 →
O54828	—	0.980	O54828 →
Q4KKX4	—	0.980	Q4KKX4 →
Q96T21	—	0.980	Q96T21 →
Q32S26	—	0.980	Q32S26 →
Q99LJ0	—	0.979	Q99LJ0 →
Q62925	—	0.979	Q62925 →
Q9JKB5	—	0.979	Q9JKB5 →
Q09YG9	—	0.979	Q09YG9 →
O35589	—	0.979	O35589 →
Q62415	—	0.979	Q62415 →
Q8K3I4	—	0.979	Q8K3I4 →
A5PLL1	—	0.978	A5PLL1 →
Q5RIX9	—	0.978	Q5RIX9 →
Q6Y685	—	0.978	Q6Y685 →
Q9Y4F3	—	0.978	Q9Y4F3 →
Q8CG79	—	0.978	Q8CG79 →