STXBP1

Syntaxin-binding protein 1 · P61764 · STXBP1 on Sugi Atlas →

0 patent compounds predicted against STXBP1, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours

Clinical trials — most relevant to STXBP1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Safety and Efficacy of AAV9/AP4B1 (BFB-101) For Patients With AP4B1-related Hereditary Spastic Paraplegia Type 47 (SPG47) PHASE1/PHASE2NOT_YET_RECRUITING
PET Brain Imaging in Multiple Sclerosis, Alzheimer's Disease, and Other Neurological and Neuropsychiatric Diseases PHASE1/PHASE2RECRUITING
Melpida: Recombinant Adeno-associated Virus (serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt) PHASE1/PHASE2RECRUITING
Sirolimus Treatment in Patients With Autosomal Dominant Polycystic Kidney Disease: Renal Efficacy and Safety PHASE2COMPLETED
Nilotinib in Huntington's Disease PHASE1UNKNOWN
Phenylbutyrate for Monogenetic Developmental and Epileptic Encephalopathy EARLY_PHASE1ACTIVE_NOT_RECRUITING
MEG Study of Acute STX209 Effects in ASD EARLY_PHASE1COMPLETED
Natural History Study in Pediatric Patients with STXBP1 Encephalopathy with Epilepsy nanWITHDRAWN
STXBP1 and SYNGAP1 Related Disorders Natural History Study nanRECRUITING
A Multicentric European Study to Promote Clinical Trial Readiness for STXBP1-related Disorders nanRECRUITING
Phenotyping and Identification of Biological Markers in STXBP1 Encephalopathy nanNOT_YET_RECRUITING
Gait in Rare Diseases nanCOMPLETED
Genetic Characterization of Parkinson's Disease nanCOMPLETED
Gene-STEPS: Shortening Time of Evaluation in Paediatric Epilepsy Services nanUNKNOWN
Autophagy in Systemic Lupus Erythematosus nanUNKNOWN
Susceptibility Genes in Autism Spectrum Disorders nanCOMPLETED
Toward Molecular Profiling of Parkinson's Disease in Easily Accessible Biological Matrices nanACTIVE_NOT_RECRUITING
Transcriptomic Profile of Patients Treated With Different Modalities of Spinal Cord Stimulation nanUNKNOWN
Stem Cell Models of Best Disease and Other Retinal Degenerative Diseases. nanCOMPLETED
Assessing the Polygenic Burden of Rare Disruptive Mutations in Parkinson's Disease nanUNKNOWN
Regulation of Lymphocyte Anti-tumor Response in Metastatic Patients Treated With the mTOR Inhibitor Everolimus nanCOMPLETED
The Influence of Genetic Variations in ELAPOR1 or ELAPOR2 on Insulin Secretion and Glucose Regulation in Humans nanUNKNOWN
Study of the Genetic Factors Involved in Autism and Related Disorders nanRECRUITING
Genetic Variants Associated With Adolescent Suicide Attempts nanCOMPLETED
Genes, Proteins, and Metabolites in Drug-resistant Epilepsy (DRE) Patients nanNOT_YET_RECRUITING
Early Recognition and Intervention in Siblings at High-risk for Neurodevelopmental Disorder nanUNKNOWN
Characterization of New Candidate Genes in Cases of Human Inherited Thrombocytopenia (CATCH) nanCOMPLETED
Clinical and Genetic Study of Autism Spectrum Disorder nanCOMPLETED
Investigating Phenotypic, Epigenetic, and NeuroGenetic Traits in Rare and Ultra-rare Neurodevelopmental Disorders (Project PENGUIN) nanRECRUITING
Autophagy Bladder Cancer nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a STXBP1 binder may also engage these)

ProteinNameSimilarity
P61763 1.000 P61763 →
Q5R6D2 1.000 Q5R6D2 →
P61765 1.000 P61765 →
O08599 1.000 O08599 →
Q6R748 1.000 Q6R748 →
Q07327 1.000 Q07327 →
O00186 1.000 O00186 →
P34815 1.000 P34815 →
Q54QC8 1.000 Q54QC8 →
Q28288 1.000 Q28288 →
Q60770 1.000 Q60770 →
Q15833 1.000 Q15833 →
Q62753 0.998 Q62753 →
O94590 0.997 O94590 →
Q9SZ77 0.996 Q9SZ77 →
Q7XWP3 0.996 Q7XWP3 →
O18637 0.996 O18637 →
Q9C5P7 0.996 Q9C5P7 →
Q64324 0.996 Q64324 →
Q9C5X3 0.994 Q9C5X3 →
Q5VNU3 0.994 Q5VNU3 →
Q24179 0.994 Q24179 →
Q9P7V6 0.993 Q9P7V6 →
O74534 0.993 O74534 →
P34260 0.992 P34260 →
B4NBB0 0.991 B4NBB0 →
Q8SS97 0.991 Q8SS97 →
Q94KJ7 0.991 Q94KJ7 →
Q18891 0.991 Q18891 →
B0XDC4 0.991 B0XDC4 →