SPCS2

Signal peptidase complex subunit 2 · Q15005 · SPCS2 on Sugi Atlas →

0 patent compounds predicted against SPCS2, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours

Clinical trials — most relevant to SPCS2 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
D-Cycloserine for Serine Palmitoyltransferase Inhibition PHASE4COMPLETED
Pharmacogenomic Evaluation of Antihypertensive Responses PHASE4COMPLETED
Effects of Botulinum Toxin Injections in Patients With Hereditary Spastic Paraplegia PHASE2/PHASE3COMPLETED
Assessment the Activity Value of Isotretinoin (13- Cis-Retinoic Acid ) in the Treatment of COVID-19 ( Isotretinoin in Treatment of COVID-19) (Randomized) PHASE3UNKNOWN
Neurobiology of a Mutation in Glycine Metabolism in Psychotic Disorders PHASE2COMPLETED
Melpida: Recombinant Adeno-associated Virus (serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt) PHASE1/PHASE2RECRUITING
A Study of Hydroxychloroquine in Combination With Gemcitabine/Abraxane in Pancreatic Cancer PHASE1/PHASE2COMPLETED
Combination Therapy With Isotretinoin and Tamoxifen Expected to Provide Complete Protection Against Severe Acute Respiratory Syndrome Coronavirus PHASE2UNKNOWN
PCSK9 Inhibitor Treatment for Patients With SPG5 PHASE1/PHASE2UNKNOWN
Hydroxychloroquin (HCQ) in chILD of Genetic Defect nanCOMPLETED
Surfactant Derived Protocol in Heart Failure nanCOMPLETED
Genetic Mechanisms of Chronic Obstructive Pulmonary Disease (COPD) nanCOMPLETED
Genetic Regulation of Surfactant Deficiency nanCOMPLETED
Role of SF3B1 Mutation in Assessment of Acute and Chronic Lymphatic Leukemia nanNOT_YET_RECRUITING
Genetic Characterization of Parkinson's Disease nanCOMPLETED
Consequences of Mutations in the SPG7 Gene at the Heterozygous State nanCOMPLETED
Pathogenesis of Primary Ciliary Dyskinesia (PCD) Lung Disease nanRECRUITING
Circadian Rhythms and Sleep in Familial DSPS and ASPS nanCOMPLETED
Genetic Variants and Regulation of Specialized Pro-resolving Mediator nanRECRUITING
Identification of Biomarkers Associated With Human Hepatocellular Carcinoma by SELDI nanUNKNOWN
Natural History Study of Smith-Magenis Syndrome nanACTIVE_NOT_RECRUITING
Genetic Analysis of Gray Platelet Syndrome nanCOMPLETED
Genetic Analysis of Hereditary Disorders of Hearing and Balance nanCOMPLETED
PCD New Gene Discovery nanCOMPLETED
Aberrant Splicings Due to Microsatellite Instability in Colorectal Cancer : Physiopathological and Clinical Impact nanUNKNOWN
SNAP: Measurement of the Subjective Perception of the Symptom in Hereditary Spastic Paraparesis (HSP) nanCOMPLETED
Identifying Genes and Mutations Underlying Retinitis Pigmentosa and Allied Diseases nanUNKNOWN
Diagnosis of Primary Ciliary Dyskinesia nanCOMPLETED
JAK-STAT Signalling Pathway in Familial Myeloproliferative Disorders nanCOMPLETED
Investigation of Copy Number Variations and Genetic Variants in POI nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a SPCS2 binder may also engage these)

ProteinNameSimilarity
Q4R512 1.000 Q4R512 →
Q9CYN2 1.000 Q9CYN2 →
Q5RAY6 0.999 Q5RAY6 →
Q28250 0.995 Q28250 →
Q5M8Y1 0.994 Q5M8Y1 →
Q5BJI9 0.986 Q5BJI9 →
Q28C34 0.968 Q28C34 →
Q8IWV8 0.968 Q8IWV8 →
Q5RF53 0.967 Q5RF53 →
Q6P4P2 0.966 Q6P4P2 →
Q8N6S4 0.966 Q8N6S4 →
O00507 0.966 O00507 →
F1QR43 0.965 F1QR43 →
Q5ZMW3 0.965 Q5ZMW3 →
Q6TEP1 0.965 Q6TEP1 →
Q5F3F5 0.965 Q5F3F5 →
O35841 0.965 O35841 →
A4GWN3 0.965 A4GWN3 →
Q8BWQ6 0.964 Q8BWQ6 →
Q8C561 0.963 Q8C561 →
Q5R644 0.963 Q5R644 →
Q5ZKG8 0.963 Q5ZKG8 →
Q68DH5 0.963 Q68DH5 →
Q5RAQ5 0.963 Q5RAQ5 →
Q8C735 0.962 Q8C735 →
Q56A27 0.962 Q56A27 →
Q4R8N2 0.962 Q4R8N2 →
Q3SYY9 0.962 Q3SYY9 →
Q8BM39 0.961 Q8BM39 →
Q5XIK2 0.961 Q5XIK2 →