Sugi Predict

Sugi Predict / Targets / SPG11

SPG11

Spatacsin · Q96JI7 · SPG11 on Sugi Atlas →

0 patent compounds predicted against SPG11, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours

Clinical trials — most relevant to SPG11 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Effects of Botulinum Toxin Injections in Patients With Hereditary Spastic Paraplegia PHASE2/PHASE3COMPLETED
Impact of tdrd9 Gene Mutations in the Therapeutic Response to L-carnitine in Oligoasthenozoospermic Men PHASE3ACTIVE_NOT_RECRUITING
Melpida: Recombinant Adeno-associated Virus (serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt) PHASE1/PHASE2RECRUITING
Hereditary Sensory Neuropathy Serine Trial PHASE2UNKNOWN
Therapeutic Metabolic Intervention in Patients With Spastic Paraplegia SPG5 PHASE2COMPLETED
Calcium Folinate Treatment of Spastic Paraplegia 56 EARLY_PHASE1RECRUITING
Consequences of Mutations in the SPG7 Gene at the Heterozygous State nanCOMPLETED
New Genes in the Carcinogenesis of Colorectal Cancer nanUNKNOWN
Hydroxychloroquin (HCQ) in chILD of Genetic Defect nanCOMPLETED
SPATAX: Clinical and Genetic Analysis of Cerebellar Ataxias and Spastic Paraplegias nanCOMPLETED
Evaluation of an Intensive Training Program for Patients with Hereditary Spastic Paraparesis SPG4/Spast nanRECRUITING
Surfactant Derived Protocol in Heart Failure nanCOMPLETED
Spastic Paraplegia - Centers of Excellence Research Network nanRECRUITING
3D-Microscopic Muscle Architecture in Cerebral Palsy nanRECRUITING
Phenotypes, Biomarkers and Pathophysiology in Spastic Ataxias nanUNKNOWN
Studying Cognition in SPG4 nanCOMPLETED
Hereditary Spastic Paraplegia Genomic Sequencing Initiative (HSPseq) nanRECRUITING
Molecular Genetic Epidemiology of Endocardial Cushion Defects - SCOR in Pediatric Cardiovascular Disease nanCOMPLETED
Implementation of Molecular Diagnostic Pathways nanUNKNOWN
Trehalose Administration in Subjects With Spastic Paraplegia 11 (3AL-SPG11) nanCOMPLETED
Role of Sorcin and Annexin A3 in Breast Cancer Patients nanUNKNOWN
CP-EDIT: Cerebral Palsy - Early Diagnosis and Intervention Trial nanRECRUITING
Natural History and Development of Spondyloarthritis nanRECRUITING
PCD New Gene Discovery nanCOMPLETED
Genetic Regulation of Surfactant Deficiency nanCOMPLETED
A Novel Mutation of the Spectrin Gene nanCOMPLETED
Registry and Natural History Study for Early Onset Hereditary Spastic Paraplegia nanRECRUITING
Genetic Factors That Influence Chronic Obstructive Pulmonary Disease in Hispanics nanCOMPLETED
Diagnosis of Primary Ciliary Dyskinesia nanCOMPLETED
Phenotypes, Biomarkers and Pathophysiology in Hereditary Spastic Paraplegias and Related Disorders nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a SPG11 binder may also engage these)

ProteinNameSimilarity
GSAP Gamma-secretase-activating protein 0.996 landscape →
Q5H9S7 — 0.995 Q5H9S7 →
O35870 — 0.993 O35870 →
Q90WN7 — 0.993 Q90WN7 →
Q75QN2 — 0.992 Q75QN2 →
Q3UHA3 — 0.992 Q3UHA3 →
P97313 — 0.992 P97313 →
Q9DAU9 — 0.992 Q9DAU9 →
Q3UHQ6 — 0.992 Q3UHQ6 →
GTF3C4 General transcription factor 3C polypeptide 4 0.991 landscape →
Q9FFF9 — 0.991 Q9FFF9 →
Q13129 — 0.991 Q13129 →
Q9Z2U2 — 0.991 Q9Z2U2 →
Q08D12 — 0.991 Q08D12 →
RNF213 E3 ubiquitin-protein ligase RNF213 0.991 landscape →
PIK3C2A Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha 0.990 landscape →
Q99698 — 0.990 Q99698 →
A6QR20 — 0.990 A6QR20 →
Q8CE72 — 0.990 Q8CE72 →
Q80TB7 — 0.990 Q80TB7 →
Q91VB4 — 0.989 Q91VB4 →
TARBP1 tRNA (guanosine(18)-2'-O)-methyltransferase TARBP1 0.989 landscape →
Q3UPC7 — 0.989 Q3UPC7 →
Q3TCV3 — 0.989 Q3TCV3 →
Q8H0T4 — 0.989 Q8H0T4 →
Q8BV79 — 0.989 Q8BV79 →
Q9SUG7 — 0.989 Q9SUG7 →
Q5XI94 — 0.988 Q5XI94 →
Q9ESK9 — 0.988 Q9ESK9 →
Q96NH3 — 0.988 Q96NH3 →