TARS2

Threonine--tRNA ligase, mitochondrial · Q9BW92 · TARS2 on Sugi Atlas →

0 patent compounds predicted against TARS2, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours

Clinical trials — most relevant to TARS2 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
A Study of the Efficacy and Safety of MT1621 in Thymidine Kinase 2 (TK2) Deficiency (Treatment naïve) PHASE3WITHDRAWN
Treatment of TK2 Deficiency With Thymidine and Deoxycytidine PHASE1/PHASE2ACTIVE_NOT_RECRUITING
Doxecitin and Doxribthymine in Adult Subjects With Thymidine Kinase 2 (TK2) Deficiency PHASE2RECRUITING
ONC201 in Recurrent/Refractory Metastatic Breast Cancer and Advanced Endometrial Carcinoma PHASE2COMPLETED
Dynamics of Muscle Mitochondria in Type 2 Diabetes (DYNAMMO T2D) EARLY_PHASE1COMPLETED
Mitigating Mitochondrial RNA Release During Aging to Control Inflammation and Senescence nanNOT_YET_RECRUITING
Measuring Protein Turnover in Humans Across the Lifespan by Metabolic Labeling With Deuterium Oxide nanRECRUITING
Mitochondrial Dysfunctions Driving Insulin Resistance nanCOMPLETED
Tissue Sample Study for Mitochondrial Disorders nanENROLLING_BY_INVITATION
Exercise-mediated Rescue of Mitochondrial Dysfunctions Driving Insulin Resistance nanCOMPLETED
Skeletal Muscle Regeneration in Survivors of Critical Illness: How to Prevent Satellite Cell Failure? nanRECRUITING
Nicotinamide Riboside and Mitochondrial Biogenesis nanCOMPLETED
Mitochondrial Dysfunction in Phelan-McDermid Syndrome nanCOMPLETED
GDF-15 as a Biomarker for Mitochondrial Disease nanCOMPLETED
Dynamics of Muscle Mitochondria in Type 2 Diabetes Exercise nanCOMPLETED
Nutritional Assessment in Mitochondrial Cytopathy nanCOMPLETED
MITOMICS : a Multi-OMICS Approach for the Diagnosis of Mitochondrial Diseases nanRECRUITING
Clinical Study of Hydroxytyrosol (HT) in Mitochondrial Diseases nanCOMPLETED
The Natural History of Mitochondrial Diseases nanRECRUITING
The Genetics of Diabetes in Southern California Chinese Americans nanWITHDRAWN
Identification of New Candidate Genes in Patients With Mitochondrial Disease by High Resolution Chromosome Analysis on DNA Chip nanCOMPLETED
Biological Aging Hallmarks-Guided Integrative TCM and Conventional Medicine in Post-Treatment Unexplained Female Infertility nanRECRUITING
Mitochondrial Dysfunction in Diabetes nanCOMPLETED
Drug Repurposing for Mitochondrial Disorders Using iPSCs Derived Neural Cells nanRECRUITING
Natural History Study of FDXR Mutation-related Mitochondriopathy nanCOMPLETED
DNA QUANTIFICATION TECHNIQUE AS A INTERPRETATION TOOL IN MITOCHONDRIAL DISEASES nanCOMPLETED
MERC Proteins in Saliva and GCF in Periodontal Disease (ELISA Study) nanCOMPLETED
Relationship Between Mitochondrial Dysfunction and Fatique in Cancer Patients Following External Beam Radiation Therapy nanCOMPLETED
Mitochondrial Disease-associated ImmunoDeficiencies nanRECRUITING
Effect of Exercise Training on Protein Expression in Skeletal Muscle Tissue After Exercise in Peripheral Arterial Disease nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a TARS2 binder may also engage these)

ProteinNameSimilarity
Q3UQ84 1.000 Q3UQ84 →
Q68FW7 1.000 Q68FW7 →
Q5JTZ9 0.999 Q5JTZ9 →
A6QNM8 0.991 A6QNM8 →
Q2V057 0.988 Q2V057 →
Q8VCZ9 0.988 Q8VCZ9 →
Q86U10 0.988 Q86U10 →
Q8BLY2 0.987 Q8BLY2 →
D3ZX08 0.986 D3ZX08 →
Q9JJL8 0.986 Q9JJL8 →
Q14CH7 0.985 Q14CH7 →
Q8VDP3 0.985 Q8VDP3 →
Q5RCH4 0.984 Q5RCH4 →
Q6P3H4 0.984 Q6P3H4 →
A0A1U8CC89 0.984 A0A1U8CC89 →
Q6MG21 0.983 Q6MG21 →
O43542 0.983 O43542 →
A5D7V9 0.982 A5D7V9 →
O55171 0.982 O55171 →
D3ZBP4 0.982 D3ZBP4 →
O75879 0.982 O75879 →
Q91XE4 0.982 Q91XE4 →
Q8R123 0.982 Q8R123 →
Q08DH8 0.981 Q08DH8 →
Q5ST30 0.980 Q5ST30 →
Q99N42 0.980 Q99N42 →
Q8N8Q3 0.980 Q8N8Q3 →
Q767M3 0.980 Q767M3 →
Q8WZ82 0.980 Q8WZ82 →
Q99KK9 0.980 Q99KK9 →