SPTLC2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL6982993	0.77	9/20
Hydrochloric Acid (SCHEMBL6975644)	0.75	9/20
SCHEMBL6978484	0.66	9/20
SCHEMBL6970294	0.66	9/20
SCHEMBL6979035	0.64	9/20
SCHEMBL6974848	0.53	9/20
SCHEMBL11842220	0.67	8/20
SCHEMBL11842232	0.67	8/20
SCHEMBL11842242	0.67	8/20
SCHEMBL485025	0.40	8/20
SCHEMBL14257956	0.48	6/20
SCHEMBL13801299	0.46	6/20
SCHEMBL13801631	0.46	6/20
SCHEMBL13814660	0.46	6/20
SCHEMBL4148999	0.43	6/20
SCHEMBL4149002	0.43	6/20
SCHEMBL4149557	0.43	6/20
SCHEMBL4151130	0.43	6/20
SCHEMBL4151135	0.43	6/20
SCHEMBL4153226	0.43	6/20

Clinical trials — most relevant to SPTLC2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Cystagon to Treat Infantile Neuronal Ceroid Lipofuscinosis	PHASE4	COMPLETED
Hereditary Sensory Neuropathy Serine Trial	PHASE2	UNKNOWN
Anti-inflammatory Pulmonal Therapy of Cystic Fibrosis (CF) Patients With Amitriptyline and Placebo	PHASE2	UNKNOWN
Anti-Inflammatory Pulmonal Therapy of CF-Patients With Amitriptyline and Placebo	PHASE2	COMPLETED
Effect of Gemfibrozil on Serum Glycosylphosphatidylinositol (GPI) Phospholipase D and Triglycerides	PHASE1	COMPLETED
Choline Effects - Pre-symptomatic AD	PHASE1	COMPLETED
Sphingo-lipotoxicity and Trans-differentiation of Adipose Tissue in Obesity (SFINGOTRANS)	nan	COMPLETED
Skeletal Muscle Diacylglycerol and Sphingolipids - Impact of Localization and Species on Insulin Resistance in Humans	nan	COMPLETED
Lipidomic and Multi-Omics Profiling of Fatty Liver Disease in People With and Without HIV	nan	NOT_YET_RECRUITING
Development of Biomarker for Development of Non-Alcoholic Steatohepatitis (NASH) in Children	nan	WITHDRAWN
Duality of Lipids: the Athlete's Paradox	nan	COMPLETED
Genetic and Environmental Determinants of Triglycerides (GOLDN)	nan	COMPLETED
Evaluating the Association Between Sphingolipid Metabolites and Post-hepatectomy Liver Failure	nan	COMPLETED
Ceramide Level as Apredictor of Outcomes in Patients of Anterior Myocardial Infarction Undergoing Primary Coronary Intervention	nan	UNKNOWN
The ASTERS Study: Assessing the Role of Sphingolipids in AcuTE Respiratory Distress Syndrome (ARDS)	nan	COMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
Plasma Dihydroceramides Are Associated With Hepatic Steatosis in Type 1 and Type 2 Diabetes	nan	COMPLETED
Targeting zDHHC Enzymes to Counteract Alzheimer's Disease	nan	NOT_YET_RECRUITING
Gene Expression in Obesity and Insulin Resistance	nan	COMPLETED
Identification of Women With Severe Insulin Resistant Syndromes of Genetic Origin Among Patients With Classic Polycystic Ovary Syndrome (PCOS)	nan	NOT_YET_RECRUITING
Epigenomic and Metabolomic Signatures of APOA2 Gene by Saturated Fat Interaction	nan	COMPLETED
Evaluation of Plasma Sphingosine-1-Phosphate as A Diagnostic and Prognostic Biomarkers of Community-Acquired Pneumonia	nan	UNKNOWN
Biomarker for Farber Disease (BioFarber)	nan	WITHDRAWN
Effect of Omega-3 Fatty Acids Supplementation on Hypertriglyceridemia in Pediatric Patients With Obesity.	nan	COMPLETED
Vulvodynia: Identification of Potential Relevant Biomarkers	nan	COMPLETED
Studying Lipids as Potential Biomarkers in Patients With Fabry Disease	nan	COMPLETED
Precision Medicine for Sng/Pain Control	nan	COMPLETED
Enpowering Progression Risk of Cerebral Amyloid Angiopathy	nan	COMPLETED
In Vivo Metabolism of apoB-containing Lipoproteins in ANGPTL3 Deficient Subjects	nan	UNKNOWN
Gene Expression of Endocannabinoid System in Episodic and Chronic Migraine Patients	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a SPTLC2 binder may also engage these)

Protein	Name	Similarity
P97363	—	1.000	P97363 →
O54694	—	1.000	O54694 →
Q3B7D2	—	0.998	Q3B7D2 →
SPTLC3	Serine palmitoyltransferase 3	0.998	landscape →
Q20375	—	0.991	Q20375 →
Q8RYL1	—	0.990	Q8RYL1 →
Q9M304	—	0.990	Q9M304 →
Q8RYL0	—	0.988	Q8RYL0 →
Q2R3K3	—	0.987	Q2R3K3 →
Q9XVI6	—	0.987	Q9XVI6 →
Q9LSZ9	—	0.986	Q9LSZ9 →
Q5JK39	—	0.985	Q5JK39 →
Q54EX5	—	0.983	Q54EX5 →
Q8BG54	—	0.982	Q8BG54 →
Q8R0X7	—	0.980	Q8R0X7 →
P40970	—	0.980	P40970 →
P48241	—	0.980	P48241 →
Q9V7Y2	—	0.980	Q9V7Y2 →
Q52RG7	—	0.979	Q52RG7 →
SGPL1	Sphingosine-1-phosphate lyase 1	0.977	landscape →
Q8CHN6	—	0.976	Q8CHN6 →
Q75DX7	—	0.976	Q75DX7 →
Q16P90	—	0.975	Q16P90 →
Q6K8E7	—	0.975	Q6K8E7 →
Q05567	—	0.974	Q05567 →
Q94IB8	—	0.974	Q94IB8 →
Q10P01	—	0.974	Q10P01 →
Q5R4G0	—	0.974	Q5R4G0 →
Q9C509	—	0.973	Q9C509 →
P91079	—	0.973	P91079 →